Genotyping NUDT15 can predict the dose reduction of 6-MP for children with acute lymphoblastic leukemia especially at a preschool age

The pharmacokinetics among children has been altered dynamically. The difference between children and adults is caused by immaturity in things such as metabolic enzymes and transport proteins. The periods when these alterations happen vary from a few days to some years after birth. We hypothesized t...

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Veröffentlicht in:	Journal of human genetics 2016-09, Vol.61 (9), p.797-801
Hauptverfasser:	Suzuki, Hisato, Fukushima, Hiroko, Suzuki, Ryoko, Hosaka, Sho, Yamaki, Yuni, Kobayashi, Chie, Sakai, Aiko, Imagawa, Kazuo, Iwabuchi, Atsushi, Yoshimi, Ai, Nakao, Tomohei, Kato, Keisuke, Tsuchida, Masahiro, Kiyokawa, Nobutaka, Koike, Kazutoshi, Noguchi, Emiko, Fukushima, Takashi, Sumazaki, Ryo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age Factors Alleles Antimetabolites, Antineoplastic - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Child Child, Preschool Female Gene Frequency Genetic Association Studies Genotype Humans Infant Male Mercaptopurine - administration & dosage Methyltransferases - genetics Pharmacogenetics Polymorphism, Genetic Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Pyrophosphatases - genetics
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