Does bilateral seminal vesicle invasion at radical prostatectomy predict worse prognosis than unilateral invasion among patients with pT3b prostate cancers?
Objectives To determine whether bilateral seminal vesicle invasion is associated with worse biochemical recurrence‐free survival than unilateral seminal vesicle invasion after radical prostatectomy. Methods We reviewed the clinicopathological data of 598 men who underwent radical prostatectomy betwe...
Gespeichert in:
| Veröffentlicht in: | International journal of urology 2016-09, Vol.23 (9), p.758-763 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 763 |
|---|---|
| container_issue | 9 |
| container_start_page | 758 |
| container_title | International journal of urology |
| container_volume | 23 |
| creator | Lee, Hyun Jung Han, Jun-Hee Lee, Dong Hoon Nam, Jong Kil Kim, Tae Nam Chung, Moon Kee Park, Sung-Woo |
| description | Objectives
To determine whether bilateral seminal vesicle invasion is associated with worse biochemical recurrence‐free survival than unilateral seminal vesicle invasion after radical prostatectomy.
Methods
We reviewed the clinicopathological data of 598 men who underwent radical prostatectomy between 2008 and 2015. Among them, 107 (17.9%) had seminal vesicle invasion. After excluding cases with neo‐/adjuvant hormone treatment or radiotherapy, 93 were included in the analysis. We compared biochemical recurrence‐free survival rates in subgroups with or without bilateral seminal vesicle invasion using Kaplan–Meier estimates. Cox proportional hazard regression models were used to determine the predictors of biochemical recurrence‐free survival.
Results
Bilateral prostatic lobes and bilateral seminal vesicles were involved by prostate cancers in 85 (91.4%) and 35 patients (37.6%), respectively. Actuarial 3‐year and 5‐year biochemical recurrence‐free survival rates in patients with pT3b tumors with/without bilateral seminal vesicle invasion were 13.0%/34.3%, and 4.3%/19.8%, respectively. On multivariable analysis, preoperative prostate‐specific antigen (hazard ratio 1.01, 95% confidence interval 1.00–1.02, P = 0.034), lymph node metastasis (hazard ratio 2.88, 95% confidence interval 1.43–5.81, P = 0.003) and bilateral seminal vesicle invasion (hazard ratio 1.75, 95% confidence interval 1.01–3.05, P = 0.047) were independent predictors of biochemical recurrence‐free survival. After excluding cases with lymph node metastasis, preoperative prostate‐specific antigen, surgical margin status and bilateral seminal vesicle invasion were independent predictors of biochemical recurrence‐free survival.
Conclusions
Although most men with seminal vesicle invasion experience biochemical recurrences after radical prostatectomy, their survival outcome is not uniform. Bilateral seminal vesicle invasion seems to represent an independent prognostic factor for pT3b patients, together with the preoperative prostate‐specific antigen and lymph node status. |
| doi_str_mv | 10.1111/iju.13144 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1827903608</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1816631536</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4204-defd57101d39ed2c4151e6167ebc9d5b159c28f46bbc6c7b6c93cfa577e69a673</originalsourceid><addsrcrecordid>eNqNkcFu1DAQhi0EokvhwAsgH-GQ1o5jOzkhVKAtWhUhtQJxsRxn0rokztbjdNl34WFx2XY5IeGDLXu--eTRT8hLzg54Xof-ej7gglfVI7LIe1mUrCofkwVreFPUXJd75BniNWNclLx-SvZKLZislVyQX-8nQNr6wSaIdqAIow_5vAX0bgDqw61FPwVqE4228y7XVnHClHmXpnGTb5CfE11PEeGudhkm9EjTlQ10DjvzX9M4hUu6sslDSEjXPl3R1blod17qbHAQ8e1z8qS3A8KL-3OfXHz8cH50Uiw_H58evVsWrsqTFh30ndSc8U400JWu4pKD4kpD65pOtlw2rqz7SrWtU063yjXC9VZqDaqxSot98nrrzT-4mQGTGT06GAYbYJrR8LrUDROK1f-BcqUEl0Jl9M0WdXkujNCbVfSjjRvDmbnLzeTczJ_cMvvqXju3I3Q78iGoDBxugbUfYPNvkzn9dPGgLLYdHhP83HXY-MPkkbU0X8-OzYn88n159k0aKX4D7dq1MQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1816631536</pqid></control><display><type>article</type><title>Does bilateral seminal vesicle invasion at radical prostatectomy predict worse prognosis than unilateral invasion among patients with pT3b prostate cancers?</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Lee, Hyun Jung ; Han, Jun-Hee ; Lee, Dong Hoon ; Nam, Jong Kil ; Kim, Tae Nam ; Chung, Moon Kee ; Park, Sung-Woo</creator><creatorcontrib>Lee, Hyun Jung ; Han, Jun-Hee ; Lee, Dong Hoon ; Nam, Jong Kil ; Kim, Tae Nam ; Chung, Moon Kee ; Park, Sung-Woo</creatorcontrib><description>Objectives
To determine whether bilateral seminal vesicle invasion is associated with worse biochemical recurrence‐free survival than unilateral seminal vesicle invasion after radical prostatectomy.
