Simultaneous quantification of mycophenolic acid and its glucuronide metabolites in human plasma by an UPLC-MS/MS assay

The aim of this study was to develop a reliable UPLC–MS/MS assay for accurate quantification of mycophenolic acid (MPA) and its glucuronide conjugates in human plasma. Plasma proteins were precipitated with acetonitrile and the chromatographic separation was achieved on a C18 column with a gradient...

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Veröffentlicht in:	Biomedical chromatography 2016-10, Vol.30 (10), p.1648-1655
Hauptverfasser:	Zhang, Daping, Chow, Diana S-L., Renbarger, Jamie L.
Format:	Artikel
Sprache:	eng
Schlagworte:	acyl mycophenolic acid glucuronide Chromatography, Liquid - methods Glucuronides - blood Humans mycophenolic acid Mycophenolic Acid - blood mycophenolic acid glucuronide Reference Standards Reproducibility of Results stability Tandem Mass Spectrometry - methods UPLC-MS/MS
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