Calcium Phosphates and Angiogenesis: Implications and Advances for Bone Regeneration
Calcium phosphates (CaPs) are among the most utilized synthetic biomaterials for bone regeneration, largely owing to their established osteoconductive and osteoinductive properties. While angiogenesis is a crucial prerequisite to bone formation, research and applications for CaPs have not appreciate...
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| Veröffentlicht in: | Trends in biotechnology (Regular ed.) 2016-12, Vol.34 (12), p.983-992 |
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| creator | Malhotra, Angad Habibovic, Pamela |
| description | Calcium phosphates (CaPs) are among the most utilized synthetic biomaterials for bone regeneration, largely owing to their established osteoconductive and osteoinductive properties. While angiogenesis is a crucial prerequisite to bone formation, research and applications for CaPs have not appreciated its crucial role. This review discusses how CaPs influence angiogenesis, and highlights promising strategies that address this topic. The objective is to draw attention to the gap in the literature and to highlight the importance of angiogenesis in CaP research, development, and use. |
| doi_str_mv | 10.1016/j.tibtech.2016.07.005 |
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While angiogenesis is a crucial prerequisite to bone formation, research and applications for CaPs have not appreciated its crucial role. This review discusses how CaPs influence angiogenesis, and highlights promising strategies that address this topic. The objective is to draw attention to the gap in the literature and to highlight the importance of angiogenesis in CaP research, development, and use.</description><subject>Angiogenesis</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Biomaterials</subject><subject>Bone Regeneration - physiology</subject><subject>Calcium</subject><subject>Calcium Phosphates</subject><subject>Gene expression</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Influence</subject><subject>Internal Medicine</subject><subject>Mechanical properties</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Mesenchymal Stromal Cells - physiology</subject><subject>Mice</subject><subject>Neovascularization, Physiologic</subject><subject>R&D</subject><subject>Research & development</subject><subject>Studies</subject><subject>Tissue engineering</subject><subject>Tissue Engineering - methods</subject><subject>Tissue Engineering - 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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Angiogenesis Animals Apoptosis Biomaterials Bone Regeneration - physiology Calcium Calcium Phosphates Gene expression Growth factors Humans Influence Internal Medicine Mechanical properties Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - physiology Mice Neovascularization, Physiologic R&D Research & development Studies Tissue engineering Tissue Engineering - methods Tissue Engineering - trends |
| title | Calcium Phosphates and Angiogenesis: Implications and Advances for Bone Regeneration |
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