CD49d prevails over the novel recurrent mutations as independent prognosticator of overall survival in chronic lymphocytic leukemia

CD49d, the alpha-chain of the integrin heterodimer α4β1, was identified among the strongest predictors of overall survival (OS) in chronic lymphocytic leukemia (CLL), along with IGHV mutational status and deletion of the 17p chromosome involving TP53 . In addition to TP53 , the clinical relevance of...

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Veröffentlicht in:	Leukemia 2016-10, Vol.30 (10), p.2011-2018
Hauptverfasser:	Dal Bo, M, Bulian, P, Bomben, R, Zucchetto, A, Rossi, F M, Pozzo, F, Tissino, E, Benedetti, D, Bittolo, T, Nanni, P, Cattarossi, I, Zaina, E, Chivilò, H, Degan, M, Zaja, F, Pozzato, G, Chiarenza, A, Di Raimondo, F, Del Principe, M I, Del Poeta, G, Rossi, D, Gaidano, G, Gattei, V
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/22 45/23 45/77 631/45/612/1236 631/67/1990/283/1895 631/67/68 692/308/575 692/700/1750/1976 Abnormalities Adult Aged Aged, 80 and over Analysis Baculoviral IAP Repeat-Containing 3 Protein Cancer Research Care and treatment CD49d antigen Chemoresistance Chromosome deletion Chromosomes Chronic lymphocytic leukemia Context Critical Care Medicine Diagnosis Gene deletion Gene mutation Genes Hematology Humans Inhibitor of Apoptosis Proteins - genetics Integrin alpha4 - physiology Intensive Internal Medicine Investigations Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis Leukemia, Lymphocytic, Chronic, B-Cell - mortality Lymphatic leukemia Medicine Medicine & Public Health Middle Aged Mutation Notch1 protein Oncology original-article p53 Protein Phosphoproteins - genetics Prognosis Receptors, Antigen, B-Cell - genetics Review boards RNA Splicing Factors - genetics Subgroups Survival Survival Rate Tumor Suppressor Protein p53 - genetics Ubiquitin-Protein Ligases - genetics
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