Effect of Arthroscopic Lavage on Systemic and Synovial Fluid Serum Amyloid A in Healthy Horses

OBJECTIVE: To evaluate the effect of arthroscopic lavage on systemic serum amyloid A (SAA) and SAA, total protein, nucleated cell count, and percentage of neutrophils in synovial fluid in healthy horses. STUDY DESIGN: Prospective experimental study. ANIMALS: Healthy adult horses (n = 6). METHODS: Mi...

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Veröffentlicht in:Veterinary surgery 2016-02, Vol.45 (2), p.223-230
Hauptverfasser: Sanchez-Teran, Andres F., Bracamonte, José L., Hendrick, Steven, Burguess, Hilary J., Duke-Novakovski, Tanya, Schott, Monica, Hoff, Brent, Rubio-Martínez, Luis M.
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container_end_page 230
container_issue 2
container_start_page 223
container_title Veterinary surgery
container_volume 45
creator Sanchez-Teran, Andres F.
Bracamonte, José L.
Hendrick, Steven
Burguess, Hilary J.
Duke-Novakovski, Tanya
Schott, Monica
Hoff, Brent
Rubio-Martínez, Luis M.
description OBJECTIVE: To evaluate the effect of arthroscopic lavage on systemic serum amyloid A (SAA) and SAA, total protein, nucleated cell count, and percentage of neutrophils in synovial fluid in healthy horses. STUDY DESIGN: Prospective experimental study. ANIMALS: Healthy adult horses (n = 6). METHODS: Middle carpal joints were randomly assigned to 1 of 2 treatments: arthrocentesis (controls) or arthroscopic lavage, with 30 day washout period between treatments. Synovial fluid and blood samples were collected at 0, 24, 48, 72, 96, and 120 hours. Measurements included systemic and synovial fluid SAA, as well as total protein, nucleated cell count, and percentages of neutrophils in synovial fluid. Data were analyzed by median quantile regression and Wilcoxon signed‐rank test and significance level set at P 
doi_str_mv 10.1111/vsu.12439
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STUDY DESIGN: Prospective experimental study. ANIMALS: Healthy adult horses (n = 6). METHODS: Middle carpal joints were randomly assigned to 1 of 2 treatments: arthrocentesis (controls) or arthroscopic lavage, with 30 day washout period between treatments. Synovial fluid and blood samples were collected at 0, 24, 48, 72, 96, and 120 hours. Measurements included systemic and synovial fluid SAA, as well as total protein, nucleated cell count, and percentages of neutrophils in synovial fluid. Data were analyzed by median quantile regression and Wilcoxon signed‐rank test and significance level set at P &lt; .05. RESULTS: Systemic and synovial fluid SAA did not increase from baseline (except systemic SAA at 24 hours for both treatments) and were not significantly different between treatments. Total protein values were significantly increased after arthroscopic lavage (except at 96 hours) but not in controls at all time points. With both treatments, nucleated cell counts significantly increased from baseline values at all time points. Percentages of neutrophils were significantly increased after arthroscopic lavage at all time points, but only at 24 hours in controls. CONCLUSION: Total protein, nucleated cell count, and percentage of neutrophils in synovial fluid were significantly increased after arthroscopic lavage; however, synovial fluid SAA was not affected by this procedure. Further research is warranted to validate synovial fluid SAA as a monitoring tool during treatment of septic arthritis.</description><identifier>ISSN: 0161-3499</identifier><identifier>EISSN: 1532-950X</identifier><identifier>DOI: 10.1111/vsu.12439</identifier><identifier>PMID: 26767549</identifier><language>eng</language><publisher>United States: Blackwell [etc.]</publisher><subject>Animals ; Arthritis ; Arthroscopy ; Female ; Horse Diseases - surgery ; Horse Diseases - therapy ; Horses ; Injections, Intra-Articular - veterinary ; Joint Diseases - veterinary ; Male ; Neutrophils ; Prospective Studies ; Proteins ; Serum Amyloid A Protein - metabolism ; Synovial Fluid - cytology ; Synovial Fluid - metabolism ; Therapeutic Irrigation - veterinary ; Veterinary medicine</subject><ispartof>Veterinary surgery, 2016-02, Vol.45 (2), p.223-230</ispartof><rights>Copyright 2016 by The American College of Veterinary Surgeons</rights><rights>Copyright 2016 by The American College of Veterinary Surgeons.