Systematic Review of Adverse Effects from Herbal Drugs Reported in Randomized Controlled Trials
Herbal drugs have become a popular form of healthcare, raising concerns about their safety. This study aimed to characterize the adverse effects of herbal drugs through a systematic review of results reported in randomized controlled trials (RCTs). Using eight electronic databases including PubMed,...
Gespeichert in:
| Veröffentlicht in: | Phytotherapy research 2016-09, Vol.30 (9), p.1412-1419 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1419 |
|---|---|
| container_issue | 9 |
| container_start_page | 1412 |
| container_title | Phytotherapy research |
| container_volume | 30 |
| creator | Lee, Ji Young Jun, Seung Ah Hong, Sung Shin Ahn, Yo Chan Lee, Dong Soo Son, Chang Gue |
| description | Herbal drugs have become a popular form of healthcare, raising concerns about their safety. This study aimed to characterize the adverse effects of herbal drugs through a systematic review of results reported in randomized controlled trials (RCTs). Using eight electronic databases including PubMed, the Cochrane library and six Korean medical databases, the frequency of reported toxicity was recorded based on drug composition and indication. Among 4957 potentially relevant articles, 242 papers comprised of 244 studies met our inclusion criteria; these included 111 studies of a single herb and 133 of multiple herbs. These studies accounted for a total 15 441 participants (male = 5590; female = 9851; 7383 for single and 8058 for multiple herb studies). There were 480 cases (3.1%) of adverse events (344 for single, 136 for multiple herb studies; p |
| doi_str_mv | 10.1002/ptr.5647 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1827899713</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1817050285</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3877-ca21e6d301ca92977dd6bfbd4570509aa118969ac25861e722ae0a6c520c59353</originalsourceid><addsrcrecordid>eNqN0ctu1DAUBmALgehQkHgCZIkNm7S2E9-W1dCb1NJRGC47y-OcIJckHuykZXj6OmppJVasji1_Osf2j9BbSg4oIexwO8YDLir5DC0o0bqgXJbP0YJoTouKqu976FVK14QQzUj1Eu0xSbXQSi2Q-bxLI_R29A7XcOPhFocWHzU3EBPg47YFNybcxtDjM4gb2-GPcfqRst2GOEKD_YBrOzSh93_ybhmGMYauy8t19LZLr9GLNhd481D30ZeT4_XyrLi4Oj1fHl0UrlRSFs4yCqIpCXVWMy1l04hNu2kqLgkn2lpKVb6xdYwrQUEyZoFY4TgjjuuSl_vow33fbQy_Jkij6X1y0HV2gDAlQxWTSmtJy_-gdB7K1Nz1_T_0OkxxyA-ZlVCylJXI6t2DmjY9NGYbfW_jzvz95QyKe3DrO9g9nlNi5vRMTs_M6ZnVup7rk_c5m9-P3safRuSR3Hz7dGpq_XW5qlcn5rK8A3BGmdc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1816873746</pqid></control><display><type>article</type><title>Systematic Review of Adverse Effects from Herbal Drugs Reported in Randomized Controlled Trials</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Lee, Ji Young ; Jun, Seung Ah ; Hong, Sung Shin ; Ahn, Yo Chan ; Lee, Dong Soo ; Son, Chang Gue</creator><creatorcontrib>Lee, Ji Young ; Jun, Seung Ah ; Hong, Sung Shin ; Ahn, Yo Chan ; Lee, Dong Soo ; Son, Chang Gue</creatorcontrib><description>Herbal drugs have become a popular form of healthcare, raising concerns about their safety. This study aimed to characterize the adverse effects of herbal drugs through a systematic review of results reported in randomized controlled trials (RCTs). Using eight electronic databases including PubMed, the Cochrane library and six Korean medical databases, the frequency of reported toxicity was recorded based on drug composition and indication. Among 4957 potentially relevant articles, 242 papers comprised of 244 studies met our inclusion criteria; these included 111 studies of a single herb and 133 of multiple herbs. These studies accounted for a total 15 441 participants (male = 5590; female = 9851; 7383 for single and 8058 for multiple herb studies). There were 480 cases (3.1%) of adverse events (344 for single, 136 for multiple herb studies; p < 0.01). A total of 259 cases reported blood test abnormalities, including five cases of abnormality in hepatic functional enzymes. The most frequently reported adverse event was digestive symptoms (44.3%), followed by nervous system symptoms (17.3%) and behaviors such as loss of appetite (16.3%). This is the first systematic review of adverse effects of herbal drugs among clinical