Validation of a panel of ADAMTS13 assays for diagnosis of thrombotic thrombocytopenic purpura: activity, functional inhibitor, and autoantibody test

Summary Introduction Quantitation of ADAMTS13 activity, functional inhibitors, and autoantibodies is crucial in diagnosis and management of thrombotic thrombocytopenic purpura. We compared and optimized commercial assay kits and validated a testing panel. Methods Citrated plasma specimens from healt...

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Veröffentlicht in:	International journal of laboratory hematology 2016-10, Vol.38 (5), p.550-559
Hauptverfasser:	Nakashima, M. O., Zhang, X., Rogers, H. J., Vengal, L., Gibson Jr, B., Daly, T. M., Kottke-Marchant, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAMTS13 ADAMTS13 Protein - antagonists & inhibitors Adolescent Adult Aged Autoantibodies - blood Female Humans Male Middle Aged Protease Inhibitors - blood Purpura, Thrombotic Thrombocytopenic - blood Purpura, Thrombotic Thrombocytopenic - diagnosis Reagent Kits, Diagnostic thrombotic thrombocytopenic purpura TTP
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