Modified protocol including topical minocycline in orabase to manage medication-related osteonecrosis of the jaw cases
Objective Management of medication‐related osteone‐crosis of the jaw (MRONJ) with active infection can be a serious challenge for clinicians. Based on Association of Oral and Maxillofacial Surgeons (AAOMS) recommendations, we have tested a modified treatment protocol using topical minocycline. Study...
Gespeichert in:
| Veröffentlicht in: | Journal of oral pathology & medicine 2016-10, Vol.45 (9), p.718-720 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 720 |
|---|---|
| container_issue | 9 |
| container_start_page | 718 |
| container_title | Journal of oral pathology & medicine |
| container_volume | 45 |
| creator | Karasneh, Jumana A. Al-Eryani, Kamal Clark, Glenn T. Sedghizadeh, Parish P. |
| description | Objective
Management of medication‐related osteone‐crosis of the jaw (MRONJ) with active infection can be a serious challenge for clinicians. Based on Association of Oral and Maxillofacial Surgeons (AAOMS) recommendations, we have tested a modified treatment protocol using topical minocycline.
Study Design
Five patients diagnosed with stage II or III MRONJ lesions were willing to consent to our protocol. In addition to conventional treatment as suggested by the AAOMS, such as, surgical debridement, chlorhexidine irrigation, and systemic antibiotics, we applied 10% minocycline to the lesions once a week for sustained local antibiotic delivery.
Results
All five patients reported pain relief after the first minocycline application. Complete healing occurred in three patients; case three healed completely after the third application, one case continues to improve toward resolution and one withdraws due to other non‐relevant medical problem.
Conclusions
In this study, we are reporting favorable results using a modified protocol with topical minocycline to treat MRONJ lesions. |
| doi_str_mv | 10.1111/jop.12419 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1827892399</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1826645112</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4669-9e820bd3498203916e37455234b581d6528f1bb5bb63309e9302d705866289363</originalsourceid><addsrcrecordid>eNqNkc1v1DAQxS1ERZfCgX8A-QiHtB5_JT6iqiygfoFA9GY5zqR4ceIlzlL2v8fttr0hMZc5zO89ad4j5BWwQyhztErrQ-ASzBOyAM1YxWqQT8mCGSYrroDvk-c5rxiDWkh4Rva5rhUDaRbk91nqQh-wo-spzcmnSMPo46YL4zWd0zp4F-kQxuS3PoYRy5WmybUuYznTwY3uGumAXQHnkMZqwujmYpfyjGlEP6UcMk09nX8gXbkb6os0vyB7vYsZX97vA_Lt_cnX4w_V6cXy4_G708pLrU1lsOGs7YQ0ZQsDGkUtleJCtqqBTive9NC2qm21EMygEYx3NVON1rwxQosD8mbnW777tcE82yFkjzG6EdMmW2h43RgujPkfVGupAHhB3-7Q2-_yhL1dT2Fw09YCs7eN2NKIvWuksK_vbTdtiemRfKigAEc74CZE3P7byX66uHywrHaKUDL-86hw00-ra1Er-_18aeFqqfTnyy_2SvwF6Ayjww</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1826645112</pqid></control><display><type>article</type><title>Modified protocol including topical minocycline in orabase to manage medication-related osteonecrosis of the jaw cases</title><source>Access via Wiley Online Library</source><source>MEDLINE</source><creator>Karasneh, Jumana A. ; Al-Eryani, Kamal ; Clark, Glenn T. ; Sedghizadeh, Parish P.</creator><creatorcontrib>Karasneh, Jumana A. ; Al-Eryani, Kamal ; Clark, Glenn T. ; Sedghizadeh, Parish P.</creatorcontrib><description>Objective
Management of medication‐related osteone‐crosis of the jaw (MRONJ) with active infection can be a serious challenge for clinicians. Based on Association of Oral and Maxillofacial Surgeons (AAOMS) recommendations, we have tested a modified treatment protocol using topical minocycline.
Study Design
Five patients diagnosed with stage II or III MRONJ lesions were willing to consent to our protocol. In addition to conventional treatment as suggested by the AAOMS, such as, surgical debridement, chlorhexidine irrigation, and systemic antibiotics, we applied 10% minocycline to the lesions once a week for sustained local antibiotic delivery.
Results
All five patients reported pain relief after the first minocycline application. Complete healing occurred in three patients; case three healed completely after the third application, one case continues to improve toward resolution and one withdraws due to other non‐relevant medical problem.
