Correlation between diabetic retinopathy severity and elevated skin autofluorescence as a marker of advanced glycation end-product accumulation in type 2 diabetic patients
Abstract Aims We evaluated skin autofluorescence (AF) as a marker of tissue advanced glycation end-product (AGE) accumulation and examined whether it was related to the prevalence and severity of diabetic retinopathy (DR) and of diabetic macular edema (DME) in patients with type 2 diabetes mellitus...
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| Veröffentlicht in: | Journal of diabetes and its complications 2014-09, Vol.28 (5), p.729-734 |
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| container_title | Journal of diabetes and its complications |
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| creator | Hirano, Takao Iesato, Yasuhiro Toriyama, Yuichi Imai, Akira Chiba, Dai Murata, Toshinori |
| description | Abstract Aims We evaluated skin autofluorescence (AF) as a marker of tissue advanced glycation end-product (AGE) accumulation and examined whether it was related to the prevalence and severity of diabetic retinopathy (DR) and of diabetic macular edema (DME) in patients with type 2 diabetes mellitus (DM). Methods This study included 138 type 2 DM patients consisting of 31 patients with proliferative DR, 71 patients with non-proliferative DR, and 36 patients without retinopathy, in addition to 111 non-DM control subjects. At the time of skin AF and HbA1c measurement, self-assessed duration of DM was also determined. DR and DME stages were classified according to international guidelines. Results Skin AF was significantly increased in patients with DM as compared with non-DM controls. Furthermore, skin AF was correlated with the severity of DR, whereas single measurement of HbA1c and self-assessed DM duration were not. None of these 3 factors showed a correlation with DME prevalence or severity. Conclusions Skin AF levels, which can be measured non-invasively on a screening basis without skin biopsy or blood sampling, have a greater predictive ability for the presence and severity of DR than single measurement of HbA1c or self-assessed DM duration in patients with type 2 DM. |
| doi_str_mv | 10.1016/j.jdiacomp.2014.03.003 |
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Methods This study included 138 type 2 DM patients consisting of 31 patients with proliferative DR, 71 patients with non-proliferative DR, and 36 patients without retinopathy, in addition to 111 non-DM control subjects. At the time of skin AF and HbA1c measurement, self-assessed duration of DM was also determined. DR and DME stages were classified according to international guidelines. Results Skin AF was significantly increased in patients with DM as compared with non-DM controls. Furthermore, skin AF was correlated with the severity of DR, whereas single measurement of HbA1c and self-assessed DM duration were not. None of these 3 factors showed a correlation with DME prevalence or severity. Conclusions Skin AF levels, which can be measured non-invasively on a screening basis without skin biopsy or blood sampling, have a greater predictive ability for the presence and severity of DR than single measurement of HbA1c or self-assessed DM duration in patients with type 2 DM.</description><identifier>ISSN: 1056-8727</identifier><identifier>EISSN: 1873-460X</identifier><identifier>DOI: 10.1016/j.jdiacomp.2014.03.003</identifier><identifier>PMID: 24795072</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Advanced glycation end-product ; Age ; Aged ; Biomarkers - analysis ; Blood pressure ; Case-Control Studies ; Cross-Sectional Studies ; Diabetes ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - metabolism ; Diabetic macular edema ; Diabetic neuropathy ; Diabetic retinopathy ; Diabetic Retinopathy - diagnosis ; Diabetic Retinopathy - epidemiology ; Endocrinology & Metabolism ; Female ; Fluorescence ; Glycation End Products, Advanced - metabolism ; Humans ; Hyperglycemia ; Male ; Middle Aged ; Predictive Value of Tests ; Prevalence ; Prognosis ; Retina ; Severity of Illness Index ; Skin - metabolism ; Skin - physiopathology ; Skin autofluorescence ; Type 2 diabetes mellitus ; Vascular endothelial growth factor</subject><ispartof>Journal of diabetes and its complications, 2014-09, Vol.28 (5), p.729-734</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Sep 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c620t-fe9dc6e14b65fa823dc87d4926cf00501bee46f78d151e5c4f7b92506f26e2d23</citedby><cites>FETCH-LOGICAL-c620t-fe9dc6e14b65fa823dc87d4926cf00501bee46f78d151e5c4f7b92506f26e2d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1555026894?