Fluorescence Probe for Detecting CCG Trinucleotide Repeat DNA Expansion and Slip-Out

Trinucleotide repeat expansion in genomic DNA causes severe neurodegenerative diseases. Fluorescence probes that bind to trinucleotide repeats have potential as diagnostic tools of trinucleotide repeat disorders. Here, we report a novel tricyclic ligand that binds to CCG trinucleotide repeat DNA. Th...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2016-09, Vol.17 (18), p.1685-1688
Hauptverfasser:	Shibata, Tomonori, Nakatani, Kazuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	(CCG)n repeat Deoxyribonucleic acid DNA DNA - analysis DNA - chemistry DNA - genetics Expansion fluorescence probes Fluorescent Dyes - analysis Fluorescent Dyes - chemistry hydrogen bonds Ligands molecular recognition Molecular Structure slip-out DNA Spectrometry, Fluorescence Trinucleotide Repeat Expansion - genetics
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