Effects of nasal drug delivery device and its orientation on sprayed particle deposition in a realistic human nasal cavity
Abstract In this study, the effects of nasal drug delivery device and the spray nozzle orientation on sprayed droplets deposition in a realistic human nasal cavity were numerically studied. Prior to performing the numerical investigation, an in-house designed automated actuation system representing...
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| Veröffentlicht in: | Computers in biology and medicine 2016-10, Vol.77, p.40-48 |
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| creator | Tong, Xuwen Dong, Jingliang Shang, Yidan Inthavong, Kiao Tu, Jiyuan |
| description | Abstract In this study, the effects of nasal drug delivery device and the spray nozzle orientation on sprayed droplets deposition in a realistic human nasal cavity were numerically studied. Prior to performing the numerical investigation, an in-house designed automated actuation system representing mean adults actuation force was developed to produce realistic spray plume. Then, the spray plume development was filmed by high speed photography system, and spray characteristics such as spray cone angle, break-up length, and average droplet velocity were obtained through off-line image analysis. Continuing studies utilizing those experimental data as boundary conditions were applied in the following numerical spray simulations using a commercially available nasal spray device, which was inserted into a realistic adult nasal passage with external facial features. Through varying the particle releasing direction, the deposition fractions of selected particle sizes on the main nasal passage for targeted drug delivery were compared. The results demonstrated that the middle spray direction showed superior spray efficiency compared with upper or lower directions, and the 10 µm agents were the most suitable particle size as the majority of sprayed agents can be delivered to the targeted area, the main passage. This study elaborates a comprehensive approach to better understand nasal spray mechanism and evaluate its performance for existing nasal delivery practices. Results of this study can assist the pharmaceutical industry to improve the current design of nasal drug delivery device and ultimately benefit more patients through optimized medications delivery. |
| doi_str_mv | 10.1016/j.compbiomed.2016.08.002 |
| format | Article |
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Prior to performing the numerical investigation, an in-house designed automated actuation system representing mean adults actuation force was developed to produce realistic spray plume. Then, the spray plume development was filmed by high speed photography system, and spray characteristics such as spray cone angle, break-up length, and average droplet velocity were obtained through off-line image analysis. Continuing studies utilizing those experimental data as boundary conditions were applied in the following numerical spray simulations using a commercially available nasal spray device, which was inserted into a realistic adult nasal passage with external facial features. Through varying the particle releasing direction, the deposition fractions of selected particle sizes on the main nasal passage for targeted drug delivery were compared. The results demonstrated that the middle spray direction showed superior spray efficiency compared with upper or lower directions, and the 10 µm agents were the most suitable particle size as the majority of sprayed agents can be delivered to the targeted area, the main passage. This study elaborates a comprehensive approach to better understand nasal spray mechanism and evaluate its performance for existing nasal delivery practices. Results of this study can assist the pharmaceutical industry to improve the current design of nasal drug delivery device and ultimately benefit more patients through optimized medications delivery.