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5189-5a9ad628b74409ba0032382634b352d45d15987cf78fcf7315b8aa0a89efc6393</citedby><cites>FETCH-LOGICAL-c5189-5a9ad628b74409ba0032382634b352d45d15987cf78fcf7315b8aa0a89efc6393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fvsu.12439$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fvsu.12439$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26767549$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sanchez-Teran, Andres F.</creatorcontrib><creatorcontrib>Bracamonte, José L.</creatorcontrib><creatorcontrib>Hendrick, Steven</creatorcontrib><creatorcontrib>Burguess, Hilary J.</creatorcontrib><creatorcontrib>Duke-Novakovski, Tanya</creatorcontrib><creatorcontrib>Schott, Monica</creatorcontrib><creatorcontrib>Hoff, Brent</creatorcontrib><creatorcontrib>Rubio-Martínez, Luis M.</creatorcontrib><title>Effect of Arthroscopic Lavage on Systemic and Synovial Fluid Serum Amyloid A in Healthy Horses</title><title>Veterinary surgery</title><addtitle>Veterinary Surgery</addtitle><description>OBJECTIVE: To evaluate the effect of arthroscopic lavage on systemic serum amyloid A (SAA) and SAA, total protein, nucleated cell count, and percentage of neutrophils in synovial fluid in healthy horses. STUDY DESIGN: Prospective experimental study. ANIMALS: Healthy adult horses (n = 6). METHODS: Middle carpal joints were randomly assigned to 1 of 2 treatments: arthrocentesis (controls) or arthroscopic lavage, with 30 day washout period between treatments. Synovial fluid and blood samples were collected at 0, 24, 48, 72, 96, and 120 hours. Measurements included systemic and synovial fluid SAA, as well as total protein, nucleated cell count, and percentages of neutrophils in synovial fluid. Data were analyzed by median quantile regression and Wilcoxon signed‐rank test and significance level set at P &lt; .05. RESULTS: Systemic and synovial fluid SAA did not increase from baseline (except systemic SAA at 24 hours for both treatments) and were not significantly different between treatments. Total protein values were significantly increased after arthroscopic lavage (except at 96 hours) but not in controls at all time points. With both treatments, nucleated cell counts significantly increased from baseline values at all time points. Percentages of neutrophils were significantly increased after arthroscopic lavage at all time points, but only at 24 hours in controls. CONCLUSION: Total protein, nucleated cell count, and percentage of neutrophils in synovial fluid were significantly increased after arthroscopic lavage; however, synovial fluid SAA was not affected by this procedure. Further research is warranted to validate synovial fluid SAA as a monitoring tool during treatment of septic arthritis.</description><subject>Animals</subject><subject>Arthritis</subject><subject>Arthroscopy</subject><subject>Female</subject><subject>Horse Diseases - surgery</subject><subject>Horse Diseases - therapy</subject><subject>Horses</subject><subject>Injections, Intra-Articular - veterinary</subject><subject>Joint Diseases - veterinary</subject><subject>Male</subject><subject>Neutrophils</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Serum Amyloid A Protein - metabolism</subject><subject>Synovial Fluid - cytology</subject><subject>Synovial Fluid - metabolism</subject><subject>Therapeutic Irrigation - veterinary</subject><subject>Veterinary medicine</subject><issn>0161-3499</issn><issn>1532-950X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1u1DAUhS0EokNhwQuAJTawSOt_x8tR1XaQRrAYpnSF5SROm5LEg51Mm7fnlrRdICEs2VfX-u6RfI4RekvJEYV1vE_jEWWCm2doQSVnmZHk8jlaEKpoxoUxB-hVSjeEECMEf4kOmNJKS2EW6MdpXftywKHGyzhcx5DKsGtKvHZ7d-Vx6PFmSoPv4Mr1FTR92DeuxWft2EDr49jhZTe1Abolbnq88q4drie8CjH59Bq9qF2b_JuHeoi2Z6ffTlbZ-uv555PlOislzU0mnXGVYnmhhSCmcIRwxnOmuCi4ZJWQFZUm12Wt8xoOTmWRO0dcbnxdKm74Ifo46-5i-DX6NNiuSaVvW9f7MCZLc6YNJVrz_6NaMS5yMAvQD3-hN2GMPTzknqLCgL8CqE8zVYJ7Kfra7mLTuThZSux9PhbysX_yAfbdg-JYdL56Ih8DAeB4Bm6b1k__VrIXm-2jZDZPNJDT3dOEiz-t0lxL-_3Lub2UbHVhhLFr4N_PfO2CdVexSXa7YfBVCGxNFOG_ATeYr4c</recordid><startdate>201602</startdate><enddate>201602</enddate><creator>Sanchez-Teran, Andres F.</creator><creator>Bracamonte, José L.</creator><creator>Hendrick, Steven</creator><creator>Burguess, Hilary J.</creator><creator>Duke-Novakovski, Tanya</creator><creator>Schott, Monica</creator><creator>Hoff, Brent</creator><creator>Rubio-Martínez, Luis M.</creator><general>Blackwell [etc.]