Analysis of killer cell immunoglobulin-like receptors and their human leukocyte antigen-ligands gene polymorphisms in Iranian patients with systemic lupus erythematosus
Objective Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease. Natural killer (NK) cells play a critical role in the pathogenesis of autoimmune disorders that mainly express killer cell immunoglobulin-like receptors (KIRs). The present study was undertaken to determine the assoc...
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| Veröffentlicht in: | Lupus 2016-10, Vol.25 (11), p.1244-1253 |
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| creator | Akhtari, M Farazmand, A Mahmoudi, M Akbarian, M Ahmadzadeh, N Mirkazemi, Z Mostafaei, S Jamshidi, A R |
| description | Objective
Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease. Natural killer (NK) cells play a critical role in the pathogenesis of autoimmune disorders that mainly express killer cell immunoglobulin-like receptors (KIRs). The present study was undertaken to determine the association of the KIR alleles, genotypes, and KIR–human leukocyte antigen (HLA) ligand gene combinations with the susceptibility to SLE.
Methods
The genotyping of 17 KIR and 5 HLA loci was performed using the polymerase chain reaction-sequence specific primer (PCR-SSP) method. The study population consisted of 230 SLE patients and 273 ethnical-, age-, and sex-matched healthy controls. The association of the polymorphisms with the prevalence of 11 clinical criteria in patients was analyzed.
Results
The carrier frequency of HLA-A-Bw4 was modestly decreased in the SLE patients. The prevalence of hematological and renal disorders was significantly increased in patients with combination of KIR3DL1+; HLA-B-Bw4Thr80+ and KIR2DS1+; HLA-C2+ genes, respectively. Female patients with combination of KIR2DL2+; HLA-C1− genes were more likely to develop serositis. In addition the prevalence of renal disorders, oral ulcer and serositis was significantly increased in male patients with KIR3DP1+, KIR2DS1+, and KIR2DS3+ genotypes respectively.
Conclusion
Our results showed that the presence of activating KIR receptors alone or in combination with their HLA ligands and the absence of inhibitory KIRs in combination with their HLA ligands may activate NK cells and are significantly correlated with the prevalence of renal disease, hematologic disorders, serositis, and oral ulcer in SLE patients. |
| doi_str_mv | 10.1177/0961203316638931 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1827910533</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0961203316638931</sage_id><sourcerecordid>1819433082</sourcerecordid><originalsourceid>FETCH-LOGICAL-c398t-547e3cd7578589e7ee23dfcd7ed3e38613fe4dab3b687a9c83367ec53d4570df3</originalsourceid><addsrcrecordid>eNqNkc2L1TAUxYsoznN070oCbtxUk6bNx3IY_BgYcKPrktfevpd5SVNzE6T_kX-mqW8UGRBcJdzzO-fCPVX1ktG3jEn5jmrBGso5E4IrzdmjasdaKesybx5Xu02uN_2ieoZ4RynlTIun1UUjtNJMyF3142o2bkWLJEzkZJ2DSAZwjljv8xwOLuyzs3Pt7AlIhAGWFCISM48kHcFGcszezMRBPoVhTVCUZA-wGQ4FQlL-QJbgVh_icrTokdiZ3EQz2-JbTLIwJyTfbToSXDGBtwNxeclIIK5lhzcpYMbn1ZPJOIQX9-9l9fXD-y_Xn-rbzx9vrq9u64FrlequlcCHUXZSdUqDBGj4OJUBjBy4EoxP0I5mz_dCSaMHxbmQMHR8bDtJx4lfVm_OuUsM3zJg6r3F7SJmhpCxZ6qRmtGO8_9AmW45p6op6OsH6F3IsZz-F6U6IQTVhaJnaogBMcLUL9F6E9ee0X4rvH9YeLG8ug_Oew_jH8PvhgtQnwE0B_hr678CfwJMcbcb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1818566609</pqid></control><display><type>article</type><title>Analysis of killer cell immunoglobulin-like receptors and their human leukocyte antigen-ligands gene polymorphisms in Iranian patients with systemic lupus erythematosus</title><source>Access via SAGE</source><source>MEDLINE</source><creator>Akhtari, M ; Farazmand, A ; Mahmoudi, M ; Akbarian, M ; Ahmadzadeh, N ; Mirkazemi, Z ; Mostafaei, S ; Jamshidi, A R</creator><creatorcontrib>Akhtari, M ; Farazmand, A ; Mahmoudi, M ; Akbarian, M ; Ahmadzadeh, N ; Mirkazemi, Z ; Mostafaei, S ; Jamshidi, A R</creatorcontrib><description>Objective
Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease. Natural killer (NK) cells play a critical role in the pathogenesis of autoimmune disorders that mainly express killer cell immunoglobulin-like receptors (KIRs). The present study was undertaken to determine the association of the KIR alleles, genotypes, and KIR–human leukocyte antigen (HLA) ligand gene combinations with the susceptibility to SLE.
Methods
The genotyping of 17 KIR and 5 HLA loci was performed using the polymerase chain reaction-sequence specific primer (PCR-SSP) method. The study population consisted of 230 SLE patients and 273 ethnical-, age-, and sex-matched healthy controls. The association of the polymorphisms with the prevalence of 11 clinical criteria in patients was analyzed.
