Imaging of cerebral α 4 β 2 nicotinic acetylcholine receptors with (−)-[ 18 F]Flubatine PET: Implementation of bolus plus constant infusion and sensitivity to acetylcholine in human brain

The positron emission tomography (PET) radioligand (−)-[18F]flubatine is specific to α4β2⁎ nicotinic acetylcholine receptors (nAChRs) and has promise for future investigation of the acetylcholine system in neuropathologies such as Alzheimer's disease, schizophrenia, and substance use disorders....

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2016-11, Vol.141, p.71-80
Hauptverfasser:	Hillmer, A T, Esterlis, I, Gallezot, J D, Bois, F, Zheng, M Q, Nabulsi, N, Lin, S F, Papke, R L, Huang, Y, Sabri, O, Carson, R E, Cosgrove, K P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (nicotinic) Alzheimer's disease Binding sites Cerebellum Cortex Data processing Equilibrium Experiments Human subjects Injection Mental disorders Neurodegenerative diseases Neuroimaging Physostigmine Positron emission tomography Schizophrenia Studies Substantia grisea Thalamus
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