Improvement of hypertension, endothelial function and systemic inflammation following short-term supplementation with red beet (Beta vulgaris L.) juice: a randomized crossover pilot study
Hypertension is a major risk factor for cardiovascular disease and has a prevalence of about one billion people worldwide. It has been shown that adherence to a diet rich in fruits and vegetables helps in decreasing blood pressure (BP). This study aimed to investigate the effect of raw beet juice (R...
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| description | Hypertension is a major risk factor for cardiovascular disease and has a prevalence of about one billion people worldwide. It has been shown that adherence to a diet rich in fruits and vegetables helps in decreasing blood pressure (BP). This study aimed to investigate the effect of raw beet juice (RBJ) and cooked beet (CB) on BP of hypertensive subjects. In this randomized crossover study, 24 hypertensive subjects aged 25–68 years old were divided into two groups. One group took RBJ for 2 weeks and the other group took CB. After 2 weeks of treatment, both groups had a washout for 2 weeks then switched to the alternate treatment. Each participant consumed 250 ml day
−1
of RBJ or 250 g day
−1
of CB each for a period of 2 weeks. Body weight, BP, flow-mediated dilation (FMD), lipid profile and inflammatory parameters were measured at baseline and after each period. According to the results, high-sensitivity C-reactive protein (hs-CRP) and tumour necrosis factor alpha (TNF-α) were significantly lower and FMD was significantly higher after treatment with RBJ compared with CB (
P |
| doi_str_mv | 10.1038/jhh.2016.34 |
| format | Article |
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−1
of RBJ or 250 g day
−1
of CB each for a period of 2 weeks. Body weight, BP, flow-mediated dilation (FMD), lipid profile and inflammatory parameters were measured at baseline and after each period. According to the results, high-sensitivity C-reactive protein (hs-CRP) and tumour necrosis factor alpha (TNF-α) were significantly lower and FMD was significantly higher after treatment with RBJ compared with CB (
P
<0.05). FMD was significantly (
P
<0.05) increased, but systolic and diastolic BP, intracellular adhesion molecule-1 (ICAM-1), vascular endothelial adhesion molecule-1 (VCAM-1), hs-CRP, interleukin-6, E-selectin and TNF-α were significantly (
P
<0.05) decreased with RBJ or CB. Total antioxidant capacity was increased and non-high-density lipoprotein (HDL), low-density lipoprotein (LDL) and total cholesterol (TC) were decreased with RBJ but not with CB. Although both forms of beetroot were effective in improving BP, endothelial function and systemic inflammation, the raw beetroot juice had greater antihypertensive effects. Also more improvement was observed in endothelial function and systemic inflammation with RBJ compared with CB.</description><identifier>ISSN: 0950-9240</identifier><identifier>EISSN: 1476-5527</identifier><identifier>DOI: 10.1038/jhh.2016.34</identifier><identifier>PMID: 27278926</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>101/6 ; 631/443/592 ; 692/308/2779/109 ; Adult ; Aged ; Antihypertensives ; Antioxidants ; Beets ; Beta vulgaris ; Biomarkers - blood ; Blood pressure ; Body weight ; C-reactive protein ; Cardiovascular diseases ; Care and treatment ; Cholesterol ; Complications and side effects ; Cross-Over Studies ; E-selectin ; Endothelium ; Endothelium, Vascular - drug effects ; Epidemiology ; Health Administration ; Health aspects ; High density lipoprotein ; Humans ; Hypertension ; Hypertension - drug therapy ; Inflammation ; Inflammation - drug therapy ; Intercellular adhesion molecule 1 ; Interleukin 6 ; Juices ; Lipid Metabolism - drug effects ; Low density lipoprotein ; Medicine ; Medicine & Public Health ; Middle Aged ; original-article ; Physiological aspects ; Phytotherapy ; Pilot Projects ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Public Health ; Risk factors ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Tumors ; Vascular cell adhesion molecule 1 ; Vasodilation - drug effects ; Vegetable juices</subject><ispartof>Journal of human hypertension, 2016-10, Vol.30 (10), p.627-632</ispartof><rights>Macmillan Publishers Limited 2016</rights><rights>COPYRIGHT 2016 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Oct 2016</rights><rights>Macmillan Publishers Limited 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-db979e7ab779cd4570057981d5a5d409beea25f6cbae5075a508e3a26c2fe9aa3</citedby><cites>FETCH-LOGICAL-c513t-db979e7ab779cd4570057981d5a5d409beea25f6cbae5075a508e3a26c2fe9aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/jhh.2016.34$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/jhh.2016.34$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27278926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Asgary, S</creatorcontrib><creatorcontrib>Afshani, M R</creatorcontrib><creatorcontrib>Sahebkar, A</creatorcontrib><creatorcontrib>Keshvari, M</creatorcontrib><creatorcontrib>Taheri, M</creatorcontrib><creatorcontrib>Jahanian, E</creatorcontrib><creatorcontrib>Rafieian-Kopaei, M</creatorcontrib><creatorcontrib>Malekian, F</creatorcontrib><creatorcontrib>Sarrafzadegan, N</creatorcontrib><title>Improvement of hypertension, endothelial function and systemic inflammation following short-term supplementation with red beet (Beta vulgaris L.) juice: a randomized crossover pilot study</title><title>Journal of human hypertension</title><addtitle>J Hum Hypertens</addtitle><addtitle>J Hum Hypertens</addtitle><description>Hypertension is a major risk factor for cardiovascular disease and has a prevalence of about one billion people worldwide. It has been shown that adherence to a diet rich in fruits and vegetables helps in decreasing blood pressure (BP). This study aimed to investigate the effect of raw beet juice (RBJ) and cooked beet (CB) on BP of hypertensive subjects. In this randomized crossover study, 24 hypertensive subjects aged 25–68 years old were divided into two groups. One group took RBJ for 2 weeks and the other group took CB. After 2 weeks of treatment, both groups had a washout for 2 weeks then switched to the alternate treatment. Each participant consumed 250 ml day
−1
of RBJ or 250 g day
−1
of CB each for a period of 2 weeks. Body weight, BP, flow-mediated dilation (FMD), lipid profile and inflammatory parameters were measured at baseline and after each period. According to the results, high-sensitivity C-reactive protein (hs-CRP) and tumour necrosis factor alpha (TNF-α) were significantly lower and FMD was significantly higher after treatment with RBJ compared with CB (
P
<0.05). FMD was significantly (
P
<0.05) increased, but systolic and diastolic BP, intracellular adhesion molecule-1 (ICAM-1), vascular endothelial adhesion molecule-1 (VCAM-1), hs-CRP, interleukin-6, E-selectin and TNF-α were significantly (
P
<0.05) decreased with RBJ or CB. Total antioxidant capacity was increased and non-high-density lipoprotein (HDL), low-density lipoprotein (LDL) and total cholesterol (TC) were decreased with RBJ but not with CB. Although both forms of beetroot were effective in improving BP, endothelial function and systemic inflammation, the raw beetroot juice had greater antihypertensive effects. Also more improvement was observed in endothelial function and systemic inflammation with RBJ compared with CB.</description><subject>101/6</subject><subject>631/443/592</subject><subject>692/308/2779/109</subject><subject>Adult</subject><subject>Aged</subject><subject>Antihypertensives</subject><subject>Antioxidants</subject><subject>Beets</subject><subject>Beta vulgaris</subject><subject>Biomarkers - blood</subject><subject>Blood pressure</subject><subject>Body weight</subject><subject>C-reactive protein</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Cholesterol</subject><subject>Complications and side effects</subject><subject>Cross-Over Studies</subject><subject>E-selectin</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Epidemiology</subject><subject>Health Administration</subject><subject>Health aspects</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Intercellular adhesion molecule 