Results
The carrier frequency of HLA-A-Bw4 was modestly decreased in the SLE patients. The prevalence of hematological and renal disorders was significantly increased in patients with combination of KIR3DL1+; HLA-B-Bw4Thr80+ and KIR2DS1+; HLA-C2+ genes, respectively. Female patients with combination of KIR2DL2+; HLA-C1− genes were more likely to develop serositis. In addition the prevalence of renal disorders, oral ulcer and serositis was significantly increased in male patients with KIR3DP1+, KIR2DS1+, and KIR2DS3+ genotypes respectively.
Conclusion
Our results showed that the presence of activating KIR receptors alone or in combination with their HLA ligands and the absence of inhibitory KIRs in combination with their HLA ligands may activate NK cells and are significantly correlated with the prevalence of renal disease, hematologic disorders, serositis, and oral ulcer in SLE patients.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203316638931</identifier><identifier>PMID: 26989167</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Antigens ; European Continental Ancestry Group - genetics ; Female ; HLA-A Antigens - genetics ; Humans ; Immunoglobulins ; Iran - epidemiology ; Ligands ; Lupus ; Lupus Erythematosus, Systemic - genetics ; Lupus Erythematosus, Systemic - immunology ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Polymorphism, Single-Stranded Conformational ; Receptors, KIR - genetics ; Ulcers</subject><ispartof>Lupus, 2016-10, Vol.25 (11), p.1244-1253</ispartof><rights>The Author(s) 2016</rights><rights>The Author(s) 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-547e3cd7578589e7ee23dfcd7ed3e38613fe4dab3b687a9c83367ec53d4570df3</citedby><cites>FETCH-LOGICAL-c398t-547e3cd7578589e7ee23dfcd7ed3e38613fe4dab3b687a9c83367ec53d4570df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0961203316638931$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0961203316638931$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21824,27929,27930,43626,43627</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26989167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akhtari, M</creatorcontrib><creatorcontrib>Farazmand, A</creatorcontrib><creatorcontrib>Mahmoudi, M</creatorcontrib><creatorcontrib>Akbarian, M</creatorcontrib><creatorcontrib>Ahmadzadeh, N</creatorcontrib><creatorcontrib>Mirkazemi, Z</creatorcontrib><creatorcontrib>Mostafaei, S</creatorcontrib><creatorcontrib>Jamshidi, A R</creatorcontrib><title>Analysis of killer cell immunoglobulin-like receptors and their human leukocyte antigen-ligands gene polymorphisms in Iranian patients with systemic lupus erythematosus</title><title>Lupus</title><addtitle>Lupus</addtitle><description>Objective
Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease. Natural killer (NK) cells play a critical role in the pathogenesis of autoimmune disorders that mainly express killer cell immunoglobulin-like receptors (KIRs). The present study was undertaken to determine the association of the KIR alleles, genotypes, and KIR–human leukocyte antigen (HLA) ligand gene combinations with the susceptibility to SLE.
Methods
The genotyping of 17 KIR and 5 HLA loci was performed using the polymerase chain reaction-sequence specific primer (PCR-SSP) method. The study population consisted of 230 SLE patients and 273 ethnical-, age-, and sex-matched healthy controls. The association of the polymorphisms with the prevalence of 11 clinical criteria in patients was analyzed.
Results
The carrier frequency of HLA-A-Bw4 was modestly decreased in the SLE patients. The prevalence of hematological and renal disorders was significantly increased in patients with combination of KIR3DL1+; HLA-B-Bw4Thr80+ and KIR2DS1+; HLA-C2+ genes, respectively. Female patients with combination of KIR2DL2+; HLA-C1− genes were more likely to develop serositis. In addition the prevalence of renal disorders, oral ulcer and serositis was significantly increased in male patients with KIR3DP1+, KIR2DS1+, and KIR2DS3+ genotypes respectively.
