Role of UMOD Promoter Polymorphism in the Etiology of Preeclampsia
To evaluate the association between preeclampsia (PE) and the single nucleotide polymorphism (SNP) rs13333226, located in the promoter region of the UMOD gene. A total of 1248 pregnant Han Chinese women (716 controls and 532 patients with PE) were included in this study. Genotyping of the rs13333226...
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| Veröffentlicht in: | Genetic testing and molecular biomarkers 2016-08, Vol.20 (8), p.471-474 |
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| container_title | Genetic testing and molecular biomarkers |
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| creator | Wan, Ji-Peng Li, Lei Li, Hong-Yan Wang, Fei Zhang, Xiao-Jing Zhao, Han Li, Chang-Zhong Wang, Xie-Tong Chen, Zi-Jiang |
| description | To evaluate the association between preeclampsia (PE) and the single nucleotide polymorphism (SNP) rs13333226, located in the promoter region of the UMOD gene.
A total of 1248 pregnant Han Chinese women (716 controls and 532 patients with PE) were included in this study. Genotyping of the rs13333226 polymorphism was performed by real-time PCR using a TaqMan-minor groove binder (MGB) probe assay.
No significant differences were detected in the allele (p = 0.62, OR = 1.08, 95% CI = 0.81-1.44) and genotype frequencies of rs13333226 (padditive = 0.38, pdominant = 0.45, precessive = 0.31) between cases and controls. When patients were divided into subgroups, no association was found with mild preeclampsia (M PE), severe preeclampsia (S PE), early onset PE, or late-onset PE. Furthermore, no significant differences were detected in the genotype and allele frequencies of rs1333226 between patients with M PE and S PE (p > 0.05) or between patients with late and early onset of the disease (p > 0.05).
UMOD rs13333226 does not appear to be associated with PE in Han Chinese women. |
| doi_str_mv | 10.1089/gtmb.2015.0268 |
| format | Article |
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A total of 1248 pregnant Han Chinese women (716 controls and 532 patients with PE) were included in this study. Genotyping of the rs13333226 polymorphism was performed by real-time PCR using a TaqMan-minor groove binder (MGB) probe assay.
No significant differences were detected in the allele (p = 0.62, OR = 1.08, 95% CI = 0.81-1.44) and genotype frequencies of rs13333226 (padditive = 0.38, pdominant = 0.45, precessive = 0.31) between cases and controls. When patients were divided into subgroups, no association was found with mild preeclampsia (M PE), severe preeclampsia (S PE), early onset PE, or late-onset PE. Furthermore, no significant differences were detected in the genotype and allele frequencies of rs1333226 between patients with M PE and S PE (p > 0.05) or between patients with late and early onset of the disease (p > 0.05).
UMOD rs13333226 does not appear to be associated with PE in Han Chinese women.</description><identifier>ISSN: 1945-0265</identifier><identifier>EISSN: 1945-0257</identifier><identifier>DOI: 10.1089/gtmb.2015.0268</identifier><identifier>PMID: 27315129</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Alleles ; Asian Continental Ancestry Group - genetics ; Borides ; Case-Control Studies ; China ; Ethnic Groups - genetics ; Etiology ; Female ; Gene Frequency ; Gene polymorphism ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotyping ; Humans ; Patients ; Polymorphism ; Polymorphism, Single Nucleotide ; Pre-eclampsia ; Pre-Eclampsia - genetics ; Preeclampsia ; Pregnancy ; Promoter Regions, Genetic ; Single-nucleotide polymorphism ; Subgroups ; Uromodulin - genetics</subject><ispartof>Genetic testing and molecular biomarkers, 2016-08, Vol.20 (8), p.471-474</ispartof><rights>Copyright Mary Ann Liebert, Inc. Aug 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-a79fbbf76e6b62e0f23c32816bb37cd152cea1f434e2622c22014906b2c872f43</citedby><cites>FETCH-LOGICAL-c356t-a79fbbf76e6b62e0f23c32816bb37cd152cea1f434e2622c22014906b2c872f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27315129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wan, Ji-Peng</creatorcontrib><creatorcontrib>Li, Lei</creatorcontrib><creatorcontrib>Li, Hong-Yan</creatorcontrib><creatorcontrib>Wang, Fei</creatorcontrib><creatorcontrib>Zhang, Xiao-Jing</creatorcontrib><creatorcontrib>Zhao, Han</creatorcontrib><creatorcontrib>Li, Chang-Zhong</creatorcontrib><creatorcontrib>Wang, Xie-Tong</creatorcontrib><creatorcontrib>Chen, Zi-Jiang</creatorcontrib><title>Role of UMOD Promoter Polymorphism in the Etiology of Preeclampsia</title><title>Genetic testing and molecular biomarkers</title><addtitle>Genet Test Mol Biomarkers</addtitle><description>To evaluate the association between preeclampsia (PE) and the single nucleotide polymorphism (SNP) rs13333226, located in the promoter region of the UMOD gene.