Methods
We reviewed the clinicopathological data of 598 men who underwent radical prostatectomy between 2008 and 2015. Among them, 107 (17.9%) had seminal vesicle invasion. After excluding cases with neo‐/adjuvant hormone treatment or radiotherapy, 93 were included in the analysis. We compared biochemical recurrence‐free survival rates in subgroups with or without bilateral seminal vesicle invasion using Kaplan–Meier estimates. Cox proportional hazard regression models were used to determine the predictors of biochemical recurrence‐free survival.
Results
Bilateral prostatic lobes and bilateral seminal vesicles were involved by prostate cancers in 85 (91.4%) and 35 patients (37.6%), respectively. Actuarial 3‐year and 5‐year biochemical recurrence‐free survival rates in patients with pT3b tumors with/without bilateral seminal vesicle invasion were 13.0%/34.3%, and 4.3%/19.8%, respectively. On multivariable analysis, preoperative prostate‐specific antigen (hazard ratio 1.01, 95% confidence interval 1.00–1.02, P = 0.034), lymph node metastasis (hazard ratio 2.88, 95% confidence interval 1.43–5.81, P = 0.003) and bilateral seminal vesicle invasion (hazard ratio 1.75, 95% confidence interval 1.01–3.05, P = 0.047) were independent predictors of biochemical recurrence‐free survival. After excluding cases with lymph node metastasis, preoperative prostate‐specific antigen, surgical margin status and bilateral seminal vesicle invasion were independent predictors of biochemical recurrence‐free survival.
Conclusions
Although most men with seminal vesicle invasion experience biochemical recurrences after radical prostatectomy, their survival outcome is not uniform. Bilateral seminal vesicle invasion seems to represent an independent prognostic factor for pT3b patients, together with the preoperative prostate‐specific antigen and lymph node status.</description><identifier>ISSN: 0919-8172</identifier><identifier>EISSN: 1442-2042</identifier><identifier>DOI: 10.1111/iju.13144</identifier><identifier>PMID: 27305865</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>pathology ; prostate cancer ; prostatectomy ; seminal vesicle ; survival</subject><ispartof>International journal of urology, 2016-09, Vol.23 (9), p.758-763</ispartof><rights>2016 The Japanese Urological Association</rights><rights>2016 The Japanese Urological Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4204-defd57101d39ed2c4151e6167ebc9d5b159c28f46bbc6c7b6c93cfa577e69a673</citedby><cites>FETCH-LOGICAL-c4204-defd57101d39ed2c4151e6167ebc9d5b159c28f46bbc6c7b6c93cfa577e69a673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fiju.13144$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fiju.13144$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27305865$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Hyun Jung</creatorcontrib><creatorcontrib>Han, Jun-Hee</creatorcontrib><creatorcontrib>Lee, Dong Hoon</creatorcontrib><creatorcontrib>Nam, Jong Kil</creatorcontrib><creatorcontrib>Kim, Tae Nam</creatorcontrib><creatorcontrib>Chung, Moon Kee</creatorcontrib><creatorcontrib>Park, Sung-Woo</creatorcontrib><title>Does bilateral seminal vesicle invasion at radical prostatectomy predict worse prognosis than unilateral invasion among patients with pT3b prostate cancers?</title><title>International journal of urology</title><addtitle>Int. J. Urol</addtitle><description>Objectives
To determine whether bilateral seminal vesicle invasion is associated with worse biochemical recurrence‐free survival than unilateral seminal vesicle invasion after radical prostatectomy.
