A rifampicin-resistant (rpoB) mutation in Pseudomonas protegens Pf-5 strain leads to improved antifungal activity and elevated production of secondary metabolites

Ribosome engineering has proven to be a practical method for increasing antibiotic production, and is extensively applied to strain improvement in antibiotic production and activation of silent genes in several prokaryotes. In this study, ribosome engineering was used to improve production of bioact...

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Veröffentlicht in:	Research in microbiology 2016-10, Vol.167 (8), p.625-629
Hauptverfasser:	Xie, Yali, Liu, Zhengqiang, Zhang, Guoyong, Mo, Xiangtao, Ding, Xuezhi, Xia, Liqiu, Hu, Shengbiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiosis Antibiotics, Antitubercular - pharmacology Antifungal activity Antifungal Agents - metabolism Biological Products - metabolism Chromatography, High Pressure Liquid DNA-Directed RNA Polymerases - genetics Drug Resistance, Bacterial Mutation, Missense Pseudomonas Pseudomonas - drug effects Pseudomonas - metabolism Pseudomonas protegens Ribosome engineering Rifampicin resistance Rifampin - pharmacology Secondary Metabolism Secondary metabolite
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