Exploring the In Vitro Resistance of Candida parapsilosis to Echinocandins
The naturally high minimum inhibitory concentration exhibited by echinocandins against Candida parapsilosis has been known since the first introduction of these antifungal agents. Despite this awareness, clinical failures have not been reported; consequently, the resistance of C. parapsilosis to ech...
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| Veröffentlicht in: | Mycopathologia (1975) 2016-10, Vol.181 (9-10), p.663-670 |
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| container_title | Mycopathologia (1975) |
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| creator | Chassot, Francieli Venturini, Tarcieli Pozzebon Piasentin, Fernanda Baldissera Rossato, Luana Fiorini, Adriana Svidzinski, Terezinha Inez Estivalet Alves, Sydney Hartz |
| description | The naturally high minimum inhibitory concentration exhibited by echinocandins against
Candida parapsilosis
has been known since the first introduction of these antifungal agents. Despite this awareness, clinical failures have not been reported; consequently, the resistance of
C. parapsilosis
to echinocandins remains unexplored. We exposed 30 isolates of
C. parapsilosis
to echinocandins (caspofungin, micafungin, and anidulafungin) in vitro and studied the effects of this exposure. After 60 exposures, 80, 67, and 60 % of the isolates changed from susceptible to non-susceptible to caspofungin, micafungin, and anidulafungin, respectively. In addition, four strains exhibited cross-resistance to all three echinocandins. Based on the M27-A3 (CLSI, 2008) and M27-S4 (CLSI, 2012) techniques, the susceptibility of the resistant strains to other antifungal agents was assayed. All of the tested echinocandin-resistant strains were susceptible to amphotericin B, and the resistance rate to fluconazole, voriconazole, and flucytosine was 73.3, 43.3, and 20 %, respectively. The exposure of
C. parapsilosis
to the three echinocandins generated cross-resistant strains and an unexpected in vitro resistance to azoles and flucytosine. |
| doi_str_mv | 10.1007/s11046-016-0028-1 |
| format | Article |
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Candida parapsilosis
has been known since the first introduction of these antifungal agents. Despite this awareness, clinical failures have not been reported; consequently, the resistance of
C. parapsilosis
to echinocandins remains unexplored. We exposed 30 isolates of
C. parapsilosis
to echinocandins (caspofungin, micafungin, and anidulafungin) in vitro and studied the effects of this exposure. After 60 exposures, 80, 67, and 60 % of the isolates changed from susceptible to non-susceptible to caspofungin, micafungin, and anidulafungin, respectively. In addition, four strains exhibited cross-resistance to all three echinocandins. Based on the M27-A3 (CLSI, 2008) and M27-S4 (CLSI, 2012) techniques, the susceptibility of the resistant strains to other antifungal agents was assayed. All of the tested echinocandin-resistant strains were susceptible to amphotericin B, and the resistance rate to fluconazole, voriconazole, and flucytosine was 73.3, 43.3, and 20 %, respectively. The exposure of
C. parapsilosis
to the three echinocandins generated cross-resistant strains and an unexpected in vitro resistance to azoles and flucytosine.</description><identifier>ISSN: 0301-486X</identifier><identifier>EISSN: 1573-0832</identifier><identifier>DOI: 10.1007/s11046-016-0028-1</identifier><identifier>PMID: 27318852</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Antifungal agents ; Antifungal Agents - pharmacology ; Antiparasitic agents ; Azoles - pharmacology ; Biomedical and Life Sciences ; Candida - drug effects ; Candida parapsilosis ; Candidiasis - microbiology ; Drug Resistance, Fungal ; Echinocandins - pharmacology ; Eukaryotic Microbiology ; Glucose ; Humans ; Life Sciences ; Medical Microbiology ; Microbial Ecology ; Microbial Sensitivity Tests ; Microbiology ; Plant Sciences</subject><ispartof>Mycopathologia (1975), 2016-10, Vol.181 (9-10), p.663-670</ispartof><rights>Springer Science+Business Media Dordrecht 2016</rights><rights>COPYRIGHT 2016 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-3791709963f995d69437dd930b69d784b748abbaae2daa49ff2c8086431c3bdc3</citedby><cites>FETCH-LOGICAL-c506t-3791709963f995d69437dd930b69d784b748abbaae2daa49ff2c8086431c3bdc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11046-016-0028-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11046-016-0028-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27318852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chassot, Francieli</creatorcontrib><creatorcontrib>Venturini, Tarcieli Pozzebon</creatorcontrib><creatorcontrib>Piasentin, Fernanda Baldissera</creatorcontrib><creatorcontrib>Rossato, Luana</creatorcontrib><creatorcontrib>Fiorini, Adriana</creatorcontrib><creatorcontrib>Svidzinski, Terezinha Inez Estivalet</creatorcontrib><creatorcontrib>Alves, Sydney Hartz</creatorcontrib><title>Exploring the In Vitro Resistance of Candida parapsilosis to Echinocandins</title><title>Mycopathologia (1975)</title><addtitle>Mycopathologia</addtitle><addtitle>Mycopathologia</addtitle><description>The naturally high minimum inhibitory concentration exhibited by echinocandins against