Methods
We reviewed the clinicopathological data of 598 men who underwent radical prostatectomy between 2008 and 2015. Among them, 107 (17.9%) had seminal vesicle invasion. After excluding cases with neo‐/adjuvant hormone treatment or radiotherapy, 93 were included in the analysis. We compared biochemical recurrence‐free survival rates in subgroups with or without bilateral seminal vesicle invasion using Kaplan–Meier estimates. Cox proportional hazard regression models were used to determine the predictors of biochemical recurrence‐free survival.
Results
Bilateral prostatic lobes and bilateral seminal vesicles were involved by prostate cancers in 85 (91.4%) and 35 patients (37.6%), respectively. Actuarial 3‐year and 5‐year biochemical recurrence‐free survival rates in patients with pT3b tumors with/without bilateral seminal vesicle invasion were 13.0%/34.3%, and 4.3%/19.8%, respectively. On multivariable analysis, preoperative prostate‐specific antigen (hazard ratio 1.01, 95% confidence interval 1.00–1.02, P = 0.034), lymph node metastasis (hazard ratio 2.88, 95% confidence interval 1.43–5.81, P = 0.003) and bilateral seminal vesicle invasion (hazard ratio 1.75, 95% confidence interval 1.01–3.05, P = 0.047) were independent predictors of biochemical recurrence‐free survival. After excluding cases with lymph node metastasis, preoperative prostate‐specific antigen, surgical margin status and bilateral seminal vesicle invasion were independent predictors of biochemical recurrence‐free survival.
Conclusions
Although most men with seminal vesicle invasion experience biochemical recurrences after radical prostatectomy, their survival outcome is not uniform. Bilateral seminal vesicle invasion seems to represent an independent prognostic factor for pT3b patients, together with the preoperative prostate‐specific antigen and lymph node status.</description><subject>pathology</subject><subject>prostate cancer</subject><subject>prostatectomy</subject><subject>seminal vesicle</subject><subject>survival</subject><issn>0919-8172</issn><issn>1442-2042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkcFu1DAQhi0EokvhwAsgH-GQ1o5jOzkhVKAtWhUhtQJxsRxn0rokztbjdNl34WFx2XY5IeGDLXu--eTRT8hLzg54Xof-ej7gglfVI7LIe1mUrCofkwVreFPUXJd75BniNWNclLx-SvZKLZislVyQX-8nQNr6wSaIdqAIow_5vAX0bgDqw61FPwVqE4228y7XVnHClHmXpnGTb5CfE11PEeGudhkm9EjTlQ10DjvzX9M4hUu6sslDSEjXPl3R1blod17qbHAQ8e1z8qS3A8KL-3OfXHz8cH50Uiw_H58evVsWrsqTFh30ndSc8U400JWu4pKD4kpD65pOtlw2rqz7SrWtU063yjXC9VZqDaqxSot98nrrzT-4mQGTGT06GAYbYJrR8LrUDROK1f-BcqUEl0Jl9M0WdXkujNCbVfSjjRvDmbnLzeTczJ_cMvvqXju3I3Q78iGoDBxugbUfYPNvkzn9dPGgLLYdHhP83HXY-MPkkbU0X8-OzYn88n159k0aKX4D7dq1MQ</recordid><startdate>201609</startdate><enddate>201609</enddate><creator>Lee, Hyun Jung</creator><creator>Han, Jun-Hee</creator><creator>Lee, Dong Hoon</creator><creator>Nam, Jong Kil</creator><creator>Kim, Tae Nam</creator><creator>Chung, Moon Kee</creator><creator>Park, Sung-Woo</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>201609</creationdate><title>Does bilateral seminal vesicle invasion at radical prostatectomy predict worse prognosis than unilateral invasion among patients with pT3b prostate cancers?</title><author>Lee, Hyun Jung ; Han, Jun-Hee ; Lee, Dong Hoon ; Nam, Jong Kil ; Kim, Tae Nam ; Chung, Moon Kee ; Park, Sung-Woo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4204-defd57101d39ed2c4151e6167ebc9d5b159c28f46bbc6c7b6c93cfa577e69a673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>pathology</topic><topic>prostate cancer</topic><topic>prostatectomy</topic><topic>seminal vesicle</topic><topic>survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Hyun Jung</creatorcontrib><creatorcontrib>Han, Jun-Hee</creatorcontrib><creatorcontrib>Lee, Dong Hoon</creatorcontrib><creatorcontrib>Nam, Jong Kil</creatorcontrib><creatorcontrib>Kim, Tae Nam</creatorcontrib><creatorcontrib>Chung, Moon Kee</creatorcontrib><creatorcontrib>Park, Sung-Woo</creatorcontrib><collection>Istex</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>International journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Hyun Jung</au><au>Han, Jun-Hee</au><au>Lee, Dong Hoon</au><au>Nam, Jong Kil</au><au>Kim, Tae Nam</au><au>Chung, Moon Kee</au><au>Park, Sung-Woo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does bilateral seminal vesicle invasion at radical prostatectomy predict worse prognosis than unilateral invasion among patients with pT3b prostate cancers?