The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I–peptide complex formation

CD8α + DCs are specialized at cross-presentation, but the mechanisms that bestow this ability have not been fully characterized. Cao and colleagues show that the lectin Siglec-G negatively regulates cross-presentation and that its expression is lower in CD8α + DCs. CD8α + dendritic cells (DCs) are s...

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Veröffentlicht in:	Nature immunology 2016-10, Vol.17 (10), p.1167-1175
Hauptverfasser:	Ding, Yuanyuan, Guo, Zhenhong, Liu, Yiqi, Li, Xia, Zhang, Qian, Xu, Xiongfei, Gu, Yan, Zhang, Yi, Zhao, Dezhi, Cao, Xuetao
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 631/250/21/1293 631/250/2152/1566/20 96/95 Animals Antigens - metabolism Bacterial diseases Biomedicine CD8 Antigens - metabolism Cross-Priming Dendritic Cells - immunology Gene expression Genetic aspects Health aspects Histocompatibility Antigens Class I - metabolism Immune response Immunology Infectious Diseases Lectins Lectins - genetics Lectins - metabolism Listeria monocytogenes - immunology Listeriosis - immunology Lymphocyte Activation Lymphocytes Major histocompatibility complex Melanoma, Experimental Mice Mice, Inbred C57BL Mice, Knockout NADPH Oxidases - metabolism Neoplasms, Experimental - immunology Peptide Fragments - metabolism Phagocytosis - genetics Properties Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism Receptors, Antigen, B-Cell - genetics Receptors, Antigen, B-Cell - metabolism Signal Transduction T-Lymphocytes, Cytotoxic - immunology Tumor Burden - genetics
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