Decorin Genotypes, Serum Glucose, Heart Rate, and Cerebrovascular Events: The Tampere Adult Population Cardiovascular Risk Study
Decorin is an extracellular matrix proteoglycan that may attenuate progression of atherosclerosis and its complications, such as stroke. Among its multitude of functions, decorin has been suggested to serve as a receptor for resistin, an adipokine involved in energy homeostasis. The GG genotype of t...
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| Veröffentlicht in: | Genetic testing and molecular biomarkers 2016-08, Vol.20 (8), p.416-419 |
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| description | Decorin is an extracellular matrix proteoglycan that may attenuate progression of atherosclerosis and its complications, such as stroke. Among its multitude of functions, decorin has been suggested to serve as a receptor for resistin, an adipokine involved in energy homeostasis. The GG genotype of the decorin polymorphism rs7308752 (A>G) and the CC genotype of the rs516115 (T>C) are associated with decreased plasma resistin levels.
The association of the above decorin genotypes with selected cardiometabolic risk factors and cerebrovascular events was studied in the Tampere adult population cardiovascular risk (TAMRISK) study.
A Finnish cohort of 336 subjects with diagnosed hypertension and 444 controls was analyzed. Samples were genotyped for decorin rs7308752 and rs516115 polymorphisms using a Competitive Allele-Specific PCR (KASP) technique. Cerebrovascular diseases (I60-I69), including transient cerebral ischemic attacks (G45), were followed up from 2005 to 2014.
Subjects with either of decorin rs7308752 genotypes AG/GG had higher serum glucose (p = 0.015) and higher heart rate (p = 0.017) than those with AA genotype. Similarly, decorin rs516115 genotypes TC/CC were associated with higher serum glucose (p = 0.034) and higher frequency of cerebrovascular diseases (p = 0.015) compared to the TT genotype. However, decorin polymorphisms were not associated with hypertension or body mass index.
These two decorin polymorphisms appear to have biological relevance in human vascular pathophysiology. |
| doi_str_mv | 10.1089/gtmb.2016.0049 |
| format | Article |
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The association of the above decorin genotypes with selected cardiometabolic risk factors and cerebrovascular events was studied in the Tampere adult population cardiovascular risk (TAMRISK) study.
A Finnish cohort of 336 subjects with diagnosed hypertension and 444 controls was analyzed. Samples were genotyped for decorin rs7308752 and rs516115 polymorphisms using a Competitive Allele-Specific PCR (KASP) technique. Cerebrovascular diseases (I60-I69), including transient cerebral ischemic attacks (G45), were followed up from 2005 to 2014.
Subjects with either of decorin rs7308752 genotypes AG/GG had higher serum glucose (p = 0.015) and higher heart rate (p = 0.017) than those with AA genotype. Similarly, decorin rs516115 genotypes TC/CC were associated with higher serum glucose (p = 0.034) and higher frequency of cerebrovascular diseases (p = 0.015) compared to the TT genotype. However, decorin polymorphisms were not associated with hypertension or body mass index.
These two decorin polymorphisms appear to have biological relevance in human vascular pathophysiology.</description><identifier>ISSN: 1945-0265</identifier><identifier>EISSN: 1945-0257</identifier><identifier>DOI: 10.1089/gtmb.2016.0049</identifier><identifier>PMID: 27315044</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Alleles ; Arteriosclerosis ; Atherosclerosis ; Blood Glucose - metabolism ; Body mass ; Body mass index ; Body size ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - genetics ; Case-Control Studies ; Cerebrovascular diseases ; Complications ; Decorin ; Decorin - blood ; Decorin - genetics ; Energy balance ; Extracellular matrix ; Female ; Finland ; Gene Frequency ; Gene polymorphism ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype & phenotype ; Genotypes ; Glucose ; Health risk assessment ; Health risks ; Heart rate ; Homeostasis ; Humans ; Hypertension ; Hypertension - blood ; Hypertension - genetics ; Ischemia ; Linkage Disequilibrium ; Male ; Middle Aged ; Polymorphism ; Polymorphism, Single Nucleotide ; Population studies ; Proteoglycans ; Resistin - blood ; Resistin - genetics ; Risk analysis ; Risk factors ; Vascular diseases</subject><ispartof>Genetic testing and molecular biomarkers, 2016-08, Vol.20 (8), p.416-419</ispartof><rights>Copyright Mary Ann Liebert, Inc. Aug 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-581479f6ece4f7f0f2af1bfb6dcf8c373dbdbbb7b897bd75df2bd46a70a64d0a3</citedby><cites>FETCH-LOGICAL-c356t-581479f6ece4f7f0f2af1bfb6dcf8c373dbdbbb7b897bd75df2bd46a70a64d0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27315044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kunnas, Tarja</creatorcontrib><creatorcontrib>Solakivi, Tiina</creatorcontrib><creatorcontrib>Määttä, Kirsi</creatorcontrib><creatorcontrib>Nikkari, Seppo T</creatorcontrib><title>Decorin Genotypes, Serum Glucose, Heart Rate, and Cerebrovascular Events: The Tampere Adult Population Cardiovascular Risk Study</title><title>Genetic testing and molecular biomarkers</title><addtitle>Genet Test Mol Biomarkers</addtitle><description>Decorin is an extracellular matrix proteoglycan that may attenuate progression of atherosclerosis and its complications, such as stroke. Among its multitude of functions, decorin has been suggested to serve as a receptor for resistin, an adipokine involved in energy homeostasis. The GG genotype of the decorin polymorphism rs7308752 (A>G) and the CC genotype of the rs516115 (T>C) are associated with decreased plasma resistin levels.
