Quantitative analysis of short- and long-distance racing performance in young and adult horses and association analysis with functional candidate genes in Spanish Trotter horses
Summary The association of five candidate genes with sporting performance in young and adult Spanish Trotter horses (STHs) was performed according to a previous selection based on quantitative analysis of the trait time per kilometre (TPK). A total of 334 516 records of TPK from 5958 STHs were used...
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| Veröffentlicht in: | Journal of animal breeding and genetics (1986) 2016-10, Vol.133 (5), p.347-356 |
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| container_title | Journal of animal breeding and genetics (1986) |
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| creator | Negro Rama, S. Valera, M. Membrillo, A. Gómez, M.D. Solé, M. Menendez-Buxadera, A. Anaya, G. Molina, A. |
| description | Summary
The association of five candidate genes with sporting performance in young and adult Spanish Trotter horses (STHs) was performed according to a previous selection based on quantitative analysis of the trait time per kilometre (TPK). A total of 334 516 records of TPK from 5958 STHs were used to estimate the estimated breeding values (EBVs) at different age groups (young and adults horses) throughout the range of distances (1600–2700 m) using a bicharacter random regression model. The heritability estimated by distance ranged from 0.16 to 0.40, with a different range for the two age groups. Considering the animals with the best and the worst deregressed EBV, 321 STHs were selected for SNP genotyping in MSTN, COX4I2, PDK4, DMRT3 and CKM genes. An association analysis based on ridge and logistic regression revealed that the young trotters with genotype GG in PDK4 (p |
| doi_str_mv | 10.1111/jbg.12208 |
| format | Article |
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The association of five candidate genes with sporting performance in young and adult Spanish Trotter horses (STHs) was performed according to a previous selection based on quantitative analysis of the trait time per kilometre (TPK). A total of 334 516 records of TPK from 5958 STHs were used to estimate the estimated breeding values (EBVs) at different age groups (young and adults horses) throughout the range of distances (1600–2700 m) using a bicharacter random regression model. The heritability estimated by distance ranged from 0.16 to 0.40, with a different range for the two age groups. Considering the animals with the best and the worst deregressed EBV, 321 STHs were selected for SNP genotyping in MSTN, COX4I2, PDK4, DMRT3 and CKM genes. An association analysis based on ridge and logistic regression revealed that the young trotters with genotype GG in PDK4 (p < 0.05) and AA of DMRT3 (p < 0.001) SNPs show the best potential in short‐distance races, while those carrying the genotype AA in DMRT3 (p < 0.001) and CC in CKM (p < 0.05) genes seem to be the best in long‐distance races. Adult trotters with genotype AA in DMRT3 also display greater speed (p < 0.05) and endurance (p < 0.001).]]></description><identifier>ISSN: 0931-2668</identifier><identifier>EISSN: 1439-0388</identifier><identifier>DOI: 10.1111/jbg.12208</identifier><identifier>PMID: 26991374</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Animals ; Breeding ; Breeding of animals ; Deregression ; endurance ability ; equine ; expected breeding value ; Female ; Genetic Association Studies ; Genotype & phenotype ; Horse racing ; Horses ; Horses - classification ; Horses - genetics ; Horses - physiology ; Male ; Physical Conditioning, Animal ; Polymorphism, Single Nucleotide ; Population genetics ; SNP ; sprinting ability</subject><ispartof>Journal of animal breeding and genetics (1986), 2016-10, Vol.133 (5), p.347-356</ispartof><rights>2016 Blackwell Verlag GmbH</rights><rights>2016 Blackwell Verlag GmbH.