Glioma-secreted soluble factors stimulate microglial activation: The role of interleukin-1β and tumor necrosis factor-α

Abstract We aimed to elucidate the effect of soluble factors secreted by glioma on microglial activation. Conditioned medium (CM) from glioma cells, CRT-MG and C6, significantly induced nitric oxide (NO) production and stimulated the mRNA expression of inducible NO synthase (iNOS), interleukin (IL)-...

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Veröffentlicht in:	Journal of neuroimmunology 2016-09, Vol.298, p.165-171
Hauptverfasser:	Hwang, Ji-Sun, Jung, Eun-Hye, Kwon, Mi-Youn, Han, Inn-Oc
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Animals, Newborn Antibodies - pharmacology Cell Line, Tumor Cells, Cultured Culture Media, Conditioned - chemistry Culture Media, Conditioned - pharmacology Cyclooxygenase 2 - metabolism Enzyme Inhibitors - pharmacology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Glioma Glioma - chemistry Glioma - pathology Glioma - secretion Humans Imidazoles - pharmacology Infant, Newborn Interleukin-1beta Interleukin-1beta - genetics Interleukin-1beta - immunology Interleukin-1beta - metabolism Mice Microglia Microglia - drug effects Neurology Nitrites - metabolism p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Pyridines - pharmacology Rats Rats, Sprague-Dawley Tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism
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