Conclusion
Our results showed that the presence of activating KIR receptors alone or in combination with their HLA ligands and the absence of inhibitory KIRs in combination with their HLA ligands may activate NK cells and are significantly correlated with the prevalence of renal disease, hematologic disorders, serositis, and oral ulcer in SLE patients.</description><subject>Adult</subject><subject>Antigens</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>HLA-A Antigens - genetics</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Iran - epidemiology</subject><subject>Ligands</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - genetics</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Polymorphism, Single-Stranded Conformational</subject><subject>Receptors, KIR - genetics</subject><subject>Ulcers</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2L1TAUxYsoznN070oCbtxUk6bNx3IY_BgYcKPrktfevpd5SVNzE6T_kX-mqW8UGRBcJdzzO-fCPVX1ktG3jEn5jmrBGso5E4IrzdmjasdaKesybx5Xu02uN_2ieoZ4RynlTIun1UUjtNJMyF3142o2bkWLJEzkZJ2DSAZwjljv8xwOLuyzs3Pt7AlIhAGWFCISM48kHcFGcszezMRBPoVhTVCUZA-wGQ4FQlL-QJbgVh_icrTokdiZ3EQz2-JbTLIwJyTfbToSXDGBtwNxeclIIK5lhzcpYMbn1ZPJOIQX9-9l9fXD-y_Xn-rbzx9vrq9u64FrlequlcCHUXZSdUqDBGj4OJUBjBy4EoxP0I5mz_dCSaMHxbmQMHR8bDtJx4lfVm_OuUsM3zJg6r3F7SJmhpCxZ6qRmtGO8_9AmW45p6op6OsH6F3IsZz-F6U6IQTVhaJnaogBMcLUL9F6E9ee0X4rvH9YeLG8ug_Oew_jH8PvhgtQnwE0B_hr678CfwJMcbcb</recordid><startdate>201610</startdate><enddate>201610</enddate><creator>Akhtari, M</creator><creator>Farazmand, A</creator><creator>Mahmoudi, M</creator><creator>Akbarian, M</creator><creator>Ahmadzadeh, N</creator><creator>Mirkazemi, Z</creator><creator>Mostafaei, S</creator><creator>Jamshidi, A R</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201610</creationdate><title>Analysis of killer cell immunoglobulin-like receptors and their human leukocyte antigen-ligands gene polymorphisms in Iranian patients with systemic lupus erythematosus</title><author>Akhtari, M ; Farazmand, A ; Mahmoudi, M ; Akbarian, M ; Ahmadzadeh, N ; Mirkazemi, Z ; Mostafaei, S ; Jamshidi, A R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-547e3cd7578589e7ee23dfcd7ed3e38613fe4dab3b687a9c83367ec53d4570df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Antigens</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>HLA-A Antigens - genetics</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Iran - epidemiology</topic><topic>Ligands</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - genetics</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Polymorphism, Single-Stranded Conformational</topic><topic>Receptors, KIR - genetics</topic><topic>Ulcers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akhtari, M</creatorcontrib><creatorcontrib>Farazmand, A</creatorcontrib><creatorcontrib>Mahmoudi, M</creatorcontrib><creatorcontrib>Akbarian, M</creatorcontrib><creatorcontrib>Ahmadzadeh, N</creatorcontrib><creatorcontrib>Mirkazemi, Z</creatorcontrib><creatorcontrib>Mostafaei, S</creatorcontrib><creatorcontrib>Jamshidi, A R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akhtari, M</au><au>Farazmand, A</au><au>Mahmoudi, M</au><au>Akbarian, M</au><au>Ahmadzadeh, N</au><au>Mirkazemi, Z</au><au>Mostafaei, S</au><au>Jamshidi, A R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of killer cell immunoglobulin-like receptors and their human leukocyte antigen-ligands gene polymorphisms in Iranian patients with systemic lupus erythematosus</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2016-10</date><risdate>2016</risdate><volume>25</volume><issue>11</issue><spage>1244</spage><epage>1253</epage><pages>1244-1253</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>Objective
Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease. Natural killer (NK) cells play a critical role in the pathogenesis of autoimmune disorders that mainly express killer cell immunoglobulin-like receptors (KIRs). The present study was undertaken to determine the association of the KIR alleles, genotypes, and KIR–human leukocyte antigen (HLA) ligand gene combinations with the susceptibility to SLE.
Methods
The genotyping of 17 KIR and 5 HLA loci was performed using the polymerase chain reaction-sequence specific primer (PCR-SSP) method. The study population consisted of 230 SLE patients and 273 ethnical-, age-, and sex-matched healthy controls. The association of the polymorphisms with the prevalence of 11 clinical criteria in patients was analyzed.
Results
The carrier frequency of HLA-A-Bw4 was modestly decreased in the SLE patients. The prevalence of hematological and renal disorders was significantly increased in patients with combination of KIR3DL1+; HLA-B-Bw4Thr80+ and KIR2DS1+; HLA-C2+ genes, respectively. Female patients with combination of KIR2DL2+; HLA-C1− genes were more likely to develop serositis. In addition the prevalence of renal disorders, oral ulcer and serositis was significantly increased in male patients with KIR3DP1+, KIR2DS1+, and KIR2DS3+ genotypes respectively.
Conclusion
Our results showed that the presence of activating KIR receptors alone or in combination with their HLA ligands and the absence of inhibitory KIRs in combination with their HLA ligands may activate NK cells and are significantly correlated with the prevalence of renal disease, hematologic disorders, serositis, and oral ulcer in SLE patients.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>26989167</pmid><doi>10.1177/0961203316638931</doi><tpages>10</tpages></addata></record> |
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| ispartof | Lupus, 2016-10, Vol.25 (11), p.1244-1253 |
| issn | 0961-2033 1477-0962 |
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| subjects | Adult Antigens European Continental Ancestry Group - genetics Female HLA-A Antigens - genetics Humans Immunoglobulins Iran - epidemiology Ligands Lupus Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Male Middle Aged Polymorphism, Single Nucleotide Polymorphism, Single-Stranded Conformational Receptors, KIR - genetics Ulcers |
| title | Analysis of killer cell immunoglobulin-like receptors and their human leukocyte antigen-ligands gene polymorphisms in Iranian patients with systemic lupus erythematosus |
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