</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>201602</creationdate><title>Effect of Arthroscopic Lavage on Systemic and Synovial Fluid Serum Amyloid A in Healthy Horses</title><author>Sanchez-Teran, Andres F. ; Bracamonte, José L. ; Hendrick, Steven ; Burguess, Hilary J. ; Duke-Novakovski, Tanya ; Schott, Monica ; Hoff, Brent ; Rubio-Martínez, Luis M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5189-5a9ad628b74409ba0032382634b352d45d15987cf78fcf7315b8aa0a89efc6393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Arthritis</topic><topic>Arthroscopy</topic><topic>Female</topic><topic>Horse Diseases - surgery</topic><topic>Horse Diseases - therapy</topic><topic>Horses</topic><topic>Injections, Intra-Articular - veterinary</topic><topic>Joint Diseases - veterinary</topic><topic>Male</topic><topic>Neutrophils</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Serum Amyloid A Protein - metabolism</topic><topic>Synovial Fluid - cytology</topic><topic>Synovial Fluid - metabolism</topic><topic>Therapeutic Irrigation - veterinary</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sanchez-Teran, Andres F.</creatorcontrib><creatorcontrib>Bracamonte, José L.</creatorcontrib><creatorcontrib>Hendrick, Steven</creatorcontrib><creatorcontrib>Burguess, Hilary J.</creatorcontrib><creatorcontrib>Duke-Novakovski, Tanya</creatorcontrib><creatorcontrib>Schott, Monica</creatorcontrib><creatorcontrib>Hoff, Brent</creatorcontrib><creatorcontrib>Rubio-Martínez, Luis M.</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Veterinary surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sanchez-Teran, Andres F.</au><au>Bracamonte, José L.</au><au>Hendrick, Steven</au><au>Burguess, Hilary J.</au><au>Duke-Novakovski, Tanya</au><au>Schott, Monica</au><au>Hoff, Brent</au><au>Rubio-Martínez, Luis M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Arthroscopic Lavage on Systemic and Synovial Fluid Serum Amyloid A in Healthy Horses</atitle><jtitle>Veterinary surgery</jtitle><addtitle>Veterinary Surgery</addtitle><date>2016-02</date><risdate>2016</risdate><volume>45</volume><issue>2</issue><spage>223</spage><epage>230</epage><pages>223-230</pages><issn>0161-3499</issn><eissn>1532-950X</eissn><abstract>OBJECTIVE: To evaluate the effect of arthroscopic lavage on systemic serum amyloid A (SAA) and SAA, total protein, nucleated cell count, and percentage of neutrophils in synovial fluid in healthy horses. STUDY DESIGN: Prospective experimental study. ANIMALS: Healthy adult horses (n = 6). METHODS: Middle carpal joints were randomly assigned to 1 of 2 treatments: arthrocentesis (controls) or arthroscopic lavage, with 30 day washout period between treatments. Synovial fluid and blood samples were collected at 0, 24, 48, 72, 96, and 120 hours. Measurements included systemic and synovial fluid SAA, as well as total protein, nucleated cell count, and percentages of neutrophils in synovial fluid. Data were analyzed by median quantile regression and Wilcoxon signed‐rank test and significance level set at P &lt; .05. RESULTS: Systemic and synovial fluid SAA did not increase from baseline (except systemic SAA at 24 hours for both treatments) and were not significantly different between treatments. Total protein values were significantly increased after arthroscopic lavage (except at 96 hours) but not in controls at all time points. With both treatments, nucleated cell counts significantly increased from baseline values at all time points. Percentages of neutrophils were significantly increased after arthroscopic lavage at all time points, but only at 24 hours in controls. CONCLUSION: Total protein, nucleated cell count, and percentage of neutrophils in synovial fluid were significantly increased after arthroscopic lavage; however, synovial fluid SAA was not affected by this procedure. Further research is warranted to validate synovial fluid SAA as a monitoring tool during treatment of septic arthritis.</abstract><cop>United States</cop><pub>Blackwell [etc.]</pub><pmid>26767549</pmid><doi>10.1111/vsu.12439</doi><tpages>8</tpages></addata></record>
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source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Animals
Arthritis
Arthroscopy
Female
Horse Diseases - surgery
Horse Diseases - therapy
Horses
Injections, Intra-Articular - veterinary
Joint Diseases - veterinary
Male
Neutrophils
Prospective Studies
Proteins
Serum Amyloid A Protein - metabolism
Synovial Fluid - cytology
Synovial Fluid - metabolism
Therapeutic Irrigation - veterinary
Veterinary medicine
title Effect of Arthroscopic Lavage on Systemic and Synovial Fluid Serum Amyloid A in Healthy Horses
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