Altered striatal circuits underlie characteristic personality traits in Parkinson’s disease
Patients with Parkinson’s disease (PD) have been suggested to share personality traits characterised by low novelty-seeking and high harm-avoidance. Although a link between novelty-seeking and dopamine is hypothesised, the link is not fully supported by 6-[ 18 F]fluoro- l -dopa positron emission tom...
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| Veröffentlicht in: | Journal of neurology 2016-09, Vol.263 (9), p.1828-1839 |
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| creator | Ishii, Toru Sawamoto, Nobukatsu Tabu, Hayato Kawashima, Hidekazu Okada, Tomohisa Togashi, Kaori Takahashi, Ryosuke Fukuyama, Hidenao |
| description | Patients with Parkinson’s disease (PD) have been suggested to share personality traits characterised by low novelty-seeking and high harm-avoidance. Although a link between novelty-seeking and dopamine is hypothesised, the link is not fully supported by 6-[
18
F]fluoro-
l
-dopa positron emission tomography (PET) studies. Meanwhile, tractography studies with magnetic resonance imaging (MRI) link personality to the connectivity of the striatum in healthy subjects. Here, we investigated neurochemical and anatomical correlates of characteristic personality traits in PD. Sixteen PD patients and 28 healthy controls were assessed using the Temperament and Character Inventory. All patients and 17 randomly selected controls were scanned with 2β-carbomethoxy-3β-(4-fluorophenyl)-[
N
-
11
C-methyl]tropane ([
11
C]CFT) PET to measure striatal dopamine transporter availability. All subjects were scanned with MRI to evaluate the connectivity of the striatum using probabilistic tractography. PET findings revealed no correlation of novelty-seeking and harm-avoidance with [
11
C]CFT uptake in patients or controls. Novelty-seeking correlated positively with the connectivity strength of the striatum with the hippocampus and amygdala in both patients and controls. Harm-avoidance and the fibre connectivity strength of the striatum including ventral area with the amygdala correlated negatively in patients and positively in controls, which differed significantly between the groups. Our data support the notion that the fibre connectivity of the striatum with limbic and frontal areas underlies the personality profile. Furthermore, our findings suggest that higher harm-avoidance in PD is linked to alterations of the network, including the nucleus accumbens and amygdala. |
| doi_str_mv | 10.1007/s00415-016-8206-0 |
| format | Article |
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18
F]fluoro-
l
-dopa positron emission tomography (PET) studies. Meanwhile, tractography studies with magnetic resonance imaging (MRI) link personality to the connectivity of the striatum in healthy subjects. Here, we investigated neurochemical and anatomical correlates of characteristic personality traits in PD. Sixteen PD patients and 28 healthy controls were assessed using the Temperament and Character Inventory. All patients and 17 randomly selected controls were scanned with 2β-carbomethoxy-3β-(4-fluorophenyl)-[
N
-
11
C-methyl]tropane ([
11
C]CFT) PET to measure striatal dopamine transporter availability. All subjects were scanned with MRI to evaluate the connectivity of the striatum using probabilistic tractography. PET findings revealed no correlation of novelty-seeking and harm-avoidance with [
11
C]CFT uptake in patients or controls. Novelty-seeking correlated positively with the connectivity strength of the striatum with the hippocampus and amygdala in both patients and controls. Harm-avoidance and the fibre connectivity strength of the striatum including ventral area with the amygdala correlated negatively in patients and positively in controls, which differed significantly between the groups. Our data support the notion that the fibre connectivity of the striatum with limbic and frontal areas underlies the personality profile. Furthermore, our findings suggest that higher harm-avoidance in PD is linked to alterations of the network, including the nucleus accumbens and amygdala.