Conclusions
In this study, we are reporting favorable results using a modified protocol with topical minocycline to treat MRONJ lesions.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/jop.12419</identifier><identifier>PMID: 26750149</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Administration, Topical ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents - administration & dosage ; biofilm ; bisphosphonate ; Carboxymethylcellulose Sodium - administration & dosage ; Carboxymethylcellulose Sodium - analogs & derivatives ; Dentistry ; Drug Administration Schedule ; Female ; Humans ; Jaw Diseases - chemically induced ; Jaw Diseases - drug therapy ; medication-related osteonecrosis of the jaw ; minocycline ; Minocycline - administration & dosage ; Osteonecrosis - chemically induced ; Osteonecrosis - drug therapy ; Treatment Outcome</subject><ispartof>Journal of oral pathology & medicine, 2016-10, Vol.45 (9), p.718-720</ispartof><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4669-9e820bd3498203916e37455234b581d6528f1bb5bb63309e9302d705866289363</citedby><cites>FETCH-LOGICAL-c4669-9e820bd3498203916e37455234b581d6528f1bb5bb63309e9302d705866289363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjop.12419$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjop.12419$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26750149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karasneh, Jumana A.</creatorcontrib><creatorcontrib>Al-Eryani, Kamal</creatorcontrib><creatorcontrib>Clark, Glenn T.</creatorcontrib><creatorcontrib>Sedghizadeh, Parish P.</creatorcontrib><title>Modified protocol including topical minocycline in orabase to manage medication-related osteonecrosis of the jaw cases</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>Objective
Management of medication‐related osteone‐crosis of the jaw (MRONJ) with active infection can be a serious challenge for clinicians. Based on Association of Oral and Maxillofacial Surgeons (AAOMS) recommendations, we have tested a modified treatment protocol using topical minocycline.
Study Design
Five patients diagnosed with stage II or III MRONJ lesions were willing to consent to our protocol. In addition to conventional treatment as suggested by the AAOMS, such as, surgical debridement, chlorhexidine irrigation, and systemic antibiotics, we applied 10% minocycline to the lesions once a week for sustained local antibiotic delivery.
Results
All five patients reported pain relief after the first minocycline application. Complete healing occurred in three patients; case three healed completely after the third application, one case continues to improve toward resolution and one withdraws due to other non‐relevant medical problem.
Conclusions
In this study, we are reporting favorable results using a modified protocol with topical minocycline to treat MRONJ lesions.</description><subject>Administration, Topical</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>biofilm</subject><subject>bisphosphonate</subject><subject>Carboxymethylcellulose Sodium - administration & dosage</subject><subject>Carboxymethylcellulose Sodium - analogs & derivatives</subject><subject>Dentistry</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Humans</subject><subject>Jaw Diseases - chemically induced</subject><subject>Jaw Diseases - drug therapy</subject><subject>medication-related osteonecrosis of the jaw</subject><subject>minocycline</subject><subject>Minocycline - administration & dosage</subject><subject>Osteonecrosis - chemically induced</subject><subject>Osteonecrosis - drug therapy</subject><subject>Treatment Outcome</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1v1DAQxS1ERZfCgX8A-QiHtB5_JT6iqiygfoFA9GY5zqR4ceIlzlL2v8fttr0hMZc5zO89ad4j5BWwQyhztErrQ-ASzBOyAM1YxWqQT8mCGSYrroDvk-c5rxiDWkh4Rva5rhUDaRbk91nqQh-wo-spzcmnSMPo46YL4zWd0zp4F-kQxuS3PoYRy5WmybUuYznTwY3uGumAXQHnkMZqwujmYpfyjGlEP6UcMk09nX8gXbkb6os0vyB7vYsZX97vA_Lt_cnX4w_V6cXy4_G708pLrU1lsOGs7YQ0ZQsDGkUtleJCtqqBTive9NC2qm21EMygEYx3NVON1rwxQosD8mbnW777tcE82yFkjzG6EdMmW2h43RgujPkfVGupAHhB3-7Q2-_yhL1dT2Fw09YCs7eN2NKIvWuksK_vbTdtiemRfKigAEc74CZE3P7byX66uHywrHaKUDL-86hw00-ra1Er-_18aeFqqfTnyy_2SvwF6Ayjww</recordid><startdate>201610</startdate><enddate>201610</enddate><creator>Karasneh, Jumana A.</creator><creator>Al-Eryani, Kamal</creator><creator>Clark, Glenn T.</creator><creator>Sedghizadeh, Parish P.