</atitle><jtitle>International journal of urology</jtitle><addtitle>Int. J. Urol</addtitle><date>2016-09</date><risdate>2016</risdate><volume>23</volume><issue>9</issue><spage>758</spage><epage>763</epage><pages>758-763</pages><issn>0919-8172</issn><eissn>1442-2042</eissn><abstract>Objectives
To determine whether bilateral seminal vesicle invasion is associated with worse biochemical recurrence‐free survival than unilateral seminal vesicle invasion after radical prostatectomy.
Methods
We reviewed the clinicopathological data of 598 men who underwent radical prostatectomy between 2008 and 2015. Among them, 107 (17.9%) had seminal vesicle invasion. After excluding cases with neo‐/adjuvant hormone treatment or radiotherapy, 93 were included in the analysis. We compared biochemical recurrence‐free survival rates in subgroups with or without bilateral seminal vesicle invasion using Kaplan–Meier estimates. Cox proportional hazard regression models were used to determine the predictors of biochemical recurrence‐free survival.
Results
Bilateral prostatic lobes and bilateral seminal vesicles were involved by prostate cancers in 85 (91.4%) and 35 patients (37.6%), respectively. Actuarial 3‐year and 5‐year biochemical recurrence‐free survival rates in patients with pT3b tumors with/without bilateral seminal vesicle invasion were 13.0%/34.3%, and 4.3%/19.8%, respectively. On multivariable analysis, preoperative prostate‐specific antigen (hazard ratio 1.01, 95% confidence interval 1.00–1.02, P = 0.034), lymph node metastasis (hazard ratio 2.88, 95% confidence interval 1.43–5.81, P = 0.003) and bilateral seminal vesicle invasion (hazard ratio 1.75, 95% confidence interval 1.01–3.05, P = 0.047) were independent predictors of biochemical recurrence‐free survival. After excluding cases with lymph node metastasis, preoperative prostate‐specific antigen, surgical margin status and bilateral seminal vesicle invasion were independent predictors of biochemical recurrence‐free survival.
Conclusions
Although most men with seminal vesicle invasion experience biochemical recurrences after radical prostatectomy, their survival outcome is not uniform. Bilateral seminal vesicle invasion seems to represent an independent prognostic factor for pT3b patients, together with the preoperative prostate‐specific antigen and lymph node status.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>27305865</pmid><doi>10.1111/iju.13144</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0919-8172 |
| ispartof | International journal of urology, 2016-09, Vol.23 (9), p.758-763 |
| issn | 0919-8172 1442-2042 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1827903608 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | pathology prostate cancer prostatectomy seminal vesicle survival |
| title | Does bilateral seminal vesicle invasion at radical prostatectomy predict worse prognosis than unilateral invasion among patients with pT3b prostate cancers? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T23%3A31%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Does%20bilateral%20seminal%20vesicle%20invasion%20at%20radical%20prostatectomy%20predict%20worse%20prognosis%20than%20unilateral%20invasion%20among%20patients%20with%20pT3b%20prostate%20cancers?&rft.jtitle=International%20journal%20of%20urology&rft.au=Lee,%20Hyun%20Jung&rft.date=2016-09&rft.volume=23&rft.issue=9&rft.spage=758&rft.epage=763&rft.pages=758-763&rft.issn=0919-8172&rft.eissn=1442-2042&rft_id=info:doi/10.1111/iju.13144&rft_dat=%3Cproquest_cross%3E1816631536%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1816631536&rft_id=info:pmid/27305865&rfr_iscdi=true |