The synthetic ajoene analog SPA3015 induces apoptotic cell death through crosstalk between NF-κB and PPARγ in multidrug-resistant cancer cells

Multidrug resistance (MDR) caused by P-glycoprotein (P-gp) overexpression impedes successful cancer chemotherapy. In this study, we investigated the anticancer effects of SPA3015, a synthetic ajoene analog, in P-gp-overexpressing MDR cancer cells (KBV20C and MES-SA/DX5). Treatment with SPA3015 cause...

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Veröffentlicht in:	Food and chemical toxicology 2016-10, Vol.96, p.35-42
Hauptverfasser:	Hwang, Jee Won, Cho, Hyewon, Lee, Jae Yeon, Jeon, Youngsic, Kim, Su-Nam, Lee, Sang Jin, Bae, Gyu-Un, Yoon, Sungpil, Jeon, Raok, Kim, Yong Kee
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Blotting, Western Cell Cycle - drug effects Cell Nucleus - drug effects Cell Nucleus - metabolism Cell Proliferation - drug effects Disulfides - chemistry Disulfides - pharmacology Drug Resistance, Multiple - drug effects Drug Resistance, Neoplasm - drug effects Gene Expression Regulation, Neoplastic - drug effects Humans Immunoprecipitation Multidrug resistance Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology NF-kappa B - genetics NF-kappa B - metabolism NF-κB Platelet Aggregation Inhibitors - chemistry Platelet Aggregation Inhibitors - pharmacology PPAR gamma - genetics PPAR gamma - metabolism PPARγ Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics SPA3015 Tumor Cells, Cultured
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