The dietary effect of milk sphingomyelin on the lipid metabolism of obese/diabetic KK-Ay mice and wild-type C57BL/6J mice

The dietary effect of milk sphingomyelin on the lipid metabolism of obese/diabetic KK-Ay mice and wild-type C57BL/6J mice

Purified milk sphingomyelin (SM) was obtained from lipid concentrated butter serum (LC-BS) by successive separations involving solvent fractionation, selective saponification, and silicic acid column chromatography. The SM obtained was given to obese/diabetic KK-Ay mice and wild-type C57BL/6J mice....

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Veröffentlicht in:Food & function 2016-09, Vol.7 (9), p.3854-3867
Hauptverfasser: Yamauchi, Ippei, Uemura, Mariko, Hosokawa, Masashi, Iwashima-Suzuki, Ai, Shiota, Makoto, Miyashita, Kazuo
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container_title Food & function
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creator Yamauchi, Ippei
Uemura, Mariko
Hosokawa, Masashi
Iwashima-Suzuki, Ai
Shiota, Makoto
Miyashita, Kazuo
description Purified milk sphingomyelin (SM) was obtained from lipid concentrated butter serum (LC-BS) by successive separations involving solvent fractionation, selective saponification, and silicic acid column chromatography. The SM obtained was given to obese/diabetic KK-Ay mice and wild-type C57BL/6J mice. SM supplementation significantly increased fecal lipids paralleled with a decrease in non-HDL cholesterol levels in the serum and neutral lipids and in cholesterol levels in the livers of KK-Ay mice. The reduction of liver lipid levels also resulted in a decrease in the total fatty acid content of the KK-Ay mice livers, while n-3 fatty acids derived from the conversion of alpha -linolenic acid (18:3n-3) increased due to SM supplementation. In contrast to the KK-Ay mice, little change in the serum and liver lipids was observed in wild-type C57BL/6J mice. The present study suggests that SM may be effective only in subjects with metabolic disorders.
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title The dietary effect of milk sphingomyelin on the lipid metabolism of obese/diabetic KK-Ay mice and wild-type C57BL/6J mice
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