Effects of nicardipine on the onset time and intubation conditions of rocuronium-induced neuromuscular blockade
Abstract Study objective The objective of this study was to identify the effects of nicardipine on neuromuscular blockade of rocuronium, such as the onset time and intubation conditions, using a nicardipine dose that attenuates cardiovascular responses during endotracheal intubation. Design Randomiz...
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| Veröffentlicht in: | Journal of clinical anesthesia 2016-08, Vol.32, p.112-118 |
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| creator | Lee, Sun-Yeul, MD Kim, Yoon-Hee, MD, PhD Ko, Young-Kwon, MD, PhD Park, Sang-Il, MD Lee, Jung-Un, MD, PhD Chung, Woo-Suk, MD Lim, Chae-Seong, MD |
| description | Abstract Study objective The objective of this study was to identify the effects of nicardipine on neuromuscular blockade of rocuronium, such as the onset time and intubation conditions, using a nicardipine dose that attenuates cardiovascular responses during endotracheal intubation. Design Randomized, double-blinded, placebo-controlled clinical comparison was used as the design of this study Setting The study was conducted at the operating room of a university hospital. Patients Participants of this study comprise 78 American Society of Anesthesiologists physical status 1 and 2 patients, aged 18 to 60 years who were undergoing elective surgery under general anesthesia. Interventions The nicardipine group was given an intravenous bolus of 20 μ g/kg nicardipine before tracheal intubation: the control group was given an intravenous bolus of a comparable volume of normal saline before tracheal intubation. Measurements Using a TOF-Watch SX monitor, the time from the end of the injection of rocuronium to maximum depression of T1 (onset time) was measured. Intubation was performed 1 minute after rocuronium administration, and the status of the intubation conditions was assessed. The mean blood pressure and heart rate were each measured after endotracheal intubation. Rate pressure product values were also calculated. Main results Intubation conditions were clinically acceptable in 37 (94.9%) of 39 patients in group N compared with 29 (74.4%) of 39 in group C ( P < .05). The onset time of rocuronium was significantly faster in group N than in group C ( P < .05). The mean blood pressure was significantly lower in group N than in group C ( P < .05). The heart rate was significantly higher in group N than in group C ( P < .05). Rate pressure product values showed no significant difference between the two groups ( P > .05). Conclusions Pretreatment with 20 μ g/kg nicardipine improves intubation conditions, shortens the onset time of rocuronium, and attenuates cardiovascular responses to tracheal intubation. |
| doi_str_mv | 10.1016/j.jclinane.2016.02.010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1827886130</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0952818016001380</els_id><sourcerecordid>4091255001</sourcerecordid><originalsourceid>FETCH-LOGICAL-c484t-3aeff38c2ea06435282e7aba907f27057e1482e79f34fd045339c92980b38dec3</originalsourceid><addsrcrecordid>eNqFkstu1TAQhi0EoofCK1SR2LBJGNu5OBsEqspFqsQCWFuOPRZOE_tgx0h9exxOC1I3Xdme-f6xZv4h5IJCQ4H2b-dm1ovzymPDyrsB1gCFJ-RAxcDrtmPjU3KAsWO1oALOyIuUZgAoCfqcnLGBjSUpDiRcWYt6S1WwlXdaReOOzmMVfLX93I-EW7W5FSvlTeX8lie1uZLVwRu33_5KY9A5Bu_yWjtvskZTeSyRNSedFxWraQn6Rhl8SZ5ZtSR8dXeekx8fr75ffq6vv376cvnhutataLeaK7SWC81QQd_yjgmGg5rUCINlA3QD0nYPjZa31pS2OB_1yEYBExcGNT8nb051jzH8ypg2ubqkcVnKxEJOkgo2CNFTDo-jw9j3ohOMFfT1A3QOOfrSyE4NLWspbQvVnygdQ0oRrTxGt6p4KynI3T05y3v35O6eBCaLe0V4cVc-Tyuaf7J7uwrw_gRgGd1vh1Em7dCXcbtYXJQmuMf_ePegxE4V55cbvMX0vx-ZikB-23doXyHaA1AugP8BiOHD0g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1797424114</pqid></control><display><type>article</type><title>Effects of nicardipine on the onset time and intubation conditions of rocuronium-induced neuromuscular blockade</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><source>ProQuest Central UK/Ireland</source><creator>Lee, Sun-Yeul, MD ; Kim, Yoon-Hee, MD, PhD ; Ko, Young-Kwon, MD, PhD ; Park, Sang-Il, MD ; Lee, Jung-Un, MD, PhD ; Chung, Woo-Suk, MD ; Lim, Chae-Seong, MD</creator><creatorcontrib>Lee, Sun-Yeul, MD ; Kim, Yoon-Hee, MD, PhD ; Ko, Young-Kwon, MD, PhD ; Park, Sang-Il, MD ; Lee, Jung-Un, MD, PhD ; Chung, Woo-Suk, MD ; Lim, Chae-Seong, MD</creatorcontrib><description>Abstract Study objective The objective of this study was to identify the effects of nicardipine on neuromuscular blockade of rocuronium, such as the onset time and intubation conditions, using a nicardipine dose that attenuates cardiovascular responses during endotracheal intubation. Design Randomized, double-blinded, placebo-controlled clinical comparison was used as the design of this study Setting The study was conducted at the operating room of a university hospital. Patients Participants of this study comprise 78 American Society of Anesthesiologists physical status 1 and 2 patients, aged 18 to 60 years who were undergoing elective surgery under general anesthesia. Interventions The nicardipine group was given an intravenous bolus of 20 μ g/kg nicardipine before tracheal intubation: the control group was given an intravenous bolus of a comparable volume of normal saline before tracheal intubation. Measurements Using a TOF-Watch SX monitor, the time from the end of the injection of rocuronium to maximum depression of T1 (onset time) was measured. Intubation was performed 1 minute after rocuronium administration, and the status of the intubation conditions was assessed. The mean blood pressure and heart rate were each measured after endotracheal intubation. Rate pressure product values were also calculated. Main results Intubation conditions were clinically acceptable in 37 (94.9%) of 39 patients in group N compared with 29 (74.4%) of 39 in group C ( P < .05). The onset time of rocuronium was significantly faster in group N than in group C ( P < .05). The mean blood pressure was significantly lower in group N than in group C ( P < .05). The heart rate was significantly higher in group N than in group C ( P < .05). Rate pressure product values showed no significant difference between the two groups ( P > .05). Conclusions Pretreatment with 20 μ g/kg nicardipine improves intubation conditions, shortens the onset time of rocuronium, and attenuates cardiovascular responses to tracheal intubation.</description><identifier>ISSN: 0952-8180</identifier><identifier>EISSN: 1873-4529</identifier><identifier>DOI: 10.1016/j.jclinane.2016.02.010</identifier><identifier>PMID: 27290958</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Androstanols - pharmacology ; Anesthesia ; Anesthesia & Perioperative Care ; Calcium Channel Blockers - pharmacology ; Cardiac arrhythmia ; Double-Blind Method ; Drug dosages ; Drug Synergism ; Female ; Heart Rate - drug effects ; Humans ; Hypertension ; Intubation ; Intubation, Intratracheal ; Male ; Middle Aged ; Narcotics ; Neuromuscular blockade ; Neuromuscular Blockade - methods ; Neuromuscular Nondepolarizing Agents - pharmacology ; Nicardipine ; Nicardipine - pharmacology ; Pain Medicine ; Rocuronium ; Studies ; Time Factors ; Young Adult</subject><ispartof>Journal of clinical anesthesia, 2016-08, Vol.32, p.112-118</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Aug 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-3aeff38c2ea06435282e7aba907f27057e1482e79f34fd045339c92980b38dec3</citedby><cites>FETCH-LOGICAL-c484t-3aeff38c2ea06435282e7aba907f27057e1482e79f34fd045339c92980b38dec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1797424114?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27290958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Sun-Yeul, MD</creatorcontrib><creatorcontrib>Kim, Yoon-Hee, MD, PhD</creatorcontrib><creatorcontrib>Ko, Young-Kwon, MD, PhD</creatorcontrib><creatorcontrib>Park, Sang-Il, MD</creatorcontrib><creatorcontrib>Lee, Jung-Un, MD, PhD</creatorcontrib><creatorcontrib>Chung, Woo-Suk, MD</creatorcontrib><creatorcontrib>Lim, Chae-Seong, MD</creatorcontrib><title>Effects of nicardipine on the onset time and intubation conditions of rocuronium-induced neuromuscular blockade</title><title>Journal of clinical anesthesia</title><addtitle>J Clin Anesth</addtitle><description>Abstract Study objective The objective of this study was to identify the effects of nicardipine on neuromuscular blockade of rocuronium, such as the onset time and intubation conditions, using a nicardipine dose that attenuates cardiovascular responses during endotracheal intubation. Design Randomized, double-blinded, placebo-controlled clinical comparison was used as the design of this study Setting The study was conducted at