</rights><rights>Copyright © 2016 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4948-496f8a7e6476fa18be1ef372d99180f357150a03fde7a6753afd8ed34c2545e03</citedby><cites>FETCH-LOGICAL-c4948-496f8a7e6476fa18be1ef372d99180f357150a03fde7a6753afd8ed34c2545e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjbg.12208$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjbg.12208$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1413,27906,27907,45556,45557</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26991374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Negro Rama, S.</creatorcontrib><creatorcontrib>Valera, M.</creatorcontrib><creatorcontrib>Membrillo, A.</creatorcontrib><creatorcontrib>Gómez, M.D.</creatorcontrib><creatorcontrib>Solé, M.</creatorcontrib><creatorcontrib>Menendez-Buxadera, A.</creatorcontrib><creatorcontrib>Anaya, G.</creatorcontrib><creatorcontrib>Molina, A.</creatorcontrib><title>Quantitative analysis of short- and long-distance racing performance in young and adult horses and association analysis with functional candidate genes in Spanish Trotter horses</title><title>Journal of animal breeding and genetics (1986)</title><addtitle>J. Anim. Breed. Genet</addtitle><description><![CDATA[Summary
The association of five candidate genes with sporting performance in young and adult Spanish Trotter horses (STHs) was performed according to a previous selection based on quantitative analysis of the trait time per kilometre (TPK). A total of 334 516 records of TPK from 5958 STHs were used to estimate the estimated breeding values (EBVs) at different age groups (young and adults horses) throughout the range of distances (1600–2700 m) using a bicharacter random regression model. The heritability estimated by distance ranged from 0.16 to 0.40, with a different range for the two age groups. Considering the animals with the best and the worst deregressed EBV, 321 STHs were selected for SNP genotyping in MSTN, COX4I2, PDK4, DMRT3 and CKM genes. An association analysis based on ridge and logistic regression revealed that the young trotters with genotype GG in PDK4 (p < 0.05) and AA of DMRT3 (p < 0.001) SNPs show the best potential in short‐distance races, while those carrying the genotype AA in DMRT3 (p < 0.001) and CC in CKM (p < 0.05) genes seem to be the best in long‐distance races. Adult trotters with genotype AA in DMRT3 also display greater speed (p < 0.05) and endurance (p < 0.001).]]></description><subject>Animals</subject><subject>Breeding</subject><subject>Breeding of animals</subject><subject>Deregression</subject><subject>endurance ability</subject><subject>equine</subject><subject>expected breeding value</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Genotype & phenotype</subject><subject>Horse racing</subject><subject>Horses</subject><subject>Horses - classification</subject><subject>Horses - genetics</subject><subject>Horses - physiology</subject><subject>Male</subject><subject>Physical Conditioning, Animal</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population genetics</subject><subject>SNP</subject><subject>sprinting ability</subject><issn>0931-2668</issn><issn>1439-0388</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkVGLEzEUhYMobrf64B-QgC_6MLvJZCbJPOqirboo4oq-hXTmpk2dJjXJ7Nqf5T807XRXEAQDIXD4zrncHISeUHJG8zlfL5ZntCyJvIcmtGJNQZiU99GENIwWJefyBJ3GuCYk66J5iE5K3jSUiWqCfn0atEs26WSvAWun-120EXuD48qHVGSpw713y6KzMWnXAg66tW6JtxCMD5uDZB3e-SGLe1p3Q59wdkeIoxCjb22e4N2fCTc2rbAZXLuXdY_bTNpOJ8BLcNmYIz9vtbNxha-CTwnCMfIRemB0H-Hx8Z2iL29eX13Mi8uPs7cXLy-LtmoqWVQNN1IL4JXgRlO5AAqGibLLm0tiWC1oTTRhpgOhuaiZNp2EjlVtWVc1EDZFz8fcbfA_BohJbWxsoe-1Az9ERWUpZMNlSf8DpQ0t860z-uwvdO2HkD_gQElWSZ5bm6IXI9UGH2MAo7bBbnTYKUrUvnKVK1eHyjP79Jg4LDbQ3ZG3HWfgfARubA-7fyepd69mt5HF6MiVw887hw7fFRdM1Orrh5maV-9r8Y3NFWe_AZPPxyc</recordid><startdate>201610</startdate><enddate>201610</enddate><creator>Negro Rama, S.</creator><creator>Valera, M.</creator><creator>Membrillo, A.</creator><creator>Gómez, M.D.</creator><creator>Solé, M.</creator><creator>Menendez-Buxadera, A.</creator><creator>Anaya, G.</creator><creator>Molina, A.