Upper airway microbial colonization in patients with neuromuscular disorders
Background and objective Inherited neuromuscular disorders (NMD) inevitably result in severe lung volume restriction and cough insufficiency associated with high morbidity and mortality. The aim of this retrospective study was to evaluate whether the airways of patients with NMD are colonized with p...
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| Veröffentlicht in: | Respirology (Carlton, Vic.) Vic.), 2016-10, Vol.21 (7), p.1285-1291 |
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| creator | Stehling, Florian Pieper, Nadine Bouikidis, Anastasios Steinmann, Joerg Rath, Peter-Michael Mellies, Uwe |
| description | Background and objective
Inherited neuromuscular disorders (NMD) inevitably result in severe lung volume restriction and cough insufficiency associated with high morbidity and mortality. The aim of this retrospective study was to evaluate whether the airways of patients with NMD are colonized with potential pathogenic microorganisms that might contribute to the pulmonary morbidity in NMD.
Methods
In this cross‐sectional study, cough swabs were obtained and cultured for microbiological analyses from 77 patients with NMD and different degrees of lung volume restriction and cough insufficiency. Upper airway microbial colonization was compared to lung function parameters and cough peak flow values.
Results
Upper airway microbial colonization with potential pathogenic pathogens was identified in 39/77 (51%) of the subjects. Upper airway microbial colonization was associated with lower forced vital capacity (% pred.) 26.6 ± 19.7 versus 41.8 ± 20.4, P |
| doi_str_mv | 10.1111/resp.12814 |
| format | Article |
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Inherited neuromuscular disorders (NMD) inevitably result in severe lung volume restriction and cough insufficiency associated with high morbidity and mortality. The aim of this retrospective study was to evaluate whether the airways of patients with NMD are colonized with potential pathogenic microorganisms that might contribute to the pulmonary morbidity in NMD.
Methods
In this cross‐sectional study, cough swabs were obtained and cultured for microbiological analyses from 77 patients with NMD and different degrees of lung volume restriction and cough insufficiency. Upper airway microbial colonization was compared to lung function parameters and cough peak flow values.
Results
Upper airway microbial colonization with potential pathogenic pathogens was identified in 39/77 (51%) of the subjects. Upper airway microbial colonization was associated with lower forced vital capacity (% pred.) 26.6 ± 19.7 versus 41.8 ± 20.4, P < 0.001 and cough peak flow (l/min) 125 ± 55 versus 207 ± 100, P < 0.001. In the subgroup colonized with potential pathogenic Gram‐negative bacteria or Staphylococcus aureus forced vital capacity and cough peak flow remained significantly lower compared with subjects without upper airway colonization (FVC (% pred.): 22.6 ± 16.5 vs 37.9 ± 21.5, P = 0.003; CPF (l/min): 123 ± 60 vs 179 ± 93, P = 0.013).
Conclusion
Severe respiratory compromise in patients with NMD is associated with upper airway microbial airway colonization, which might contribute to respiratory morbidity/insufficiency.
This retrospective data analysis shows for the first time that advanced stages of lung volume restriction and cough insufficiency in patients with neuromuscular disorders are accompanied by microbial airway colonization. Treatment of chronic bacterial colonization/infection may offer a new therapeutic strategy to reduce respiratory morbidity of patients with neuromuscular disorders.</description><identifier>ISSN: 1323-7799</identifier><identifier>EISSN: 1440-1843</identifier><identifier>DOI: 10.1111/resp.12814</identifier><identifier>PMID: 27221716</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; airway colonization ; Child ; Cough - microbiology ; Cough - physiopathology ; cough insufficiency ; Cross-Sectional Studies ; Duchenne muscular dystrophy ; Female ; Humans ; lung function ; Lung Volume Measurements ; Male ; Neuromuscular Diseases - complications ; Neuromuscular Diseases - microbiology ; Neuromuscular Diseases - physiopathology ; neuromuscular disorders ; Respiratory Insufficiency - etiology ; Retrospective Studies ; Staphylococcus aureus ; Tidal Volume ; Young Adult</subject><ispartof>Respirology (Carlton, Vic.), 2016-10, Vol.21 (7), p.1285-1291</ispartof><rights>2016 Asian Pacific Society of Respirology</rights><rights>2016 Asian Pacific Society of Respirology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4704-8d52aa3ab039e3d1a65e26e1af67bdb0482b342ae90fc899959f5a61476019353</citedby><cites>FETCH-LOGICAL-c4704-8d52aa3ab039e3d1a65e26e1af67bdb0482b342ae90fc899959f5a61476019353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fresp.12814$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fresp.12814$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27221716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stehling, Florian</creatorcontrib><creatorcontrib>Pieper, Nadine</creatorcontrib><creatorcontrib>Bouikidis, Anastasios</creatorcontrib><creatorcontrib>Steinmann, Joerg</creatorcontrib><creatorcontrib>Rath, Peter-Michael</creatorcontrib><creatorcontrib>Mellies, Uwe</creatorcontrib><title>Upper airway microbial colonization in patients with neuromuscular disorders</title><title>Respirology (Carlton, Vic.)</title><addtitle>Respirology</addtitle><description>Background and objective
Inherited neuromuscular disorders (NMD) inevitably result in severe lung volume restriction and cough insufficiency associated with high morbidity and mortality. The aim of this retrospective study was to evaluate whether the airways of patients with NMD are colonized with potential pathogenic microorganisms that might contribute to the pulmonary morbidity in NMD.
