AXIN2 Polymorphisms and Their Association with Colorectal Cancer in Mexican Patients
The aim of this study was to investigate the association of the rs2240308 and rs1133683 polymorphisms in the AXIN2 gene with colorectal cancer (CRC) in Mexican patients. Genomic DNAs from 201 CRC patients and 100 healthy blood donors were analyzed for AXIN2 gene polymorphisms by polymerase chain rea...
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| Veröffentlicht in: | Genetic testing and molecular biomarkers 2016-08, Vol.20 (8), p.438-444 |
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| creator | Rosales-Reynoso, Mónica Alejandra Arredondo-Valdez, Abril Renee Wence-Chávez, Laura Ivonne Barros-Núñez, Patricio Gallegos-Arreola, Martha P Flores-Martínez, Silvia Esperanza Sánchez-Corona, Jose |
| description | The aim of this study was to investigate the association of the rs2240308 and rs1133683 polymorphisms in the AXIN2 gene with colorectal cancer (CRC) in Mexican patients.
Genomic DNAs from 201 CRC patients and 100 healthy blood donors were analyzed for AXIN2 gene polymorphisms by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Statistical associations were calculated using the odds ratio (OR) test.
The genotype distribution of the rs1133683 polymorphism C > T showed a statistical difference between the two study groups (p = 0.0019). Moreover, OR analyses demonstrated that individuals with either the C/T or T/T genotype have a decreased risk for CRC compared with individuals with the C/C genotype (OR = 0.47, 95% confidence interval [CI] = 0.25-0.86, p = 0.0134 and OR = 0.24, 95% CI = 0.10-0.57, p = 0.005, respectively). This association was also evident in a stratified analysis based on tumor-node-metastasis (TNM) stage. For the rs2240308 polymorphism C > T, the OR analysis showed a significantly increased risk for carriers of the T/T genotype (OR = 2.64, 95% CI = 1.12-6.24, p = 0.0236) and this association was also evident in the stratified analysis by TNM stage.
Our results indicate the possibility that variations in the AXIN2 gene may play a significant role in promoting or preventing CRC development. |
| doi_str_mv | 10.1089/gtmb.2016.0026 |
| format | Article |
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Genomic DNAs from 201 CRC patients and 100 healthy blood donors were analyzed for AXIN2 gene polymorphisms by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Statistical associations were calculated using the odds ratio (OR) test.
The genotype distribution of the rs1133683 polymorphism C > T showed a statistical difference between the two study groups (p = 0.0019). Moreover, OR analyses demonstrated that individuals with either the C/T or T/T genotype have a decreased risk for CRC compared with individuals with the C/C genotype (OR = 0.47, 95% confidence interval [CI] = 0.25-0.86, p = 0.0134 and OR = 0.24, 95% CI = 0.10-0.57, p = 0.005, respectively). This association was also evident in a stratified analysis based on tumor-node-metastasis (TNM) stage. For the rs2240308 polymorphism C > T, the OR analysis showed a significantly increased risk for carriers of the T/T genotype (OR = 2.64, 95% CI = 1.12-6.24, p = 0.0236) and this association was also evident in the stratified analysis by TNM stage.
Our results indicate the possibility that variations in the AXIN2 gene may play a significant role in promoting or preventing CRC development.</description><identifier>ISSN: 1945-0265</identifier><identifier>EISSN: 1945-0257</identifier><identifier>DOI: 10.1089/gtmb.2016.0026</identifier><identifier>PMID: 27228364</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adenocarcinoma - epidemiology ; Adenocarcinoma - genetics ; Adenocarcinoma - metabolism ; Adult ; Alleles ; Axin Protein - genetics ; Axin Protein - metabolism ; Blood donors ; Cancer ; Case-Control Studies ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - epidemiology ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - metabolism ; Confidence intervals ; Female ; Gene Frequency ; Gene polymorphism ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype & phenotype ; Humans ; Male ; Metastases ; Mexico - epidemiology ; Middle Aged ; Patients ; Polymerase chain reaction ; Polymorphism ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Restriction fragment length polymorphism ; Statistical analysis ; Statistics</subject><ispartof>Genetic testing and molecular biomarkers, 2016-08, Vol.20 (8), p.438-444</ispartof><rights>Copyright Mary Ann Liebert, Inc. Aug 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-7c62683554da239c4cb8dcfcd35743f9779a36b4a8c90347e5cbbbf75148ee003</citedby><cites>FETCH-LOGICAL-c356t-7c62683554da239c4cb8dcfcd35743f9779a36b4a8c90347e5cbbbf75148ee003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27228364$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosales-Reynoso, Mónica Alejandra</creatorcontrib><creatorcontrib>Arredondo-Valdez, Abril Renee</creatorcontrib><creatorcontrib>Wence-Chávez, Laura Ivonne</creatorcontrib><creatorcontrib>Barros-Núñez, Patricio</creatorcontrib><creatorcontrib>Gallegos-Arreola, Martha P</creatorcontrib><creatorcontrib>Flores-Martínez, Silvia Esperanza</creatorcontrib><creatorcontrib>Sánchez-Corona, Jose</creatorcontrib><title>AXIN2 Polymorphisms and Their Association with Colorectal Cancer in Mexican Patients</title><title>Genetic testing and molecular biomarkers</title><addtitle>Genet Test Mol Biomarkers</addtitle><description>The aim of this study was to investigate the association of the rs2240308 and rs1133683 polymorphisms in the AXIN2 gene with colorectal cancer (CRC) in Mexican patients.