studies, and the results indicate that herbal drugs are relatively safe. Copyright © 2016 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.5647</identifier><identifier>PMID: 27196988</identifier><identifier>CODEN: PHYREH</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; adverse drug reaction ; adverse effect ; Drug-Related Side Effects and Adverse Reactions ; Drugs, Chinese Herbal - adverse effects ; Drugs, Chinese Herbal - therapeutic use ; Female ; herbal drug ; herbal medicine ; Humans ; Male ; Randomized Controlled Trials as Topic</subject><ispartof>Phytotherapy research, 2016-09, Vol.30 (9), p.1412-1419</ispartof><rights>Copyright © 2016 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3877-ca21e6d301ca92977dd6bfbd4570509aa118969ac25861e722ae0a6c520c59353</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.5647$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.5647$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27196988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Ji Young</creatorcontrib><creatorcontrib>Jun, Seung Ah</creatorcontrib><creatorcontrib>Hong, Sung Shin</creatorcontrib><creatorcontrib>Ahn, Yo Chan</creatorcontrib><creatorcontrib>Lee, Dong Soo</creatorcontrib><creatorcontrib>Son, Chang Gue</creatorcontrib><title>Systematic Review of Adverse Effects from Herbal Drugs Reported in Randomized Controlled Trials</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>Herbal drugs have become a popular form of healthcare, raising concerns about their safety. This study aimed to characterize the adverse effects of herbal drugs through a systematic review of results reported in randomized controlled trials (RCTs). Using eight electronic databases including PubMed, the Cochrane library and six Korean medical databases, the frequency of reported toxicity was recorded based on drug composition and indication. Among 4957 potentially relevant articles, 242 papers comprised of 244 studies met our inclusion criteria; these included 111 studies of a single herb and 133 of multiple herbs. These studies accounted for a total 15 441 participants (male = 5590; female = 9851; 7383 for single and 8058 for multiple herb studies). There were 480 cases (3.1%) of adverse events (344 for single, 136 for multiple herb studies; p < 0.01). A total of 259 cases reported blood test abnormalities, including five cases of abnormality in hepatic functional enzymes. The most frequently reported adverse event was digestive symptoms (44.3%), followed by nervous system symptoms (17.3%) and behaviors such as loss of appetite (16.3%). This is the first systematic review of adverse effects of herbal drugs among clinical studies, and the results indicate that herbal drugs are relatively safe. Copyright © 2016 John Wiley & Sons, Ltd.</description><subject>Adult</subject><subject>adverse drug reaction</subject><subject>adverse effect</subject><subject>Drug-Related Side Effects and Adverse Reactions</subject><subject>Drugs, Chinese Herbal - adverse effects</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Female</subject><subject>herbal drug</subject><subject>herbal medicine</subject><subject>Humans</subject><subject>Male</subject><subject>Randomized Controlled Trials as Topic</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0ctu1DAUBmALgehQkHgCZIkNm7S2E9-W1dCb1NJRGC47y-OcIJckHuykZXj6OmppJVasji1_Osf2j9BbSg4oIexwO8YDLir5DC0o0bqgXJbP0YJoTouKqu976FVK14QQzUj1Eu0xSbXQSi2Q-bxLI_R29A7XcOPhFocWHzU3EBPg47YFNybcxtDjM4gb2-GPcfqRst2GOEKD_YBrOzSh93_ybhmGMYauy8t19LZLr9GLNhd481D30ZeT4_XyrLi4Oj1fHl0UrlRSFs4yCqIpCXVWMy1l04hNu2kqLgkn2lpKVb6xdYwrQUEyZoFY4TgjjuuSl_vow33fbQy_Jkij6X1y0HV2gDAlQxWTSmtJy_-gdB7K1Nz1_T_0OkxxyA-ZlVCylJXI6t2DmjY9NGYbfW_jzvz95QyKe3DrO9g9nlNi5vRMTs_M6ZnVup7rk_c5m9-P3safRuSR3Hz7dGpq_XW5qlcn5rK8A3BGmdc</recordid><startdate>201609</startdate><enddate>201609</enddate><creator>Lee, Ji Young</creator><creator>Jun, Seung Ah</creator><creator>Hong, Sung Shin</creator><creator>Ahn, Yo Chan</creator><creator>Lee, Dong Soo</creator><creator>Son, Chang Gue</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201609</creationdate><title>Systematic Review of Adverse Effects from Herbal Drugs Reported in Randomized Controlled