Methods
In this cross‐sectional study, cough swabs were obtained and cultured for microbiological analyses from 77 patients with NMD and different degrees of lung volume restriction and cough insufficiency. Upper airway microbial colonization was compared to lung function parameters and cough peak flow values.
Results
Upper airway microbial colonization with potential pathogenic pathogens was identified in 39/77 (51%) of the subjects. Upper airway microbial colonization was associated with lower forced vital capacity (% pred.) 26.6 ± 19.7 versus 41.8 ± 20.4, P < 0.001 and cough peak flow (l/min) 125 ± 55 versus 207 ± 100, P < 0.001. In the subgroup colonized with potential pathogenic Gram‐negative bacteria or Staphylococcus aureus forced vital capacity and cough peak flow remained significantly lower compared with subjects without upper airway colonization (FVC (% pred.): 22.6 ± 16.5 vs 37.9 ± 21.5, P = 0.003; CPF (l/min): 123 ± 60 vs 179 ± 93, P = 0.013).
Conclusion
Severe respiratory compromise in patients with NMD is associated with upper airway microbial airway colonization, which might contribute to respiratory morbidity/insufficiency.
This retrospective data analysis shows for the first time that advanced stages of lung volume restriction and cough insufficiency in patients with neuromuscular disorders are accompanied by microbial airway colonization. Treatment of chronic bacterial colonization/infection may offer a new therapeutic strategy to reduce respiratory morbidity of patients with neuromuscular disorders.</description><subject>Adolescent</subject><subject>Adult</subject><subject>airway colonization</subject><subject>Child</subject><subject>Cough - microbiology</subject><subject>Cough - physiopathology</subject><subject>cough insufficiency</subject><subject>Cross-Sectional Studies</subject><subject>Duchenne muscular dystrophy</subject><subject>Female</subject><subject>Humans</subject><subject>lung function</subject><subject>Lung Volume Measurements</subject><subject>Male</subject><subject>Neuromuscular Diseases - complications</subject><subject>Neuromuscular Diseases - microbiology</subject><subject>Neuromuscular Diseases - physiopathology</subject><subject>neuromuscular disorders</subject><subject>Respiratory Insufficiency - etiology</subject><subject>Retrospective Studies</subject><subject>Staphylococcus aureus</subject><subject>Tidal Volume</subject><subject>Young Adult</subject><issn>1323-7799</issn><issn>1440-1843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMlOwzAQQC0EYilc-ACUI0JK8RrHR4RKAVWlLFWPlpNMhCEbdqJSvp6UAkeELzOHN0_WQ-iY4CHp37kD3wwJjQnfQvuEcxySmLPtfmeUhVIqtYcOvH_BGDOBxS7ao5JSIkm0jybzpgEXGOuWZhWUNnV1Yk0RpHVRV_bDtLauAlsFTb9B1fpgadvnoILO1WXn064wLsisr10Gzh-indwUHo6-5wDNr0ZPl9fh5G58c3kxCVMuMQ_jTFBjmEkwU8AyYiIBNAJi8kgmWYJ5TBPGqQGF8zRWSgmVCxMRLiNMFBNsgE433sbVbx34VpfWp1AUpoK685rEVCosMI3_gRKl-n-otfVsg_YNvHeQ68bZ0riVJlivQ-t1aP0VuodPvr1dUkL2i_6U7QGyAZa2gNUfKv0wepz9SMPNjfUtvP_eGPeqI8mk0IvpWN-ymXqa3S_0lH0C89aYBA</recordid><startdate>201610</startdate><enddate>201610</enddate><creator>Stehling, Florian</creator><creator>Pieper, Nadine</creator><creator>Bouikidis, Anastasios</creator><creator>Steinmann, Joerg</creator><creator>Rath, Peter-Michael</creator><creator>Mellies, Uwe</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201610</creationdate><title>Upper airway microbial colonization in patients with neuromuscular disorders</title><author>Stehling, Florian ; Pieper, Nadine ; Bouikidis, Anastasios ; Steinmann, Joerg ; Rath, Peter-Michael ; Mellies, Uwe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4704-8d52aa3ab039e3d1a65e26e1af67bdb0482b342ae90fc899959f5a61476019353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>airway colonization</topic><topic>Child</topic><topic>Cough - microbiology</topic><topic>Cough - physiopathology</topic><topic>cough insufficiency</topic><topic>Cross-Sectional Studies</topic><topic>Duchenne muscular dystrophy</topic><topic>Female</topic><topic>Humans</topic><topic>lung function</topic><topic>Lung Volume Measurements</topic><topic>Male</topic><topic>Neuromuscular