Genomic DNAs from 201 CRC patients and 100 healthy blood donors were analyzed for AXIN2 gene polymorphisms by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Statistical associations were calculated using the odds ratio (OR) test.
The genotype distribution of the rs1133683 polymorphism C > T showed a statistical difference between the two study groups (p = 0.0019). Moreover, OR analyses demonstrated that individuals with either the C/T or T/T genotype have a decreased risk for CRC compared with individuals with the C/C genotype (OR = 0.47, 95% confidence interval [CI] = 0.25-0.86, p = 0.0134 and OR = 0.24, 95% CI = 0.10-0.57, p = 0.005, respectively). This association was also evident in a stratified analysis based on tumor-node-metastasis (TNM) stage. For the rs2240308 polymorphism C > T, the OR analysis showed a significantly increased risk for carriers of the T/T genotype (OR = 2.64, 95% CI = 1.12-6.24, p = 0.0236) and this association was also evident in the stratified analysis by TNM stage.
Our results indicate the possibility that variations in the AXIN2 gene may play a significant role in promoting or preventing CRC development.</description><subject>Adenocarcinoma - epidemiology</subject><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adult</subject><subject>Alleles</subject><subject>Axin Protein - genetics</subject><subject>Axin Protein - metabolism</subject><subject>Blood donors</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - epidemiology</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Confidence intervals</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Male</subject><subject>Metastases</subject><subject>Mexico - epidemiology</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Promoter Regions, Genetic</subject><subject>Restriction fragment length polymorphism</subject><subject>Statistical analysis</subject><subject>Statistics</subject><issn>1945-0265</issn><issn>1945-0257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkbtPwzAQhy0EolBYGZElFpYWv-2MVcWjEo8ORWKzHMehRklc7FTQ_55ELR2YmO6G7366uw-AC4zGGKns5r2t8zFBWIwRIuIAnOCM8REiXB7ue8EH4DSlD4QEo0ocgwGRhCgq2AlYTN5mzwTOQ7WpQ1wtfaoTNE0BF0vnI5ykFKw3rQ8N_PLtEk5DFaKzrang1DTWRegb-OS-vTUNnHega9p0Bo5KUyV3vqtD8Hp3u5g-jB5f7mfTyePIUi7akbSCCEU5Z4UhNLPM5qqwpS0ol4yWmZSZoSJnRtkMUSYdt3mel5JjppxDiA7B9TZ3FcPn2qVW1z5ZV1WmcWGdNFZEKkUJF_9Au3cKSXCfevUH_Qjr2HSHaIK7xbNMKd5R4y1lY0gpulKvoq9N3GiMdK9G92p0r0b3arqBy13sOq9dscd_XdAf7v2IeQ</recordid><startdate>201608</startdate><enddate>201608</enddate><creator>Rosales-Reynoso, Mónica Alejandra</creator><creator>Arredondo-Valdez, Abril Renee</creator><creator>Wence-Chávez, Laura Ivonne</creator><creator>Barros-Núñez, Patricio</creator><creator>Gallegos-Arreola, Martha P</creator><creator>Flores-Martínez, Silvia Esperanza</creator><creator>Sánchez-Corona, Jose</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201608</creationdate><title>AXIN2 Polymorphisms and Their Association with Colorectal Cancer in Mexican Patients</title><author>Rosales-Reynoso, Mónica Alejandra ; Arredondo-Valdez, Abril Renee ; Wence-Chávez, Laura Ivonne ; Barros-Núñez, Patricio ; Gallegos-Arreola, Martha P ; Flores-Martínez, Silvia Esperanza ; Sánchez-Corona, Jose</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-7c62683554da239c4cb8dcfcd35743f9779a36b4a8c90347e5cbbbf75148ee003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenocarcinoma - epidemiology</topic><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adult</topic><topic>Alleles</topic><topic>Axin Protein - genetics</topic><topic>Axin Protein - metabolism</topic><topic>Blood donors</topic><topic>Cancer</topic><topic>Case-Control Studies</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - epidemiology</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Confidence intervals</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Gene