the operating room of a university hospital. Patients Participants of this study comprise 78 American Society of Anesthesiologists physical status 1 and 2 patients, aged 18 to 60 years who were undergoing elective surgery under general anesthesia. Interventions The nicardipine group was given an intravenous bolus of 20 μ g/kg nicardipine before tracheal intubation: the control group was given an intravenous bolus of a comparable volume of normal saline before tracheal intubation. Measurements Using a TOF-Watch SX monitor, the time from the end of the injection of rocuronium to maximum depression of T1 (onset time) was measured. Intubation was performed 1 minute after rocuronium administration, and the status of the intubation conditions was assessed. The mean blood pressure and heart rate were each measured after endotracheal intubation. Rate pressure product values were also calculated. Main results Intubation conditions were clinically acceptable in 37 (94.9%) of 39 patients in group N compared with 29 (74.4%) of 39 in group C ( P < .05). The onset time of rocuronium was significantly faster in group N than in group C ( P < .05). The mean blood pressure was significantly lower in group N than in group C ( P < .05). The heart rate was significantly higher in group N than in group C ( P < .05). Rate pressure product values showed no significant difference between the two groups ( P > .05). Conclusions Pretreatment with 20 μ g/kg nicardipine improves intubation conditions, shortens the onset time of rocuronium, and attenuates cardiovascular responses to tracheal intubation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Androstanols - pharmacology</subject><subject>Anesthesia</subject><subject>Anesthesia & Perioperative Care</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Cardiac arrhythmia</subject><subject>Double-Blind Method</subject><subject>Drug dosages</subject><subject>Drug Synergism</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Intubation</subject><subject>Intubation, Intratracheal</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Narcotics</subject><subject>Neuromuscular blockade</subject><subject>Neuromuscular Blockade - methods</subject><subject>Neuromuscular Nondepolarizing Agents - pharmacology</subject><subject>Nicardipine</subject><subject>Nicardipine - pharmacology</subject><subject>Pain Medicine</subject><subject>Rocuronium</subject><subject>Studies</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>0952-8180</issn><issn>1873-4529</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkstu1TAQhi0EoofCK1SR2LBJGNu5OBsEqspFqsQCWFuOPRZOE_tgx0h9exxOC1I3Xdme-f6xZv4h5IJCQ4H2b-dm1ovzymPDyrsB1gCFJ-RAxcDrtmPjU3KAsWO1oALOyIuUZgAoCfqcnLGBjSUpDiRcWYt6S1WwlXdaReOOzmMVfLX93I-EW7W5FSvlTeX8lie1uZLVwRu33_5KY9A5Bu_yWjtvskZTeSyRNSedFxWraQn6Rhl8SZ5ZtSR8dXeekx8fr75ffq6vv376cvnhutataLeaK7SWC81QQd_yjgmGg5rUCINlA3QD0nYPjZa31pS2OB_1yEYBExcGNT8nb051jzH8ypg2ubqkcVnKxEJOkgo2CNFTDo-jw9j3ohOMFfT1A3QOOfrSyE4NLWspbQvVnygdQ0oRrTxGt6p4KynI3T05y3v35O6eBCaLe0V4cVc-Tyuaf7J7uwrw_gRgGd1vh1Em7dCXcbtYXJQmuMf_ePegxE4V55cbvMX0vx-ZikB-23doXyHaA1AugP8BiOHD0g</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Lee, Sun-Yeul, MD</creator><creator>Kim, Yoon-Hee, MD, PhD</creator><creator>Ko, Young-Kwon, MD, PhD</creator><creator>Park, Sang-Il, MD</creator><creator>Lee, Jung-Un, MD, PhD</creator><creator>Chung, Woo-Suk, MD</creator><creator>Lim, Chae-Seong, MD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20160801</creationdate><title>Effects of nicardipine on the onset time and intubation conditions of rocuronium-induced neuromuscular blockade</title><author>Lee, Sun-Yeul, MD ; Kim, Yoon-Hee, MD, PhD ; Ko, Young-Kwon, MD, PhD ; Park, Sang-Il, MD ; Lee, Jung-Un, MD, PhD ; Chung, Woo-Suk, MD ; Lim, Chae-Seong, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-3aeff38c2ea06435282e7aba907f27057e1482e79f34fd045339c92980b38dec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Androstanols - pharmacology</topic><topic>Anesthesia</topic><topic>Anesthesia & Perioperative Care</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>Cardiac arrhythmia</topic><topic>Double-Blind Method</topic><topic>Drug dosages</topic><topic>Drug Synergism</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Intubation</topic><topic>Intubation, Intratracheal</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Narcotics</topic><topic>Neuromuscular