Trials</title><author>Lee, Ji Young ; Jun, Seung Ah ; Hong, Sung Shin ; Ahn, Yo Chan ; Lee, Dong Soo ; Son, Chang Gue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3877-ca21e6d301ca92977dd6bfbd4570509aa118969ac25861e722ae0a6c520c59353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>adverse drug reaction</topic><topic>adverse effect</topic><topic>Drug-Related Side Effects and Adverse Reactions</topic><topic>Drugs, Chinese Herbal - adverse effects</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>Female</topic><topic>herbal drug</topic><topic>herbal medicine</topic><topic>Humans</topic><topic>Male</topic><topic>Randomized Controlled Trials as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Ji Young</creatorcontrib><creatorcontrib>Jun, Seung Ah</creatorcontrib><creatorcontrib>Hong, Sung Shin</creatorcontrib><creatorcontrib>Ahn, Yo Chan</creatorcontrib><creatorcontrib>Lee, Dong Soo</creatorcontrib><creatorcontrib>Son, Chang Gue</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Ji Young</au><au>Jun, Seung Ah</au><au>Hong, Sung Shin</au><au>Ahn, Yo Chan</au><au>Lee, Dong Soo</au><au>Son, Chang Gue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systematic Review of Adverse Effects from Herbal Drugs Reported in Randomized Controlled Trials</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2016-09</date><risdate>2016</risdate><volume>30</volume><issue>9</issue><spage>1412</spage><epage>1419</epage><pages>1412-1419</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><coden>PHYREH</coden><abstract>Herbal drugs have become a popular form of healthcare, raising concerns about their safety. This study aimed to characterize the adverse effects of herbal drugs through a systematic review of results reported in randomized controlled trials (RCTs). Using eight electronic databases including PubMed, the Cochrane library and six Korean medical databases, the frequency of reported toxicity was recorded based on drug composition and indication. Among 4957 potentially relevant articles, 242 papers comprised of 244 studies met our inclusion criteria; these included 111 studies of a single herb and 133 of multiple herbs. These studies accounted for a total 15 441 participants (male = 5590; female = 9851; 7383 for single and 8058 for multiple herb studies). There were 480 cases (3.1%) of adverse events (344 for single, 136 for multiple herb studies; p < 0.01). A total of 259 cases reported blood test abnormalities, including five cases of abnormality in hepatic functional enzymes. The most frequently reported adverse event was digestive symptoms (44.3%), followed by nervous system symptoms (17.3%) and behaviors such as loss of appetite (16.3%). This is the first systematic review of adverse effects of herbal drugs among clinical studies, and the results indicate that herbal drugs are relatively safe. Copyright © 2016 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>27196988</pmid><doi>10.1002/ptr.5647</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0951-418X |
| ispartof | Phytotherapy research, 2016-09, Vol.30 (9), p.1412-1419 |
| issn | 0951-418X 1099-1573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1827899713 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult adverse drug reaction adverse effect Drug-Related Side Effects and Adverse Reactions Drugs, Chinese Herbal - adverse effects Drugs, Chinese Herbal - therapeutic use Female herbal drug herbal medicine Humans Male Randomized Controlled Trials as Topic |
| title | Systematic Review of Adverse Effects from Herbal Drugs Reported in Randomized Controlled Trials |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T02%3A30%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Systematic%20Review%20of%20Adverse%20Effects%20from%20Herbal%20Drugs%20Reported%20in%20Randomized%20Controlled%20Trials&rft.jtitle=Phytotherapy%20research&rft.au=Lee,%20Ji%20Young&rft.date=2016-09&rft.volume=30&rft.issue=9&rft.spage=1412&rft.epage=1419&rft.pages=1412-1419&rft.issn=0951-418X&rft.eissn=1099-1573&rft.coden=PHYREH&rft_id=info:doi/10.1002/ptr.5647&rft_dat=%3Cproquest_pubme%3E1817050285%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1816873746&rft_id=info:pmid/27196988&rfr_iscdi=true |