Impacts of nicorandil on infarct myocardium in comparison with nitrate: assessed by cardiac magnetic resonance imaging

In this pilot study, we compared the infarct and edema size in acute myocardial infarction (MI) patients treated by nicorandil with those treated by nitrate, using cardiac magnetic resonance (CMR) imaging. Fifty-two acute MI patients who underwent emergency percutaneous coronary intervention (PCI) w...

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Veröffentlicht in:	Heart and vessels 2016-09, Vol.31 (9), p.1430-1437
Hauptverfasser:	Yamada, Kiyoyasu, Isobe, Satoshi, Ishii, Hideki, Yokouchi, Kazuhiko, Iwata, Hirokazu, Sawada, Ken, Murohara, Toyoaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers - blood Biomedical Engineering and Bioengineering Cardiac Surgery Cardiology Coronary Circulation - drug effects Coronary Vessels - diagnostic imaging Coronary Vessels - drug effects Coronary Vessels - physiopathology Creatine Kinase, MB Form - blood Edema Edema, Cardiac - diagnostic imaging Edema, Cardiac - physiopathology Edema, Cardiac - therapy Female Heart attacks Humans Isosorbide Dinitrate - administration & dosage Japan Magnetic Resonance Imaging Male Medicine Medicine & Public Health Middle Aged Myocardial Infarction - diagnostic imaging Myocardial Infarction - physiopathology Myocardial Infarction - therapy Nicorandil - administration & dosage Nitrates Nitroglycerin - administration & dosage NMR Nuclear magnetic resonance Original Article Percutaneous Coronary Intervention - adverse effects Pilot Projects Predictive Value of Tests Studies Time Factors Treatment Outcome Vascular Surgery Vasodilator Agents - administration & dosage
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Zusammenfassung:	In this pilot study, we compared the infarct and edema size in acute myocardial infarction (MI) patients treated by nicorandil with those treated by nitrate, using cardiac magnetic resonance (CMR) imaging. Fifty-two acute MI patients who underwent emergency percutaneous coronary intervention (PCI) were enrolled, and were assigned to receive nicorandil or nitrate at random just before reperfusion. For the assessment of infarct and edema areas, short-axis delayed enhancement (DE) and T2-weight (T2w) CMR images were acquired 6.1 ± 2.4 days after the onset of MI. A significant correlation was observed between the peak creatinine kinase (CK) level and the infarct size on DE CMR ( r = 0.62, p
ISSN:	0910-8327 1615-2573
DOI:	10.1007/s00380-015-0752-3