Preclinical Experimental and Mathematical Approaches for Assessing Effective Doses of Inhaled Drugs, Using Mometasone to Support Human Dose Predictions

Understanding the relationship between dose, lung exposure, and drug efficacy continues to be a challenging aspect of inhaled drug development. An experimental inhalation platform was developed using mometasone furoate to link rodent lung exposure to its in vivo pharmacodynamic (PD) effects. We asse...

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Veröffentlicht in:	Journal of aerosol medicine 2016-08, Vol.29 (4), p.362-377
Hauptverfasser:	Caniga, Michael, Cabal, Antonio, Mehta, Khamir, Ross, David S, Gil, Malgorzata A, Woodhouse, Janice D, Eckman, Joseph, Naber, John R, Callahan, Marissa K, Goncalves, Luciano, Hill, Susan E, Mcleod, Robbie L, McIntosh, Fraser, Freke, Mark C, Visser, Sandra A G, Johnson, Neil, Salmon, Michael, Cicmil, Milenko
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Aerosols Alternaria Alternaria alternata Alternariosis - drug therapy Alternariosis - metabolism Alternariosis - microbiology Alternariosis - physiopathology Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacokinetics Disease Models, Animal Drug Dosage Calculations Health technology assessment Humans Lipopolysaccharides Lung - drug effects Lung - metabolism Lung - physiopathology Lung Diseases, Fungal - drug therapy Lung Diseases, Fungal - metabolism Lung Diseases, Fungal - microbiology Lung Diseases, Fungal - physiopathology Male Models, Biological Mometasone Furoate - administration & dosage Mometasone Furoate - pharmacokinetics Pneumonia - chemically induced Pneumonia - drug therapy Pneumonia - metabolism Pneumonia - physiopathology Rats, Inbred BN Rats, Sprague-Dawley Species Specificity Tissue Distribution
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