Candida parapsilosis
has been known since the first introduction of these antifungal agents. Despite this awareness, clinical failures have not been reported; consequently, the resistance of
C. parapsilosis
to echinocandins remains unexplored. We exposed 30 isolates of
C. parapsilosis
to echinocandins (caspofungin, micafungin, and anidulafungin) in vitro and studied the effects of this exposure. After 60 exposures, 80, 67, and 60 % of the isolates changed from susceptible to non-susceptible to caspofungin, micafungin, and anidulafungin, respectively. In addition, four strains exhibited cross-resistance to all three echinocandins. Based on the M27-A3 (CLSI, 2008) and M27-S4 (CLSI, 2012) techniques, the susceptibility of the resistant strains to other antifungal agents was assayed. All of the tested echinocandin-resistant strains were susceptible to amphotericin B, and the resistance rate to fluconazole, voriconazole, and flucytosine was 73.3, 43.3, and 20 %, respectively. The exposure of
C. parapsilosis
to the three echinocandins generated cross-resistant strains and an unexpected in vitro resistance to azoles and flucytosine.</description><subject>Antifungal agents</subject><subject>Antifungal Agents - pharmacology</subject><subject>Antiparasitic agents</subject><subject>Azoles - pharmacology</subject><subject>Biomedical and Life Sciences</subject><subject>Candida - drug effects</subject><subject>Candida parapsilosis</subject><subject>Candidiasis - microbiology</subject><subject>Drug Resistance, Fungal</subject><subject>Echinocandins - pharmacology</subject><subject>Eukaryotic Microbiology</subject><subject>Glucose</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Medical Microbiology</subject><subject>Microbial Ecology</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Plant Sciences</subject><issn>0301-486X</issn><issn>1573-0832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkltrFDEYhoModq3-AG9kwBt7MTWnyeGyLGtdKQj1gHchk2S2KbPJmGSg_nszbD2sKEgIgXzP-8ELDwDPETxHEPLXGSFIWQtRvRCLFj0AK9Rx0kJB8EOwggSilgr25QQ8yfkWwppC_DE4wZwgITq8Au82d9MYkw-7pty4Zhuaz76k2Fy77HPRwbgmDs1aB-utbiad9JT9GOuwKbHZmBsfolmmIT8FjwY9Zvfs_j0Fn95sPq7ftlfvL7fri6vWdJCVlnCJOJSSkUHKzjJJCbdWEtgzabmgPadC973WDlutqRwGbAQUjBJkSG8NOQWvDnunFL_OLhe199m4cdTBxTkrJDBfylH6HygShFRUVvTlH-htnFOoRRaKU8k6Rn9ROz065cMQS9JmWaouKIcUCYpZpc7_QtVj3d6bGNzg6_9R4OwoUJni7spOzzmr7YfrYxYdWJNizskNakp-r9M3haBatFAHLVTVQi1aKFQzL-7Lzf3e2Z-JHx5UAB-APC0uuPRb-39u_Q7fTr3G</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Chassot, Francieli</creator><creator>Venturini, Tarcieli Pozzebon</creator><creator>Piasentin, Fernanda Baldissera</creator><creator>Rossato, Luana</creator><creator>Fiorini, Adriana</creator><creator>Svidzinski, Terezinha Inez Estivalet</creator><creator>Alves, Sydney Hartz</creator><general>Springer Netherlands</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20161001</creationdate><title>Exploring the In Vitro Resistance of Candida parapsilosis to Echinocandins</title><author>Chassot, Francieli ; 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Candida parapsilosis
has been known since the first introduction of these antifungal agents. Despite this awareness, clinical failures have not been reported; consequently, the resistance of
C. parapsilosis
to echinocandins remains unexplored. We exposed 30 isolates of
C. parapsilosis
to echinocandins (caspofungin, micafungin, and anidulafungin) in vitro and studied the effects of this exposure. After 60 exposures, 80, 67, and 60 % of the isolates changed from susceptible to non-susceptible to caspofungin, micafungin, and anidulafungin, respectively. In addition, four strains exhibited cross-resistance to all three echinocandins. Based on the M27-A3 (CLSI, 2008) and M27-S4 (CLSI, 2012) techniques, the susceptibility of the resistant strains to other antifungal agents was assayed. All of the tested echinocandin-resistant strains were susceptible to amphotericin B, and the resistance rate to fluconazole, voriconazole, and flucytosine was 73.3, 43.3, and 20 %, respectively. The exposure of
C. parapsilosis
to the three echinocandins generated cross-resistant strains and an unexpected in vitro resistance to azoles and flucytosine.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>27318852</pmid><doi>10.1007/s11046-016-0028-1</doi><tpages>8</tpages></addata></record> |
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| subjects | Antifungal agents Antifungal Agents - pharmacology Antiparasitic agents Azoles - pharmacology Biomedical and Life Sciences Candida - drug effects Candida parapsilosis Candidiasis - microbiology Drug Resistance, Fungal Echinocandins - pharmacology Eukaryotic Microbiology Glucose Humans Life Sciences Medical Microbiology Microbial Ecology Microbial Sensitivity Tests Microbiology Plant Sciences |
| title | Exploring the In Vitro Resistance of Candida parapsilosis to Echinocandins |
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