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201610</creationdate><title>Modified protocol including topical minocycline in orabase to manage medication-related osteonecrosis of the jaw cases</title><author>Karasneh, Jumana A. ; Al-Eryani, Kamal ; Clark, Glenn T. ; Sedghizadeh, Parish P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4669-9e820bd3498203916e37455234b581d6528f1bb5bb63309e9302d705866289363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Administration, Topical</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>biofilm</topic><topic>bisphosphonate</topic><topic>Carboxymethylcellulose Sodium - administration & dosage</topic><topic>Carboxymethylcellulose Sodium - analogs & derivatives</topic><topic>Dentistry</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Humans</topic><topic>Jaw Diseases - chemically induced</topic><topic>Jaw Diseases - drug therapy</topic><topic>medication-related osteonecrosis of the jaw</topic><topic>minocycline</topic><topic>Minocycline - administration & dosage</topic><topic>Osteonecrosis - chemically induced</topic><topic>Osteonecrosis - drug therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karasneh, Jumana A.</creatorcontrib><creatorcontrib>Al-Eryani, Kamal</creatorcontrib><creatorcontrib>Clark, Glenn T.</creatorcontrib><creatorcontrib>Sedghizadeh, Parish P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karasneh, Jumana A.</au><au>Al-Eryani, Kamal</au><au>Clark, Glenn T.</au><au>Sedghizadeh, Parish P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modified protocol including topical minocycline in orabase to manage medication-related osteonecrosis of the jaw cases</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2016-10</date><risdate>2016</risdate><volume>45</volume><issue>9</issue><spage>718</spage><epage>720</epage><pages>718-720</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>Objective
Management of medication‐related osteone‐crosis of the jaw (MRONJ) with active infection can be a serious challenge for clinicians. Based on Association of Oral and Maxillofacial Surgeons (AAOMS) recommendations, we have tested a modified treatment protocol using topical minocycline.
Study Design
Five patients diagnosed with stage II or III MRONJ lesions were willing to consent to our protocol. In addition to conventional treatment as suggested by the AAOMS, such as, surgical debridement, chlorhexidine irrigation, and systemic antibiotics, we applied 10% minocycline to the lesions once a week for sustained local antibiotic delivery.
Results
All five patients reported pain relief after the first minocycline application. Complete healing occurred in three patients; case three healed completely after the third application, one case continues to improve toward resolution and one withdraws due to other non‐relevant medical problem.
Conclusions
In this study, we are reporting favorable results using a modified protocol with topical minocycline to treat MRONJ lesions.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>26750149</pmid><doi>10.1111/jop.12419</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0904-2512 |
| ispartof | Journal of oral pathology & medicine, 2016-10, Vol.45 (9), p.718-720 |
| issn | 0904-2512 1600-0714 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1827892399 |
| source | Access via Wiley Online Library; MEDLINE |
| subjects | Administration, Topical Aged Aged, 80 and over Anti-Bacterial Agents - administration & dosage biofilm bisphosphonate Carboxymethylcellulose Sodium - administration & dosage Carboxymethylcellulose Sodium - analogs & derivatives Dentistry Drug Administration Schedule Female Humans Jaw Diseases - chemically induced Jaw Diseases - drug therapy medication-related osteonecrosis of the jaw minocycline Minocycline - administration & dosage Osteonecrosis - chemically induced Osteonecrosis - drug therapy Treatment Outcome |
| title | Modified protocol including topical minocycline in orabase to manage medication-related osteonecrosis of the jaw cases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T15%3A19%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Modified%20protocol%20including%20topical%20minocycline%20in%20orabase%20to%20manage%20medication-related%20osteonecrosis%20of%20the%20jaw%20cases&rft.jtitle=Journal%20of%20oral%20pathology%20&%20medicine&rft.au=Karasneh,%20Jumana%20A.&rft.date=2016-10&rft.volume=45&rft.issue=9&rft.spage=718&rft.epage=720&rft.pages=718-720&rft.issn=0904-2512&rft.eissn=1600-0714&rft_id=info:doi/10.1111/jop.12419&rft_dat=%3Cproquest_cross%3E1826645112%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1826645112&rft_id=info:pmid/26750149&rfr_iscdi=true |