Induction of mucosal IgA following intravaginal administration of inactivated HIV-1-capturing nanospheres in mice

Concanavalin A‐immobilized polystyrene nanospheres (Con A‐NS) were developed for the HIV‐1 vaccine capable of preventing sexual transmission. Con A‐NS could capture efficiently HIV‐1 irrespective of their cell tropism (R5 or X4). Furthermore, Con A‐NS captured equally infectious and heat‐inactivated...

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