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-016-8206-0</identifier><identifier>PMID: 27334907</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Brain Mapping ; Corpus Striatum - diagnostic imaging ; Corpus Striatum - metabolism ; Diffusion Magnetic Resonance Imaging ; Disability Evaluation ; Dopamine Plasma Membrane Transport Proteins - metabolism ; Female ; Humans ; Image Processing, Computer-Assisted ; Male ; Medicine ; Medicine & Public Health ; Mental Status Schedule ; Middle Aged ; Neural Pathways - diagnostic imaging ; Neural Pathways - metabolism ; Neurology ; Neuropsychological Tests ; Neuroradiology ; Neurosciences ; Original Communication ; Parkinson Disease - diagnostic imaging ; Parkinson Disease - drug therapy ; Parkinson Disease - metabolism ; Parkinson Disease - psychology ; Parkinson's disease ; Personality - physiology ; Personality Tests ; Positron-Emission Tomography ; Severity of Illness Index</subject><ispartof>Journal of neurology, 2016-09, Vol.263 (9), p.1828-1839</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-fb2e3a19d433ca8577324a6436c50e7bbea2067b9a41a7eb8513d43e28ee25513</citedby><cites>FETCH-LOGICAL-c514t-fb2e3a19d433ca8577324a6436c50e7bbea2067b9a41a7eb8513d43e28ee25513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-016-8206-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-016-8206-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27928,27929,41492,42561,51323</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27334907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishii, Toru</creatorcontrib><creatorcontrib>Sawamoto, Nobukatsu</creatorcontrib><creatorcontrib>Tabu, Hayato</creatorcontrib><creatorcontrib>Kawashima, Hidekazu</creatorcontrib><creatorcontrib>Okada, Tomohisa</creatorcontrib><creatorcontrib>Togashi, Kaori</creatorcontrib><creatorcontrib>Takahashi, Ryosuke</creatorcontrib><creatorcontrib>Fukuyama, Hidenao</creatorcontrib><title>Altered striatal circuits underlie characteristic personality traits in Parkinson’s disease</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>Patients with Parkinson’s disease (PD) have been suggested to share personality traits characterised by low novelty-seeking and high harm-avoidance. Although a link between novelty-seeking and dopamine is hypothesised, the link is not fully supported by 6-[
18
F]fluoro-
l
-dopa positron emission tomography (PET) studies. Meanwhile, tractography studies with magnetic resonance imaging (MRI) link personality to the connectivity of the striatum in healthy subjects. Here, we investigated neurochemical and anatomical correlates of characteristic personality traits in PD. Sixteen PD patients and 28 healthy controls were assessed using the Temperament and Character Inventory. All patients and 17 randomly selected controls were scanned with 2β-carbomethoxy-3β-(4-fluorophenyl)-[
N
-
11
C-methyl]tropane ([
11
C]CFT) PET to measure striatal dopamine transporter availability. All subjects were scanned with MRI to evaluate the connectivity of the striatum using probabilistic tractography. PET findings revealed no correlation of novelty-seeking and harm-avoidance with [
11
C]CFT uptake in patients or controls. Novelty-seeking correlated positively with the connectivity strength of the striatum with the hippocampus and amygdala in both patients and controls. Harm-avoidance and the fibre connectivity strength of the striatum including ventral area with the amygdala correlated negatively in patients and positively in controls, which differed significantly between the groups. Our data support the notion that the fibre connectivity of the striatum with limbic and frontal areas underlies the personality profile. Furthermore, our findings suggest that higher harm-avoidance in PD is linked to alterations of the network, including the nucleus accumbens and amygdala.