1</subject><subject>Interleukin 6</subject><subject>Juices</subject><subject>Lipid Metabolism - drug effects</subject><subject>Low density lipoprotein</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>original-article</subject><subject>Physiological aspects</subject><subject>Phytotherapy</subject><subject>Pilot Projects</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Public Health</subject><subject>Risk factors</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><subject>Tumors</subject><subject>Vascular cell adhesion molecule 1</subject><subject>Vasodilation - drug effects</subject><subject>Vegetable juices</subject><issn>0950-9240</issn><issn>1476-5527</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkt-L1DAQx4so3nr65LsEBDnxuiZpfrS-rYc_DhZ80eeQbafbLGlTk_SO9V_znzPdPfWUQyQPAzOfzMx3ZrLsKcFLgovy9a7rlhQTsSzYvWxBmBQ551Tezxa44jivKMMn2aMQdhjPwfJhdkIllWVFxSL7ftmP3l1BD0NErkXdfgQfYQjGDecIhsbFDqzRFrXTUMfkRXpoUNiHCL2pkRlaq_teHyKts9Zdm2GLQud8zCP4HoVpHO0h_xG6NrFDHhq0AYjo7C1Eja4mu9XeBLRevkS7ydTwBmnkUyXXm2-Jrb0LIbXp0WisiyjEqdk_zh602gZ4cmNPsy_v332--JivP324vFit85qTIubNppIVSL2RsqobxiXGXFYlabjmDcNV6kNT3op6o4Fjmby4hEJTUdMWKq2L0-zsmDdN6usEIarehBqs1QO4KShSpmmWkkv6HyiRJWO84gl9_he6c5MfkhBFBcOC0GT-Rc25cMUKRn5TW21BpZ246HU9l1YrJqgQrCIiUcs7qPSaeZVugNYk_x8fXtz60IG2sQvOTvMeg1oJPk-SHOq_OoKHPXlo1ehNr_1eEazmI1XpSNV8pKqYNT270TRtemh-sT-vMgHnRyCk0LAFf0v0Hfl-ANUu8iQ</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Asgary, S</creator><creator>Afshani, M R</creator><creator>Sahebkar, A</creator><creator>Keshvari, M</creator><creator>Taheri, M</creator><creator>Jahanian, E</creator><creator>Rafieian-Kopaei, M</creator><creator>Malekian, F</creator><creator>Sarrafzadegan, N</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20161001</creationdate><title>Improvement of hypertension, endothelial function and systemic inflammation following short-term supplementation with red beet (Beta vulgaris L.) juice: a randomized crossover pilot study</title><author>Asgary, S ; Afshani, M R ; Sahebkar, A ; Keshvari, M ; Taheri, M ; Jahanian, E ; Rafieian-Kopaei, M ; Malekian, F ; Sarrafzadegan, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-db979e7ab779cd4570057981d5a5d409beea25f6cbae5075a508e3a26c2fe9aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>101/6</topic><topic>631/443/592</topic><topic>692/308/2779/109</topic><topic>Adult</topic><topic>Aged</topic><topic>Antihypertensives</topic><topic>Antioxidants</topic><topic>Beets</topic><topic>Beta vulgaris</topic><topic>Biomarkers - blood</topic><topic>Blood pressure</topic><topic>Body weight</topic><topic>C-reactive protein</topic><topic>Cardiovascular diseases</topic><topic>Care and treatment</topic><topic>Cholesterol</topic><topic>Complications and side effects</topic><topic>Cross-Over Studies</topic><topic>E-selectin</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Epidemiology</topic><topic>Health Administration</topic><topic>Health aspects</topic><topic>High density lipoprotein</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - drug therapy</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Intercellular adhesion molecule 1</topic><topic>Interleukin 6</topic><topic>Juices</topic><topic>Lipid Metabolism - drug effects</topic><topic>Low density lipoprotein</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>original-article</topic><topic>Physiological aspects</topic><topic>Phytotherapy</topic><topic>Pilot Projects</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Public Health</topic><topic>Risk factors</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><topic>Tumors</topic><topic>Vascular cell adhesion molecule 1</topic><topic>Vasodilation - drug effects</topic><topic>Vegetable juices</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asgary, S</creatorcontrib><creatorcontrib>Afshani, M R</creatorcontrib><creatorcontrib>Sahebkar, A</creatorcontrib><creatorcontrib>Keshvari, M</creatorcontrib><creatorcontrib>Taheri, M</creatorcontrib><creatorcontrib>Jahanian, E</creatorcontrib><creatorcontrib>Rafieian-Kopaei, M</creatorcontrib><creatorcontrib>Malekian, F</creatorcontrib><creatorcontrib>Sarrafzadegan, N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of human hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asgary, S</au><au>Afshani, M R</au><au>Sahebkar, A</au><au>Keshvari, M</au><au>Taheri, M</au><au>Jahanian, E</au><au>Rafieian-Kopaei, M</au><au>Malekian, F</au><au>Sarrafzadegan, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improvement of hypertension, endothelial function and systemic inflammation following short-term supplementation with red beet (Beta vulgaris L.) juice: a randomized crossover pilot study</atitle><jtitle>Journal of human hypertension</jtitle><stitle>J Hum Hypertens</stitle><addtitle>J Hum Hypertens</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>30</volume><issue>10</issue><spage>627</spage><epage>632</epage><pages>627-632</pages><issn>0950-9240</issn><eissn>1476-5527</eissn><abstract>Hypertension is a major risk factor for cardiovascular disease and has a prevalence of about one billion people worldwide. It has been shown that adherence to a diet rich in fruits and vegetables helps in decreasing blood pressure (BP). This study aimed to investigate the effect of raw beet juice (RBJ) and cooked beet (CB) on BP of hypertensive subjects. In this randomized crossover study, 24 hypertensive subjects aged 25–68 years old were divided into two groups. One group took RBJ for 2 weeks and the other group took CB. After 2 weeks of treatment, both groups had a washout for 2 weeks then switched to the alternate treatment. Each participant consumed 250 ml day
−1
of RBJ or 250 g day
−1
of CB each for a period of 2 weeks. Body weight, BP, flow-mediated dilation (FMD), lipid profile and inflammatory parameters were measured at baseline and after each period. According to the results, high-sensitivity C-reactive protein (hs-CRP) and tumour necrosis factor alpha (TNF-α) were significantly lower and FMD was significantly higher after treatment with RBJ compared with CB (
P
<0.05). FMD was significantly (
P
<0.05) increased, but systolic and diastolic BP, intracellular adhesion molecule-1 (ICAM-1), vascular endothelial adhesion molecule-1 (VCAM-1), hs-CRP, interleukin-6, E-selectin and TNF-α were significantly (
P
<0.05) decreased with RBJ or CB. Total antioxidant capacity was increased and non-high-density lipoprotein (HDL), low-density lipoprotein (LDL) and total cholesterol (TC) were decreased with RBJ but not with CB. Although both forms of beetroot were effective in improving BP, endothelial function and systemic inflammation, the raw beetroot juice had greater antihypertensive effects. Also more improvement was observed in endothelial function and systemic inflammation with RBJ compared with CB.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27278926</pmid><doi>10.1038/jhh.2016.34</doi><tpages>6</tpages></addata></record> |
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| issn | 0950-9240 1476-5527 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 101/6 631/443/592 692/308/2779/109 Adult Aged Antihypertensives Antioxidants Beets Beta vulgaris Biomarkers - blood Blood pressure Body weight C-reactive protein Cardiovascular diseases Care and treatment Cholesterol Complications and side effects Cross-Over Studies E-selectin Endothelium Endothelium, Vascular - drug effects Epidemiology Health Administration Health aspects High density lipoprotein Humans Hypertension Hypertension - drug therapy Inflammation Inflammation - drug therapy Intercellular adhesion molecule 1 Interleukin 6 Juices Lipid Metabolism - drug effects Low density lipoprotein Medicine Medicine & Public Health Middle Aged original-article Physiological aspects Phytotherapy Pilot Projects Plant Extracts - pharmacology Plant Extracts - therapeutic use Public Health Risk factors Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors Vascular cell adhesion molecule 1 Vasodilation - drug effects Vegetable juices |
| title | Improvement of hypertension, endothelial function and systemic inflammation following short-term supplementation with red beet (Beta vulgaris L.) juice: a randomized crossover pilot study |
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