Hepatic Elovl6 gene expression is regulated by the synergistic action of ChREBP and SREBP-1c

Elongation of very long chain fatty acids protein 6 (ELOVL6), a rate-limiting enzyme for the elongation of saturated and monounsaturated fatty acids with 12, 14, and 16 carbons, plays a key role in energy metabolism and insulin sensitivity. Hepatic Elovl6 expression is upregulated in the fasting-ref...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-09, Vol.478 (3), p.1060-1066
Hauptverfasser:	Bae, Jin-Sik, Oh, Ah-Reum, Lee, Ho-Jae, Ahn, Yong-ho, Cha, Ji-Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases - genetics Acetyltransferases - metabolism Animals Base Sequence Carbohydrate ChREBP Elovl6 Feeding Behavior Gene Expression Regulation Hep G2 Cells Humans Liver - metabolism Mice, Inbred C57BL Mice, Knockout Mutation - genetics Nuclear Proteins - metabolism Protein Binding - genetics Response Elements - genetics RNA, Messenger - genetics RNA, Messenger - metabolism SREBP-1c Sterol Regulatory Element Binding Protein 1 - metabolism Transcription Factors - metabolism Transcriptional regulation
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