Diseases - complications</topic><topic>Neuromuscular Diseases - microbiology</topic><topic>Neuromuscular Diseases - physiopathology</topic><topic>neuromuscular disorders</topic><topic>Respiratory Insufficiency - etiology</topic><topic>Retrospective Studies</topic><topic>Staphylococcus aureus</topic><topic>Tidal Volume</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stehling, Florian</creatorcontrib><creatorcontrib>Pieper, Nadine</creatorcontrib><creatorcontrib>Bouikidis, Anastasios</creatorcontrib><creatorcontrib>Steinmann, Joerg</creatorcontrib><creatorcontrib>Rath, Peter-Michael</creatorcontrib><creatorcontrib>Mellies, Uwe</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Respirology (Carlton, Vic.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stehling, Florian</au><au>Pieper, Nadine</au><au>Bouikidis, Anastasios</au><au>Steinmann, Joerg</au><au>Rath, Peter-Michael</au><au>Mellies, Uwe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Upper airway microbial colonization in patients with neuromuscular disorders</atitle><jtitle>Respirology (Carlton, Vic.)</jtitle><addtitle>Respirology</addtitle><date>2016-10</date><risdate>2016</risdate><volume>21</volume><issue>7</issue><spage>1285</spage><epage>1291</epage><pages>1285-1291</pages><issn>1323-7799</issn><eissn>1440-1843</eissn><abstract>Background and objective
Inherited neuromuscular disorders (NMD) inevitably result in severe lung volume restriction and cough insufficiency associated with high morbidity and mortality. The aim of this retrospective study was to evaluate whether the airways of patients with NMD are colonized with potential pathogenic microorganisms that might contribute to the pulmonary morbidity in NMD.
Methods
In this cross‐sectional study, cough swabs were obtained and cultured for microbiological analyses from 77 patients with NMD and different degrees of lung volume restriction and cough insufficiency. Upper airway microbial colonization was compared to lung function parameters and cough peak flow values.
Results
Upper airway microbial colonization with potential pathogenic pathogens was identified in 39/77 (51%) of the subjects. Upper airway microbial colonization was associated with lower forced vital capacity (% pred.) 26.6 ± 19.7 versus 41.8 ± 20.4, P < 0.001 and cough peak flow (l/min) 125 ± 55 versus 207 ± 100, P < 0.001. In the subgroup colonized with potential pathogenic Gram‐negative bacteria or Staphylococcus aureus forced vital capacity and cough peak flow remained significantly lower compared with subjects without upper airway colonization (FVC (% pred.): 22.6 ± 16.5 vs 37.9 ± 21.5, P = 0.003; CPF (l/min): 123 ± 60 vs 179 ± 93, P = 0.013).
Conclusion
Severe respiratory compromise in patients with NMD is associated with upper airway microbial airway colonization, which might contribute to respiratory morbidity/insufficiency.
This retrospective data analysis shows for the first time that advanced stages of lung volume restriction and cough insufficiency in patients with neuromuscular disorders are accompanied by microbial airway colonization. Treatment of chronic bacterial colonization/infection may offer a new therapeutic strategy to reduce respiratory morbidity of patients with neuromuscular disorders.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>27221716</pmid><doi>10.1111/resp.12814</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Journals |
| subjects | Adolescent Adult airway colonization Child Cough - microbiology Cough - physiopathology cough insufficiency Cross-Sectional Studies Duchenne muscular dystrophy Female Humans lung function Lung Volume Measurements Male Neuromuscular Diseases - complications Neuromuscular Diseases - microbiology Neuromuscular Diseases - physiopathology neuromuscular disorders Respiratory Insufficiency - etiology Retrospective Studies Staphylococcus aureus Tidal Volume Young Adult |
| title | Upper airway microbial colonization in patients with neuromuscular disorders |
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