The association of the above decorin genotypes with selected cardiometabolic risk factors and cerebrovascular events was studied in the Tampere adult population cardiovascular risk (TAMRISK) study.
A Finnish cohort of 336 subjects with diagnosed hypertension and 444 controls was analyzed. Samples were genotyped for decorin rs7308752 and rs516115 polymorphisms using a Competitive Allele-Specific PCR (KASP) technique. Cerebrovascular diseases (I60-I69), including transient cerebral ischemic attacks (G45), were followed up from 2005 to 2014.
Subjects with either of decorin rs7308752 genotypes AG/GG had higher serum glucose (p = 0.015) and higher heart rate (p = 0.017) than those with AA genotype. Similarly, decorin rs516115 genotypes TC/CC were associated with higher serum glucose (p = 0.034) and higher frequency of cerebrovascular diseases (p = 0.015) compared to the TT genotype. However, decorin polymorphisms were not associated with hypertension or body mass index.
These two decorin polymorphisms appear to have biological relevance in human vascular pathophysiology.</description><subject>Alleles</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Blood Glucose - metabolism</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Case-Control Studies</subject><subject>Cerebrovascular diseases</subject><subject>Complications</subject><subject>Decorin</subject><subject>Decorin - blood</subject><subject>Decorin - genetics</subject><subject>Energy balance</subject><subject>Extracellular matrix</subject><subject>Female</subject><subject>Finland</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Glucose</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Heart rate</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - blood</subject><subject>Hypertension - genetics</subject><subject>Ischemia</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population studies</subject><subject>Proteoglycans</subject><subject>Resistin - blood</subject><subject>Resistin - genetics</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Vascular diseases</subject><issn>1945-0265</issn><issn>1945-0257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAQgC0EoqVw5YgsceHQXezEsWNu1VK2SJVA7XK2_BhDShKnflTaGz8dr1qKxInTjDTfjGbmQ-g1JWtKevn-e57MuiGUrwlh8gk6ppJ1K9J04uljzrsj9CKlG0I4a3v-HB01oqUdYewY_foINsRhxluYQ94vkE7xNcQy4e1YbEhwii9Ax4yvdK65nh3eQAQTw51Otow64vM7mHP6gHc_AO_0tNQyPnNlzPhrWCqRhzDjjY5u-NtzNaSf-DoXt3-Jnnk9Jnj1EE_Qt0_nu83F6vLL9vPm7HJl247nVddTJqTnYIF54YlvtKfGG-6s720rWmecMUaYXgrjROd8YxzjWhDNmSO6PUHv7ucuMdwWSFlNQ7IwjnqGUJKifSN6ySmV_4HW13PeM1LRt_-gN6HEuR6iGloXl7KVXaXW95SNIaUIXi1xmHTcK0rUQaM6aFQHjeqgsTa8eRhbzATuEf_jrf0NGlWaRg</recordid><startdate>201608</startdate><enddate>201608</enddate><creator>Kunnas, Tarja</creator><creator>Solakivi, Tiina</creator><creator>Määttä, Kirsi</creator><creator>Nikkari, Seppo T</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201608</creationdate><title>Decorin Genotypes, Serum Glucose, Heart Rate, and Cerebrovascular Events: The Tampere Adult Population Cardiovascular Risk Study</title><author>Kunnas, Tarja ; Solakivi, Tiina ; Määttä, Kirsi ; Nikkari, Seppo T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-581479f6ece4f7f0f2af1bfb6dcf8c373dbdbbb7b897bd75df2bd46a70a64d0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Alleles</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Blood Glucose - metabolism</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - genetics</topic><topic>Case-Control Studies</topic><topic>Cerebrovascular diseases</topic><topic>Complications</topic><topic>Decorin</topic><topic>Decorin - blood</topic><topic>Decorin - genetics</topic><topic>Energy balance</topic><topic>Extracellular matrix</topic><topic>Female</topic><topic>Finland</topic><topic>Gene Frequency</topic><topic>Gene polymorphism</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype & phenotype</topic><topic>Genotypes</topic><topic>Glucose</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Heart