Biological Activity Studies of Ancistrocladus tectorius
Methanol (ATRM) and chloroform (alkaloidal) extracts (ATRC) from the roots of Ancistrocladus tectorius Merr. were used for in vitro biological tests including antibacterial (eleven species or isolates), antiviral (HSV type 1), antiparasitic (Giardia lamblia), effects on the phagocytic and cytotoxic...
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| Veröffentlicht in: | Pharmaceutical biology 2001, Vol.39 (5), p.357-363 |
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| container_title | Pharmaceutical biology |
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| creator | Said, Ikram M. Ahmad, I.B. Yahya, M.D. Marini, A.M. |
| description | Methanol (ATRM) and chloroform (alkaloidal) extracts (ATRC) from the roots of Ancistrocladus tectorius Merr. were used for in vitro biological tests including antibacterial (eleven species or isolates), antiviral (HSV type 1), antiparasitic (Giardia lamblia), effects on the phagocytic and cytotoxic functions of murine macrophages as well as toxicities toward brine shrimp and cell cultures (nine types). The antibacterial, antiviral and toxic activities were moderate, while anti-giardial activity was not observed. Phagocytosis and intracellular killing of Listeria monocytogenes was increased by both extracts. However, antibody-dependent cell-mediated cytotoxicity (ADCC) of antibody-opsonised sheep red blood cells was increased by the methanol extract but inhibited by the chloroform extract. |
| doi_str_mv | 10.1076/phbi.39.5.357.5897 |
| format | Article |
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The antibacterial, antiviral and toxic activities were moderate, while anti-giardial activity was not observed. Phagocytosis and intracellular killing of Listeria monocytogenes was increased by both extracts. However, antibody-dependent cell-mediated cytotoxicity (ADCC) of antibody-opsonised sheep red blood cells was increased by the methanol extract but inhibited by the chloroform extract.</description><identifier>ISSN: 1388-0209</identifier><identifier>EISSN: 1744-5116</identifier><identifier>DOI: 10.1076/phbi.39.5.357.5897</identifier><language>eng</language><publisher>Lisse: Informa UK Ltd</publisher><subject>Ancistrocladus tectorius ; Biological and medical sciences ; General pharmacology ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. 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The antibacterial, antiviral and toxic activities were moderate, while anti-giardial activity was not observed. Phagocytosis and intracellular killing of Listeria monocytogenes was increased by both extracts. However, antibody-dependent cell-mediated cytotoxicity (ADCC) of antibody-opsonised sheep red blood cells was increased by the methanol extract but inhibited by the chloroform extract.</description><subject>Ancistrocladus tectorius</subject><subject>Biological and medical sciences</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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The antibacterial, antiviral and toxic activities were moderate, while anti-giardial activity was not observed. Phagocytosis and intracellular killing of Listeria monocytogenes was increased by both extracts. However, antibody-dependent cell-mediated cytotoxicity (ADCC) of antibody-opsonised sheep red blood cells was increased by the methanol extract but inhibited by the chloroform extract.</abstract><cop>Lisse</cop><pub>Informa UK Ltd</pub><doi>10.1076/phbi.39.5.357.5897</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1388-0209 |
| ispartof | Pharmaceutical biology, 2001, Vol.39 (5), p.357-363 |
| issn | 1388-0209 1744-5116 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_18270422 |
| source | Taylor & Francis; Alma/SFX Local Collection |
| subjects | Ancistrocladus tectorius Biological and medical sciences General pharmacology Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments |
| title | Biological Activity Studies of Ancistrocladus tectorius |
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