A total of 1248 pregnant Han Chinese women (716 controls and 532 patients with PE) were included in this study. Genotyping of the rs13333226 polymorphism was performed by real-time PCR using a TaqMan-minor groove binder (MGB) probe assay.
No significant differences were detected in the allele (p = 0.62, OR = 1.08, 95% CI = 0.81-1.44) and genotype frequencies of rs13333226 (padditive = 0.38, pdominant = 0.45, precessive = 0.31) between cases and controls. When patients were divided into subgroups, no association was found with mild preeclampsia (M PE), severe preeclampsia (S PE), early onset PE, or late-onset PE. Furthermore, no significant differences were detected in the genotype and allele frequencies of rs1333226 between patients with M PE and S PE (p > 0.05) or between patients with late and early onset of the disease (p > 0.05).
UMOD rs13333226 does not appear to be associated with PE in Han Chinese women.</description><subject>Alleles</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Borides</subject><subject>Case-Control Studies</subject><subject>China</subject><subject>Ethnic Groups - genetics</subject><subject>Etiology</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotyping</subject><subject>Humans</subject><subject>Patients</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Pre-eclampsia</subject><subject>Pre-Eclampsia - genetics</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Promoter Regions, Genetic</subject><subject>Single-nucleotide polymorphism</subject><subject>Subgroups</subject><subject>Uromodulin - genetics</subject><issn>1945-0265</issn><issn>1945-0257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkb1PwzAQxS0EolBYGVEkFpYU-xx_ZIRSPqSiVojOVuI6baq4DnYy9L8nUUsHJqY7nX73pPceQjcEjwiW6cOqsfkIMGEjDFyeoAuSJizGwMTpcedsgC5D2GDMEyr5ORqAoIQRSC_Q06erTOSKaPExe47m3lnXGB_NXbWzztfrMtio3EbN2kSTpnSVW-16eu6N0VVm61BmV-isyKpgrg9ziBYvk6_xWzydvb6PH6expow3cSbSIs8LwQ3PORhcANUUJOF5ToVeEgbaZKRIaGKAA2joXCUp5jloKaC7D9H9Xrf27rs1oVG2DNpUVbY1rg2KSBBSQsrYP9AuPC6AyQ69-4NuXOu3nREFhDKBcQo9NdpT2rsQvClU7Uub-Z0iWPVFqL4I1Reh-iK6h9uDbJtbszziv8nTH8f-gYI</recordid><startdate>201608</startdate><enddate>201608</enddate><creator>Wan, Ji-Peng</creator><creator>Li, Lei</creator><creator>Li, Hong-Yan</creator><creator>Wang, Fei</creator><creator>Zhang, Xiao-Jing</creator><creator>Zhao, Han</creator><creator>Li, Chang-Zhong</creator><creator>Wang, Xie-Tong</creator><creator>Chen, Zi-Jiang</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201608</creationdate><title>Role of UMOD Promoter Polymorphism in the Etiology of Preeclampsia</title><author>Wan, Ji-Peng ; Li, Lei ; Li, Hong-Yan ; Wang, Fei ; Zhang, Xiao-Jing ; Zhao, Han ; Li, Chang-Zhong ; Wang, Xie-Tong ; Chen, Zi-Jiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-a79fbbf76e6b62e0f23c32816bb37cd152cea1f434e2622c22014906b2c872f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Alleles</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Borides</topic><topic>Case-Control Studies</topic><topic>China</topic><topic>Ethnic Groups - genetics</topic><topic>Etiology</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Gene polymorphism</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotyping</topic><topic>Humans</topic><topic>Patients</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Pre-eclampsia</topic><topic>Pre-Eclampsia - genetics</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Promoter Regions, Genetic</topic><topic>Single-nucleotide polymorphism</topic><topic>Subgroups</topic><topic>Uromodulin - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wan, Ji-Peng</creatorcontrib><creatorcontrib>Li, Lei</creatorcontrib><creatorcontrib>Li, Hong-Yan</creatorcontrib><creatorcontrib>Wang, Fei</creatorcontrib><creatorcontrib>Zhang, Xiao-Jing</creatorcontrib><creatorcontrib>Zhao, Han</creatorcontrib><creatorcontrib>Li, Chang-Zhong</creatorcontrib><creatorcontrib>Wang, Xie-Tong</creatorcontrib><creatorcontrib>Chen, Zi-Jiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genetic testing and molecular biomarkers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wan, Ji-Peng</au><au>Li, Lei</au><au>Li, Hong-Yan</au><au>Wang, Fei</au><au>Zhang, Xiao-Jing</au><au>Zhao, Han</au><au>Li, Chang-Zhong</au><au>Wang, Xie-Tong</au><au>Chen, Zi-Jiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of UMOD Promoter Polymorphism in the Etiology of Preeclampsia</atitle><jtitle>Genetic testing and molecular biomarkers</jtitle><addtitle>Genet Test Mol Biomarkers</addtitle><date>2016-08</date><risdate>2016</risdate><volume>20</volume><issue>8</issue><spage>471</spage><epage>474</epage><pages>471-474</pages><issn>1945-0265</issn><eissn>1945-0257</eissn><abstract>To evaluate the association between preeclampsia (PE) and the single nucleotide polymorphism (SNP) rs13333226, located in the promoter region of the UMOD gene.
A total of 1248 pregnant Han Chinese women (716 controls and 532 patients with PE) were included in this study. Genotyping of the rs13333226 polymorphism was performed by real-time PCR using a TaqMan-minor groove binder (MGB) probe assay.
No significant differences were detected in the allele (p = 0.62, OR = 1.08, 95% CI = 0.81-1.44) and genotype frequencies of rs13333226 (padditive = 0.38, pdominant = 0.45, precessive = 0.31) between cases and controls. When patients were divided into subgroups, no association was found with mild preeclampsia (M PE), severe preeclampsia (S PE), early onset PE, or late-onset PE. Furthermore, no significant differences were detected in the genotype and allele frequencies of rs1333226 between patients with M PE and S PE (p > 0.05) or between patients with late and early onset of the disease (p > 0.05).
UMOD rs13333226 does not appear to be associated with PE in Han Chinese women.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>27315129</pmid><doi>10.1089/gtmb.2015.0268</doi><tpages>4</tpages></addata></record> |
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| subjects | Alleles Asian Continental Ancestry Group - genetics Borides Case-Control Studies China Ethnic Groups - genetics Etiology Female Gene Frequency Gene polymorphism Genetic Association Studies Genetic Predisposition to Disease Genotyping Humans Patients Polymorphism Polymorphism, Single Nucleotide Pre-eclampsia Pre-Eclampsia - genetics Preeclampsia Pregnancy Promoter Regions, Genetic Single-nucleotide polymorphism Subgroups Uromodulin - genetics |
| title | Role of UMOD Promoter Polymorphism in the Etiology of Preeclampsia |
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