polymorphism</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Male</topic><topic>Metastases</topic><topic>Mexico - epidemiology</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Promoter Regions, Genetic</topic><topic>Restriction fragment length polymorphism</topic><topic>Statistical analysis</topic><topic>Statistics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosales-Reynoso, Mónica Alejandra</creatorcontrib><creatorcontrib>Arredondo-Valdez, Abril Renee</creatorcontrib><creatorcontrib>Wence-Chávez, Laura Ivonne</creatorcontrib><creatorcontrib>Barros-Núñez, Patricio</creatorcontrib><creatorcontrib>Gallegos-Arreola, Martha P</creatorcontrib><creatorcontrib>Flores-Martínez, Silvia Esperanza</creatorcontrib><creatorcontrib>Sánchez-Corona, Jose</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genetic testing and molecular biomarkers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosales-Reynoso, Mónica Alejandra</au><au>Arredondo-Valdez, Abril Renee</au><au>Wence-Chávez, Laura Ivonne</au><au>Barros-Núñez, Patricio</au><au>Gallegos-Arreola, Martha P</au><au>Flores-Martínez, Silvia Esperanza</au><au>Sánchez-Corona, Jose</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>AXIN2 Polymorphisms and Their Association with Colorectal Cancer in Mexican Patients</atitle><jtitle>Genetic testing and molecular biomarkers</jtitle><addtitle>Genet Test Mol Biomarkers</addtitle><date>2016-08</date><risdate>2016</risdate><volume>20</volume><issue>8</issue><spage>438</spage><epage>444</epage><pages>438-444</pages><issn>1945-0265</issn><eissn>1945-0257</eissn><abstract>The aim of this study was to investigate the association of the rs2240308 and rs1133683 polymorphisms in the AXIN2 gene with colorectal cancer (CRC) in Mexican patients.
Genomic DNAs from 201 CRC patients and 100 healthy blood donors were analyzed for AXIN2 gene polymorphisms by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Statistical associations were calculated using the odds ratio (OR) test.
The genotype distribution of the rs1133683 polymorphism C > T showed a statistical difference between the two study groups (p = 0.0019). Moreover, OR analyses demonstrated that individuals with either the C/T or T/T genotype have a decreased risk for CRC compared with individuals with the C/C genotype (OR = 0.47, 95% confidence interval [CI] = 0.25-0.86, p = 0.0134 and OR = 0.24, 95% CI = 0.10-0.57, p = 0.005, respectively). This association was also evident in a stratified analysis based on tumor-node-metastasis (TNM) stage. For the rs2240308 polymorphism C > T, the OR analysis showed a significantly increased risk for carriers of the T/T genotype (OR = 2.64, 95% CI = 1.12-6.24, p = 0.0236) and this association was also evident in the stratified analysis by TNM stage.
Our results indicate the possibility that variations in the AXIN2 gene may play a significant role in promoting or preventing CRC development.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>27228364</pmid><doi>10.1089/gtmb.2016.0026</doi><tpages>7</tpages></addata></record> |
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| subjects | Adenocarcinoma - epidemiology Adenocarcinoma - genetics Adenocarcinoma - metabolism Adult Alleles Axin Protein - genetics Axin Protein - metabolism Blood donors Cancer Case-Control Studies Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - epidemiology Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Confidence intervals Female Gene Frequency Gene polymorphism Genetic Association Studies Genetic Predisposition to Disease Genotype & phenotype Humans Male Metastases Mexico - epidemiology Middle Aged Patients Polymerase chain reaction Polymorphism Polymorphism, Single Nucleotide Promoter Regions, Genetic Restriction fragment length polymorphism Statistical analysis Statistics |
| title | AXIN2 Polymorphisms and Their Association with Colorectal Cancer in Mexican Patients |
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