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24795072$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirano, Takao</creatorcontrib><creatorcontrib>Iesato, Yasuhiro</creatorcontrib><creatorcontrib>Toriyama, Yuichi</creatorcontrib><creatorcontrib>Imai, Akira</creatorcontrib><creatorcontrib>Chiba, Dai</creatorcontrib><creatorcontrib>Murata, Toshinori</creatorcontrib><title>Correlation between diabetic retinopathy severity and elevated skin autofluorescence as a marker of advanced glycation end-product accumulation in type 2 diabetic patients</title><title>Journal of diabetes and its complications</title><addtitle>J Diabetes Complications</addtitle><description>Abstract Aims We evaluated skin autofluorescence (AF) as a marker of tissue advanced glycation end-product (AGE) accumulation and examined whether it was related to the prevalence and severity of diabetic retinopathy (DR) and of diabetic macular edema (DME) in patients with type 2 diabetes mellitus (DM). Methods This study included 138 type 2 DM patients consisting of 31 patients with proliferative DR, 71 patients with non-proliferative DR, and 36 patients without retinopathy, in addition to 111 non-DM control subjects. At the time of skin AF and HbA1c measurement, self-assessed duration of DM was also determined. DR and DME stages were classified according to international guidelines. Results Skin AF was significantly increased in patients with DM as compared with non-DM controls. Furthermore, skin AF was correlated with the severity of DR, whereas single measurement of HbA1c and self-assessed DM duration were not. None of these 3 factors showed a correlation with DME prevalence or severity. Conclusions Skin AF levels, which can be measured non-invasively on a screening basis without skin biopsy or blood sampling, have a greater predictive ability for the presence and severity of DR than single measurement of HbA1c or self-assessed DM duration in patients with type 2 DM.</description><subject>Advanced glycation end-product</subject><subject>Age</subject><subject>Aged</subject><subject>Biomarkers - analysis</subject><subject>Blood pressure</subject><subject>Case-Control Studies</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetic macular edema</subject><subject>Diabetic neuropathy</subject><subject>Diabetic retinopathy</subject><subject>Diabetic Retinopathy - diagnosis</subject><subject>Diabetic Retinopathy - epidemiology</subject><subject>Endocrinology & Metabolism</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Glycation End Products, Advanced - metabolism</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Retina</subject><subject>Severity of Illness Index</subject><subject>Skin - metabolism</subject><subject>Skin - physiopathology</subject><subject>Skin autofluorescence</subject><subject>Type 2 diabetes mellitus</subject><subject>Vascular endothelial growth factor</subject><issn>1056-8727</issn><issn>1873-460X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNksuKFDEUhgtRnHH0FYaAGzfVnqQqqdRGlMYbDLhQwV1IJ6c03dVJm6Ra6pl8SVN0jwOz0U0Swnf-c_lPVV1TWFGg4uV2tbVOm7A_rBjQdgXNCqB5UF1S2TV1K-Dbw_IGLmrZse6iepLSFgAE5_RxdcHarufQscvq9zrEiKPOLniywfwL0ZOiXJ7OkFhOHw46_5hJwiNGl2eivSU44lFntCTtnCd6ymEYpxAxGfQGiU5Ek72OO4wkDETboy7flnwfZ3NKhd7WhxjsZDLRxkz76VxDkcvzAQm7q6Lkd-hzelo9GvSY8Nn5vqq-vnv7Zf2hvvn0_uP6zU1tBINcD9hbI5C2G8EHLVljjexs2zNhBgAOdIPYiqGTlnKK3LRDt-kZBzEwgcyy5qp6cdItBf6cMGW1d6WxcdQew5QUlazroaPsP1DOBZON5LKgz--h2zBFXxpZKA5MyL4tlDhRJoaUIg7qEF2Z5KwoqMV5tVW3zqvFeQWNKs6XwOuz_LTZo_0bdmt1AV6fACyjOzqMKhm3uGVdRJOVDe7fOV7dkzCj887ocYczprt-VGIK1Odl_5b1o21ZPS6h-QNLRNsc</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Hirano, Takao</creator><creator>Iesato, Yasuhiro</creator><creator>Toriyama, Yuichi</creator><creator>Imai, Akira</creator><creator>Chiba, Dai</creator><creator>Murata, Toshinori</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20140901</creationdate><title>Correlation between diabetic retinopathy severity and elevated skin autofluorescence as a marker of advanced glycation end-product accumulation in type 2 diabetic patients</title><author>Hirano, Takao ; Iesato, Yasuhiro ; Toriyama, Yuichi ; Imai, Akira ; Chiba, Dai ; Murata, Toshinori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c620t-fe9dc6e14b65fa823dc87d4926cf00501bee46f78d151e5c4f7b92506f26e2d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Advanced glycation end-product</topic><topic>Age</topic><topic>Aged</topic><topic>Biomarkers - analysis</topic><topic>Blood pressure</topic><topic>Case-Control Studies</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetic macular edema</topic><topic>Diabetic neuropathy</topic><topic>Diabetic retinopathy</topic><topic>Diabetic Retinopathy - diagnosis</topic><topic>Diabetic Retinopathy - epidemiology</topic><topic>Endocrinology & Metabolism</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Glycation End Products, Advanced - metabolism</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Retina</topic><topic>Severity of Illness Index</topic><topic>Skin - metabolism</topic><topic>Skin - physiopathology</topic><topic>Skin autofluorescence</topic><topic>Type 2 diabetes mellitus</topic><topic>Vascular endothelial growth factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirano, Takao</creatorcontrib><creatorcontrib>Iesato, Yasuhiro</creatorcontrib><creatorcontrib>Toriyama, Yuichi</creatorcontrib><creatorcontrib>Imai, Akira</creatorcontrib><creatorcontrib>Chiba, Dai</creatorcontrib><creatorcontrib>Murata, Toshinori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>British Nursing Index</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of diabetes and its complications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirano, Takao</au><au>Iesato, Yasuhiro</au><au>Toriyama, Yuichi</au><au>Imai, Akira</au><au>Chiba, Dai</au><au>Murata, Toshinori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between diabetic retinopathy severity and elevated skin autofluorescence as a marker of advanced glycation end-product accumulation in type 2 diabetic patients</atitle><jtitle>Journal of diabetes and its complications</jtitle><addtitle>J Diabetes Complications</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>28</volume><issue>5</issue><spage>729</spage><epage>734</epage><pages>729-734</pages><issn>1056-8727</issn><eissn>1873-460X</eissn><abstract>Abstract Aims We evaluated skin autofluorescence (AF) as a marker of tissue advanced glycation end-product (AGE) accumulation and examined whether it was related to the prevalence and severity of diabetic retinopathy (DR) and of diabetic macular edema (DME) in patients with type 2 diabetes mellitus (DM). Methods This study included 138 type 2 DM patients consisting of 31 patients with proliferative DR, 71 patients with non-proliferative DR, and 36 patients without retinopathy, in addition to 111 non-DM control subjects. At the time of skin AF and HbA1c measurement, self-assessed duration of DM was also determined. DR and DME stages were classified according to international guidelines. Results Skin AF was significantly increased in patients with DM as compared with non-DM controls. Furthermore, skin AF was correlated with the severity of DR, whereas single measurement of HbA1c and self-assessed DM duration were not. None of these 3 factors showed a correlation with DME prevalence or severity. Conclusions Skin AF levels, which can be measured non-invasively on a screening basis without skin biopsy or blood sampling, have a greater predictive ability for the presence and severity of DR than single measurement of HbA1c or self-assessed DM duration in patients with type 2 DM.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24795072</pmid><doi>10.1016/j.jdiacomp.2014.03.003</doi><tpages>6</tpages></addata></record> |
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| subjects | Advanced glycation end-product Age Aged Biomarkers - analysis Blood pressure Case-Control Studies Cross-Sectional Studies Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - metabolism Diabetic macular edema Diabetic neuropathy Diabetic retinopathy Diabetic Retinopathy - diagnosis Diabetic Retinopathy - epidemiology Endocrinology & Metabolism Female Fluorescence Glycation End Products, Advanced - metabolism Humans Hyperglycemia Male Middle Aged Predictive Value of Tests Prevalence Prognosis Retina Severity of Illness Index Skin - metabolism Skin - physiopathology Skin autofluorescence Type 2 diabetes mellitus Vascular endothelial growth factor |
| title | Correlation between diabetic retinopathy severity and elevated skin autofluorescence as a marker of advanced glycation end-product accumulation in type 2 diabetic patients |
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