CD1a on Langerhans cells controls inflammatory skin disease

Human Langerhans cells express CD1a, but those in mice do not, which makes determination of its function on these cells challenging in vivo . Through the use of a transgenic mouse that expresses CD1a, Winau and colleagues demonstrate that Langerhans cells use CD1a to present contact allergens and se...

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Veröffentlicht in:	Nature immunology 2016-10, Vol.17 (10), p.1159-1166
Hauptverfasser:	Kim, Ji Hyung, Hu, Yu, Yongqing, Tang, Kim, Jessica, Hughes, Victoria A, Le Nours, Jérôme, Marquez, Elsa A, Purcell, Anthony W, Wan, Qi, Sugita, Masahiko, Rossjohn, Jamie, Winau, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/31 14/19 631/250/21/1566 631/250/249/2510/1758 631/250/251/1574 631/250/38 64/60 82/16 82/58 82/83 Allergens Animals Antibodies, Blocking - administration & dosage Antigens Antigens, CD1 - genetics Antigens, CD1 - immunology Antigens, CD1 - metabolism Autoantigens Autoantigens - metabolism Biomedicine Blocking antibodies Catechols - chemistry Catechols - metabolism CD4 antigen Congeners Crystal structure Crystallography, X-Ray Dermatitis Dermatitis, Toxicodendron - immunology Development and progression Disease Models, Animal Genetic aspects Helper cells Humans Immunology Infectious Diseases Inflammation Interleukin 17 Interleukin 22 Interleukin-17 - metabolism Interleukins - metabolism Langerhans cells Langerhans Cells - immunology Lipids Lymphocytes T Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Physiological aspects Plants Protein Conformation Psoriasis Psoriasis - immunology Skin diseases Th17 Cells - immunology Therapeutic targets Toxicodendron - immunology Transgenic mice
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