</description><identifier>ISSN: 0010-4825</identifier><identifier>EISSN: 1879-0534</identifier><identifier>DOI: 10.1016/j.compbiomed.2016.08.002</identifier><identifier>PMID: 27509293</identifier><identifier>CODEN: CBMDAW</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Administration, Intranasal - methods ; Adult ; Aerosols - administration & dosage ; Allergies ; Atomization ; Computer Simulation ; Deposition fraction ; Drug delivery systems ; Drug Delivery Systems - methods ; Equipment Design ; Humans ; Internal Medicine ; Male ; Medications delivery ; Models, Anatomic ; Nasal Cavity - anatomy & histology ; Nasal Cavity - diagnostic imaging ; Nasal spray ; Nose ; Other ; Pharmaceutical industry</subject><ispartof>Computers in biology and medicine, 2016-10, Vol.77, p.40-48</ispartof><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Oct 01, 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c560t-484005c0dd3095f24a243540c665b400619cac1c962b6bb007a55fe9adc731303</citedby><cites>FETCH-LOGICAL-c560t-484005c0dd3095f24a243540c665b400619cac1c962b6bb007a55fe9adc731303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0010482516301937$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27509293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tong, Xuwen</creatorcontrib><creatorcontrib>Dong, Jingliang</creatorcontrib><creatorcontrib>Shang, Yidan</creatorcontrib><creatorcontrib>Inthavong, Kiao</creatorcontrib><creatorcontrib>Tu, Jiyuan</creatorcontrib><title>Effects of nasal drug delivery device and its orientation on sprayed particle deposition in a realistic human nasal cavity</title><title>Computers in biology and medicine</title><addtitle>Comput Biol Med</addtitle><description>Abstract In this study, the effects of nasal drug delivery device and the spray nozzle orientation on sprayed droplets deposition in a realistic human nasal cavity were numerically studied. Prior to performing the numerical investigation, an in-house designed automated actuation system representing mean adults actuation force was developed to produce realistic spray plume. Then, the spray plume development was filmed by high speed photography system, and spray characteristics such as spray cone angle, break-up length, and average droplet velocity were obtained through off-line image analysis. Continuing studies utilizing those experimental data as boundary conditions were applied in the following numerical spray simulations using a commercially available nasal spray device, which was inserted into a realistic adult nasal passage with external facial features. Through varying the particle releasing direction, the deposition fractions of selected particle sizes on the main nasal passage for targeted drug delivery were compared. The results demonstrated that the middle spray direction showed superior spray efficiency compared with upper or lower directions, and the 10 µm agents were the most suitable particle size as the majority of sprayed agents can be delivered to the targeted area, the main passage. This study elaborates a comprehensive approach to better understand nasal spray mechanism and evaluate its performance for existing nasal delivery practices. Results of this study can assist the pharmaceutical industry to improve the current design of nasal drug delivery device and ultimately benefit more patients through optimized medications delivery.</description><subject>Administration, Intranasal - methods</subject><subject>Adult</subject><subject>Aerosols - administration & dosage</subject><subject>Allergies</subject><subject>Atomization</subject><subject>Computer Simulation</subject><subject>Deposition fraction</subject><subject>Drug delivery systems</subject><subject>Drug Delivery Systems - methods</subject><subject>Equipment Design</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medications delivery</subject><subject>Models, Anatomic</subject><subject>Nasal Cavity - anatomy & histology</subject><subject>Nasal Cavity - diagnostic imaging</subject><subject>Nasal spray</subject><subject>Nose</subject><subject>Other</subject><subject>Pharmaceutical industry</subject><issn>0010-4825</issn><issn>1879-0534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk2L1TAUhoMoznX0L0jAjZtbT5KmbTaCDuMHDLhQ1yFNTjXXtqlJe6Hz6029dxiY1UAgIe-T85H3EEIZFAxY9e5Q2DBMrQ8DuoLnmwKaAoA_ITvW1GoPUpRPyQ6Awb5suLwgL1I6AEAJAp6TC15LUFyJHbm97jq0c6Kho6NJpqcuLr-ow94fMa75cPQWqRkd9RsVPY6zmX0YaV5pimZFRycTZ297zPgUkv8v-5EaGtH0PmWN_l4GM55TWHP08_qSPOtMn_DVeb8kPz9d_7j6sr_59vnr1YebvZUVzLn-EkBacE6Akh0vDS-FLMFWlWyzVDFljWVWVbyt2hagNlJ2qIyztWACxCV5e4o7xfB3wTTrwSeLfW9GDEvSrOG1Asnko1BRSp4LyOibB-ghLHHMjWSqrmvFZNNkqjlRNoaUInZ6in4wcdUM9GalPuh7K_VmpYZGZyvz09fnBEu7aXcP77zLwMcTgPnzjh6jTja7Y9H5mC3VLvjHZHn_IIjt_eit6f_gium-J524Bv19G6ltolglgClRi39sNMkj</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Tong, Xuwen</creator><creator>Dong, Jingliang</creator><creator>Shang, Yidan</creator><creator>Inthavong, Kiao</creator><creator>Tu, Jiyuan</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AL</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>JQ2</scope><scope>K7-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0N</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20161001</creationdate><title>Effects of nasal drug delivery