Subthalamic stimulation may inhibit the beneficial effects of levodopa on akinesia and gait

Background Gait and akinesia deterioration in PD patients during the immediate postoperative period of DBS has been directly related to stimulation in the subthalamic region. The underlying mechanisms remain poorly understood. The aim of the present study was to clinically and anatomically describe...

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Veröffentlicht in:	Movement disorders 2016-09, Vol.31 (9), p.1389-1397
Hauptverfasser:	Fleury, Vanessa, Pollak, Pierre, Gere, Julien, Tommasi, Giorgio, Romito, Luigi, Combescure, Christophe, Bardinet, Eric, Chabardes, Stephan, Momjian, Shahan, Krainik, Alexandre, Burkhard, Pierre, Yelnik, Jérôme, Krack, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Combined Modality Therapy Deep Brain Stimulation - adverse effects Dopamine Agents - administration & dosage Dopamine Agents - pharmacology Dyskinesias - etiology Female Gait Disorders, Neurologic - etiology Humans Levodopa - administration & dosage Levodopa - pharmacology Male Middle Aged Movement disorders Parkinson Disease - drug therapy Parkinson Disease - therapy Subthalamic Nucleus
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