Involvement of genes encoding apoptosis regulatory factors ( FAS, FASL , TRAIL , BCL2 , TNFR1 and TNFR2) in the pathogenesis of autoimmune thyroid diseases

Abstract Apoptosis is necessary for the maintenance of self-tolerance by eliminating autoreactive immune cells in the periphery. To clarify the association between the pathogenesis of autoimmune thyroid disease (AITD) and genes encoding apoptosis regulatory factors, we genotyped the FAS –1377G/A, –6...

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Veröffentlicht in:	Human immunology 2016-10, Vol.77 (10), p.944-951
Hauptverfasser:	Inoue, Naoya, Watanabe, Mikio, Ishido, Naoko, Kodu, Arisa, Maruoka, Hayato, Katsumata, Yuka, Hidaka, Yoh, Iwatani, Yoshinori
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Allergy and Immunology Apoptosis Apoptosis - genetics Autoimmune thyroid disease Disease Progression Fas Ligand Protein - genetics fas Receptor - genetics Female Genetic Association Studies Genetic Predisposition to Disease Genotype Graves Disease - genetics Humans Intractability Male Middle Aged Polymorphism Polymorphism, Genetic Proto-Oncogene Proteins c-bcl-2 - genetics Receptors, Tumor Necrosis Factor, Type I - genetics Receptors, Tumor Necrosis Factor, Type II - genetics Severity Thyroiditis, Autoimmune - genetics TNF-Related Apoptosis-Inducing Ligand - genetics
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