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201610</creationdate><title>Quantitative analysis of short- and long-distance racing performance in young and adult horses and association analysis with functional candidate genes in Spanish Trotter horses</title><author>Negro Rama, S. ; Valera, M. ; Membrillo, A. ; Gómez, M.D. ; Solé, M. ; Menendez-Buxadera, A. ; Anaya, G. ; Molina, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4948-496f8a7e6476fa18be1ef372d99180f357150a03fde7a6753afd8ed34c2545e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Breeding</topic><topic>Breeding of animals</topic><topic>Deregression</topic><topic>endurance ability</topic><topic>equine</topic><topic>expected breeding value</topic><topic>Female</topic><topic>Genetic Association Studies</topic><topic>Genotype & phenotype</topic><topic>Horse racing</topic><topic>Horses</topic><topic>Horses - classification</topic><topic>Horses - genetics</topic><topic>Horses - physiology</topic><topic>Male</topic><topic>Physical Conditioning, Animal</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population genetics</topic><topic>SNP</topic><topic>sprinting ability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Negro Rama, S.</creatorcontrib><creatorcontrib>Valera, M.</creatorcontrib><creatorcontrib>Membrillo, A.</creatorcontrib><creatorcontrib>Gómez, M.D.</creatorcontrib><creatorcontrib>Solé, M.</creatorcontrib><creatorcontrib>Menendez-Buxadera, A.</creatorcontrib><creatorcontrib>Anaya, G.</creatorcontrib><creatorcontrib>Molina, A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of animal breeding and genetics (1986)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Negro Rama, S.</au><au>Valera, M.</au><au>Membrillo, A.</au><au>Gómez, M.D.</au><au>Solé, M.</au><au>Menendez-Buxadera, A.</au><au>Anaya, G.</au><au>Molina, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative analysis of short- and long-distance racing performance in young and adult horses and association analysis with functional candidate genes in Spanish Trotter horses</atitle><jtitle>Journal of animal breeding and genetics (1986)</jtitle><addtitle>J. Anim. Breed. Genet</addtitle><date>2016-10</date><risdate>2016</risdate><volume>133</volume><issue>5</issue><spage>347</spage><epage>356</epage><pages>347-356</pages><issn>0931-2668</issn><eissn>1439-0388</eissn><abstract><![CDATA[Summary
The association of five candidate genes with sporting performance in young and adult Spanish Trotter horses (STHs) was performed according to a previous selection based on quantitative analysis of the trait time per kilometre (TPK). A total of 334 516 records of TPK from 5958 STHs were used to estimate the estimated breeding values (EBVs) at different age groups (young and adults horses) throughout the range of distances (1600–2700 m) using a bicharacter random regression model. The heritability estimated by distance ranged from 0.16 to 0.40, with a different range for the two age groups. Considering the animals with the best and the worst deregressed EBV, 321 STHs were selected for SNP genotyping in MSTN, COX4I2, PDK4, DMRT3 and CKM genes. An association analysis based on ridge and logistic regression revealed that the young trotters with genotype GG in PDK4 (p < 0.05) and AA of DMRT3 (p < 0.001) SNPs show the best potential in short‐distance races, while those carrying the genotype AA in DMRT3 (p < 0.001) and CC in CKM (p < 0.05) genes seem to be the best in long‐distance races. Adult trotters with genotype AA in DMRT3 also display greater speed (p < 0.05) and endurance (p < 0.001).]]></abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>26991374</pmid><doi>10.1111/jbg.12208</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of animal breeding and genetics (1986), 2016-10, Vol.133 (5), p.347-356 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Breeding Breeding of animals Deregression endurance ability equine expected breeding value Female Genetic Association Studies Genotype & phenotype Horse racing Horses Horses - classification Horses - genetics Horses - physiology Male Physical Conditioning, Animal Polymorphism, Single Nucleotide Population genetics SNP sprinting ability |
| title | Quantitative analysis of short- and long-distance racing performance in young and adult horses and association analysis with functional candidate genes in Spanish Trotter horses |
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