</description><subject>Aged</subject><subject>Brain Mapping</subject><subject>Corpus Striatum - diagnostic imaging</subject><subject>Corpus Striatum - metabolism</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Disability Evaluation</subject><subject>Dopamine Plasma Membrane Transport Proteins - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental Status Schedule</subject><subject>Middle Aged</subject><subject>Neural Pathways - diagnostic imaging</subject><subject>Neural Pathways - metabolism</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Communication</subject><subject>Parkinson Disease - diagnostic imaging</subject><subject>Parkinson Disease - drug therapy</subject><subject>Parkinson Disease - metabolism</subject><subject>Parkinson Disease - psychology</subject><subject>Parkinson's disease</subject><subject>Personality - physiology</subject><subject>Personality Tests</subject><subject>Positron-Emission Tomography</subject><subject>Severity of Illness Index</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqN0c1qFEEQB_BGFLNGH8BLGMjFy2j11_TMMQQ_AgE96DE0NT21ScfZmU1XzyE3X8PX80nszSYiAcFTU9Svqin-QryW8FYCuHcMYKStQTZ1q6Cp4YlYSaNVLY3tnooVaAO11dYciBfM1wDQlsZzcaCc1qYDtxIXJ2OmREPFOUXMOFYhprDEzNUyDZTGSFW4woShsMg5hmpLiecJx5hvq5xwR-NUfcH0PU6l8evHT66GyIRML8WzNY5Mr-7fQ_Htw_uvp5_q888fz05Pzutgpcn1ulekUXaD0Tpga53TymBjdBMskOt7wnKe6zs0Eh31rZW6WFItkbKlOBRv9nu3ab5ZiLPfRA40jjjRvLCXrXJtZzrX_AeVDqwuvtDjR_R6XlK5_E41RoHUUJTcq5Bm5kRrv01xg-nWS_C7mPw-Jl9i8ruY_G7m6H7z0m9o-DPxkEsBag-4tKZLSn99_c-tvwHcSJ33</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Ishii, Toru</creator><creator>Sawamoto, Nobukatsu</creator><creator>Tabu, Hayato</creator><creator>Kawashima, Hidekazu</creator><creator>Okada, Tomohisa</creator><creator>Togashi, Kaori</creator><creator>Takahashi, Ryosuke</creator><creator>Fukuyama, Hidenao</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160901</creationdate><title>Altered striatal circuits underlie characteristic personality traits in Parkinson’s disease</title><author>Ishii, Toru ; 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Although a link between novelty-seeking and dopamine is hypothesised, the link is not fully supported by 6-[
18
F]fluoro-
l
-dopa positron emission tomography (PET) studies. Meanwhile, tractography studies with magnetic resonance imaging (MRI) link personality to the connectivity of the striatum in healthy subjects. Here, we investigated neurochemical and anatomical correlates of characteristic personality traits in PD. Sixteen PD patients and 28 healthy controls were assessed using the Temperament and Character Inventory. All patients and 17 randomly selected controls were scanned with 2β-carbomethoxy-3β-(4-fluorophenyl)-[
N
-
11
C-methyl]tropane ([
11
C]CFT) PET to measure striatal dopamine transporter availability. All subjects were scanned with MRI to evaluate the connectivity of the striatum using probabilistic tractography. PET findings revealed no correlation of novelty-seeking and harm-avoidance with [
11
C]CFT uptake in patients or controls. Novelty-seeking correlated positively with the connectivity strength of the striatum with the hippocampus and amygdala in both patients and controls. Harm-avoidance and the fibre connectivity strength of the striatum including ventral area with the amygdala correlated negatively in patients and positively in controls, which differed significantly between the groups. Our data support the notion that the fibre connectivity of the striatum with limbic and frontal areas underlies the personality profile. Furthermore, our findings suggest that higher harm-avoidance in PD is linked to alterations of the network, including the nucleus accumbens and amygdala.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27334907</pmid><doi>10.1007/s00415-016-8206-0</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of neurology, 2016-09, Vol.263 (9), p.1828-1839 |
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| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Aged Brain Mapping Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism Diffusion Magnetic Resonance Imaging Disability Evaluation Dopamine Plasma Membrane Transport Proteins - metabolism Female Humans Image Processing, Computer-Assisted Male Medicine Medicine & Public Health Mental Status Schedule Middle Aged Neural Pathways - diagnostic imaging Neural Pathways - metabolism Neurology Neuropsychological Tests Neuroradiology Neurosciences Original Communication Parkinson Disease - diagnostic imaging Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson Disease - psychology Parkinson's disease Personality - physiology Personality Tests Positron-Emission Tomography Severity of Illness Index |
| title | Altered striatal circuits underlie characteristic personality traits in Parkinson’s disease |
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