rate</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - blood</topic><topic>Hypertension - genetics</topic><topic>Ischemia</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population studies</topic><topic>Proteoglycans</topic><topic>Resistin - blood</topic><topic>Resistin - genetics</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Vascular diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kunnas, Tarja</creatorcontrib><creatorcontrib>Solakivi, Tiina</creatorcontrib><creatorcontrib>Määttä, Kirsi</creatorcontrib><creatorcontrib>Nikkari, Seppo T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genetic testing and molecular biomarkers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kunnas, Tarja</au><au>Solakivi, Tiina</au><au>Määttä, Kirsi</au><au>Nikkari, Seppo T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decorin Genotypes, Serum Glucose, Heart Rate, and Cerebrovascular Events: The Tampere Adult Population Cardiovascular Risk Study</atitle><jtitle>Genetic testing and molecular biomarkers</jtitle><addtitle>Genet Test Mol Biomarkers</addtitle><date>2016-08</date><risdate>2016</risdate><volume>20</volume><issue>8</issue><spage>416</spage><epage>419</epage><pages>416-419</pages><issn>1945-0265</issn><eissn>1945-0257</eissn><abstract>Decorin is an extracellular matrix proteoglycan that may attenuate progression of atherosclerosis and its complications, such as stroke. Among its multitude of functions, decorin has been suggested to serve as a receptor for resistin, an adipokine involved in energy homeostasis. The GG genotype of the decorin polymorphism rs7308752 (A>G) and the CC genotype of the rs516115 (T>C) are associated with decreased plasma resistin levels.
The association of the above decorin genotypes with selected cardiometabolic risk factors and cerebrovascular events was studied in the Tampere adult population cardiovascular risk (TAMRISK) study.
A Finnish cohort of 336 subjects with diagnosed hypertension and 444 controls was analyzed. Samples were genotyped for decorin rs7308752 and rs516115 polymorphisms using a Competitive Allele-Specific PCR (KASP) technique. Cerebrovascular diseases (I60-I69), including transient cerebral ischemic attacks (G45), were followed up from 2005 to 2014.
Subjects with either of decorin rs7308752 genotypes AG/GG had higher serum glucose (p = 0.015) and higher heart rate (p = 0.017) than those with AA genotype. Similarly, decorin rs516115 genotypes TC/CC were associated with higher serum glucose (p = 0.034) and higher frequency of cerebrovascular diseases (p = 0.015) compared to the TT genotype. However, decorin polymorphisms were not associated with hypertension or body mass index.
These two decorin polymorphisms appear to have biological relevance in human vascular pathophysiology.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>27315044</pmid><doi>10.1089/gtmb.2016.0049</doi><tpages>4</tpages></addata></record> |
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| subjects | Alleles Arteriosclerosis Atherosclerosis Blood Glucose - metabolism Body mass Body mass index Body size Cardiovascular diseases Cardiovascular Diseases - blood Cardiovascular Diseases - genetics Case-Control Studies Cerebrovascular diseases Complications Decorin Decorin - blood Decorin - genetics Energy balance Extracellular matrix Female Finland Gene Frequency Gene polymorphism Genetic Association Studies Genetic Predisposition to Disease Genotype & phenotype Genotypes Glucose Health risk assessment Health risks Heart rate Homeostasis Humans Hypertension Hypertension - blood Hypertension - genetics Ischemia Linkage Disequilibrium Male Middle Aged Polymorphism Polymorphism, Single Nucleotide Population studies Proteoglycans Resistin - blood Resistin - genetics Risk analysis Risk factors Vascular diseases |
| title | Decorin Genotypes, Serum Glucose, Heart Rate, and Cerebrovascular Events: The Tampere Adult Population Cardiovascular Risk Study |
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