blockade</topic><topic>Neuromuscular Blockade - methods</topic><topic>Neuromuscular Nondepolarizing Agents - pharmacology</topic><topic>Nicardipine</topic><topic>Nicardipine - pharmacology</topic><topic>Pain Medicine</topic><topic>Rocuronium</topic><topic>Studies</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Sun-Yeul, MD</creatorcontrib><creatorcontrib>Kim, Yoon-Hee, MD, PhD</creatorcontrib><creatorcontrib>Ko, Young-Kwon, MD, PhD</creatorcontrib><creatorcontrib>Park, Sang-Il, MD</creatorcontrib><creatorcontrib>Lee, Jung-Un, MD, PhD</creatorcontrib><creatorcontrib>Chung, Woo-Suk, MD</creatorcontrib><creatorcontrib>Lim, Chae-Seong, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of clinical anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Sun-Yeul, MD</au><au>Kim, Yoon-Hee, MD, PhD</au><au>Ko, Young-Kwon, MD, PhD</au><au>Park, Sang-Il, MD</au><au>Lee, Jung-Un, MD, PhD</au><au>Chung, Woo-Suk, MD</au><au>Lim, Chae-Seong, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of nicardipine on the onset time and intubation conditions of rocuronium-induced neuromuscular blockade</atitle><jtitle>Journal of clinical anesthesia</jtitle><addtitle>J Clin Anesth</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>32</volume><spage>112</spage><epage>118</epage><pages>112-118</pages><issn>0952-8180</issn><eissn>1873-4529</eissn><abstract>Abstract Study objective The objective of this study was to identify the effects of nicardipine on neuromuscular blockade of rocuronium, such as the onset time and intubation conditions, using a nicardipine dose that attenuates cardiovascular responses during endotracheal intubation. Design Randomized, double-blinded, placebo-controlled clinical comparison was used as the design of this study Setting The study was conducted at the operating room of a university hospital. Patients Participants of this study comprise 78 American Society of Anesthesiologists physical status 1 and 2 patients, aged 18 to 60 years who were undergoing elective surgery under general anesthesia. Interventions The nicardipine group was given an intravenous bolus of 20 μ g/kg nicardipine before tracheal intubation: the control group was given an intravenous bolus of a comparable volume of normal saline before tracheal intubation. Measurements Using a TOF-Watch SX monitor, the time from the end of the injection of rocuronium to maximum depression of T1 (onset time) was measured. Intubation was performed 1 minute after rocuronium administration, and the status of the intubation conditions was assessed. The mean blood pressure and heart rate were each measured after endotracheal intubation. Rate pressure product values were also calculated. Main results Intubation conditions were clinically acceptable in 37 (94.9%) of 39 patients in group N compared with 29 (74.4%) of 39 in group C ( P < .05). The onset time of rocuronium was significantly faster in group N than in group C ( P < .05). The mean blood pressure was significantly lower in group N than in group C ( P < .05). The heart rate was significantly higher in group N than in group C ( P < .05). Rate pressure product values showed no significant difference between the two groups ( P > .05). Conclusions Pretreatment with 20 μ g/kg nicardipine improves intubation conditions, shortens the onset time of rocuronium, and attenuates cardiovascular responses to tracheal intubation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27290958</pmid><doi>10.1016/j.jclinane.2016.02.010</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of clinical anesthesia, 2016-08, Vol.32, p.112-118 |
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| subjects | Adolescent Adult Androstanols - pharmacology Anesthesia Anesthesia & Perioperative Care Calcium Channel Blockers - pharmacology Cardiac arrhythmia Double-Blind Method Drug dosages Drug Synergism Female Heart Rate - drug effects Humans Hypertension Intubation Intubation, Intratracheal Male Middle Aged Narcotics Neuromuscular blockade Neuromuscular Blockade - methods Neuromuscular Nondepolarizing Agents - pharmacology Nicardipine Nicardipine - pharmacology Pain Medicine Rocuronium Studies Time Factors Young Adult |
| title | Effects of nicardipine on the onset time and intubation conditions of rocuronium-induced neuromuscular blockade |
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