device and its orientation on sprayed particle deposition in a realistic human nasal cavity</title><author>Tong, Xuwen ; Dong, Jingliang ; Shang, Yidan ; Inthavong, Kiao ; Tu, Jiyuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c560t-484005c0dd3095f24a243540c665b400619cac1c962b6bb007a55fe9adc731303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Administration, Intranasal - methods</topic><topic>Adult</topic><topic>Aerosols - administration & dosage</topic><topic>Allergies</topic><topic>Atomization</topic><topic>Computer Simulation</topic><topic>Deposition fraction</topic><topic>Drug delivery systems</topic><topic>Drug Delivery Systems - methods</topic><topic>Equipment Design</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medications delivery</topic><topic>Models, Anatomic</topic><topic>Nasal Cavity - anatomy & histology</topic><topic>Nasal Cavity - diagnostic imaging</topic><topic>Nasal spray</topic><topic>Nose</topic><topic>Other</topic><topic>Pharmaceutical industry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tong, Xuwen</creatorcontrib><creatorcontrib>Dong, Jingliang</creatorcontrib><creatorcontrib>Shang, Yidan</creatorcontrib><creatorcontrib>Inthavong, Kiao</creatorcontrib><creatorcontrib>Tu, Jiyuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Computing Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Computer Science Collection</collection><collection>Computer Science Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Computing Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Computers in biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tong, Xuwen</au><au>Dong, Jingliang</au><au>Shang, Yidan</au><au>Inthavong, Kiao</au><au>Tu, Jiyuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of nasal drug delivery device and its orientation on sprayed particle deposition in a realistic human nasal cavity</atitle><jtitle>Computers in biology and medicine</jtitle><addtitle>Comput Biol Med</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>77</volume><spage>40</spage><epage>48</epage><pages>40-48</pages><issn>0010-4825</issn><eissn>1879-0534</eissn><coden>CBMDAW</coden><abstract>Abstract In this study, the effects of nasal drug delivery device and the spray nozzle orientation on sprayed droplets deposition in a realistic human nasal cavity were numerically studied. Prior to performing the numerical investigation, an in-house designed automated actuation system representing mean adults actuation force was developed to produce realistic spray plume. Then, the spray plume development was filmed by high speed photography system, and spray characteristics such as spray cone angle, break-up length, and average droplet velocity were obtained through off-line image analysis. Continuing studies utilizing those experimental data as boundary conditions were applied in the following numerical spray simulations using a commercially available nasal spray device, which was inserted into a realistic adult nasal passage with external facial features. Through varying the particle releasing direction, the deposition fractions of selected particle sizes on the main nasal passage for targeted drug delivery were compared. The results demonstrated that the middle spray direction showed superior spray efficiency compared with upper or lower directions, and the 10 µm agents were the most suitable particle size as the majority of sprayed agents can be delivered to the targeted area, the main passage. This study elaborates a comprehensive approach to better understand nasal spray mechanism and evaluate its performance for existing nasal delivery practices. Results of this study can assist the pharmaceutical industry to improve the current design of nasal drug delivery device and ultimately benefit more patients through optimized medications delivery.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>27509293</pmid><doi>10.1016/j.compbiomed.2016.08.002</doi><tpages>9</tpages></addata></record> |
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| subjects | Administration, Intranasal - methods Adult Aerosols - administration & dosage Allergies Atomization Computer Simulation Deposition fraction Drug delivery systems Drug Delivery Systems - methods Equipment Design Humans Internal Medicine Male Medications delivery Models, Anatomic Nasal Cavity - anatomy & histology Nasal Cavity - diagnostic imaging Nasal spray Nose Other Pharmaceutical industry |
| title | Effects of nasal drug delivery device and its orientation on sprayed particle deposition in a realistic human nasal cavity |
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