Comparison of glycosaminoglycan chemical exchange saturation transfer using Gaussian‐shaped and off‐resonant spin‐lock radiofrequency pulses in intervertebral disks
Purpose To investigate, if a train of spin‐lock pulses (chemical exchange saturation transfer with spin‐lock pulses = CESL) improves biochemical glycosaminoglycan imaging compared with conventional chemical exchange saturation transfer with Gaussian‐shaped pulses (CEST) in lumbar intervertebral disc...
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| Veröffentlicht in: | Magnetic resonance in medicine 2017-07, Vol.78 (1), p.280-284 |
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| creator | Müller‐Lutz, Anja Cronenberg, Tom Schleich, Christoph Wickrath, Frithjof Zaiss, Moritz Boos, Johannes Wittsack, Hans‐Jörg |
| description | Purpose
To investigate, if a train of spin‐lock pulses (chemical exchange saturation transfer with spin‐lock pulses = CESL) improves biochemical glycosaminoglycan imaging compared with conventional chemical exchange saturation transfer with Gaussian‐shaped pulses (CEST) in lumbar intervertebral discs.
Methods
T2, CEST, and CESL imaging was performed in lumbar intervertebral discs of 15 healthy volunteers at 3 Tesla. Mean and standard deviation of the asymmetric magnetization transfer ratio (MTRasym), the asymmetric spin‐lock ratio (SLRasym) and T2 values were calculated for nucleus pulposus (NP) and annulus fibrosus (AF). Wilcoxon test was used to analyze differences between MTRasym and SLRasym. Pearson correlation was used to determine the relationship between MTRasym, SLRasym and T2.
Results
Data showed no significant difference between MTRasym and SLRasym (NP: P = 0.35; AF: P = 0.34). MTRasym and SLRasym values differed significantly between NP and AF (MTRasym: P = 0.014, SLRasym: P = 0.005). T2 values correlated significantly with MTRasym (NP: ρ = 0.76, P |
| doi_str_mv | 10.1002/mrm.26362 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1826739455</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1826739455</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3882-536b17efe673a679b83a14b8d3cfffb6e95c9d86a79dbee71aa6e489ed3944863</originalsourceid><addsrcrecordid>eNp1kc-KFDEQh4Mo7rh68AUk4EUPs5t_ne4cZdBV2EUQPTfV6cpMdruTNulenZuP4HP4WD6JGWf1IAiBCsVXXxX8CHnK2RlnTJyPaTwTWmpxj6x4JcRaVEbdJytWK7aW3KgT8ijna8aYMbV6SE5ErRqltFmRH5s4TpB8joFGR7fD3sYMow_x8IVA7Q5Hb2Gg-NXuIGyRZpiXBLMvE3OCkB0mumQftvQClpw9hJ_fvucdTNhTCH3RutJIWFZAmGme_AEYor2hCXofXcLPCwa7p9MyZMzUh_JmTLeYZuxS2d37fJMfkwcOCvDkrp6ST29ef9y8XV--v3i3eXW5trJpxLqSuuM1OtS1BF2brpHAVdf00jrnOo2msqZvNNSm7xBrDqBRNQZ7aZRqtDwlL47eKcVyWJ7b0WeLwwAB45Jb3oiiNqqqCvr8H_Q6LimU61puOKuF1JwV6uWRsinmnNC1U_IjpH3LWXsIsC0Btr8DLOyzO-PSjdj_Jf8kVoDzI_DFD7j_v6m9-nB1VP4CZcWteQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1910723610</pqid></control><display><type>article</type><title>Comparison of glycosaminoglycan chemical exchange saturation transfer using Gaussian‐shaped and off‐resonant spin‐lock radiofrequency pulses in intervertebral disks</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Free Content</source><creator>Müller‐Lutz, Anja ; Cronenberg, Tom ; Schleich, Christoph ; Wickrath, Frithjof ; Zaiss, Moritz ; Boos, Johannes ; Wittsack, Hans‐Jörg</creator><creatorcontrib>Müller‐Lutz, Anja ; Cronenberg, Tom ; Schleich, Christoph ; Wickrath, Frithjof ; Zaiss, Moritz ; Boos, Johannes ; Wittsack, Hans‐Jörg</creatorcontrib><description>Purpose
To investigate, if a train of spin‐lock pulses (chemical exchange saturation transfer with spin‐lock pulses = CESL) improves biochemical glycosaminoglycan imaging compared with conventional chemical exchange saturation transfer with Gaussian‐shaped pulses (CEST) in lumbar intervertebral discs.
Methods
T2, CEST, and CESL imaging was performed in lumbar intervertebral discs of 15 healthy volunteers at 3 Tesla. Mean and standard deviation of the asymmetric magnetization transfer ratio (MTRasym), the asymmetric spin‐lock ratio (SLRasym) and T2 values were calculated for nucleus pulposus (NP) and annulus fibrosus (AF). Wilcoxon test was used to analyze differences between MTRasym and SLRasym. Pearson correlation was used to determine the relationship between MTRasym, SLRasym and T2.
Results
Data showed no significant difference between MTRasym and SLRasym (NP: P = 0.35; AF: P = 0.34). MTRasym and SLRasym values differed significantly between NP and AF (MTRasym: P = 0.014, SLRasym: P = 0.005). T2 values correlated significantly with MTRasym (NP: ρ = 0.76, P < 0.001; AF: ρ = 0.60, P < 0.001) and SLRasym (NP: ρ = 0.73, P < 0.001; AF: ρ = 0.47, P < 0.001).
Conclusion
CESL does not improve the chemical exchange asymmetry effect compared with conventional CEST, but leads to comparable results. Magn Reson Med 78:280–284, 2017. © 2016 International Society for Magnetic Resonance in Medicine</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.26362</identifier><identifier>PMID: 27484469</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Asymmetry ; Biochemistry ; chemical exchange saturation transfer ; Computer Simulation ; Correlation analysis ; Data Interpretation, Statistical ; Exchanging ; glycosaminoglycans ; Glycosaminoglycans - metabolism ; Humans ; Image Enhancement - methods ; Image Interpretation, Computer-Assisted - methods ; Imaging ; Intervertebral Disc - diagnostic imaging ; Intervertebral Disc - metabolism ; Intervertebral discs ; intervertebral disks ; Magma ; Magnetic resonance ; Magnetic Resonance Imaging - methods ; Magnetization ; Mathematical analysis ; Medicine ; Middle Aged ; Models, Statistical ; Molecular Imaging - methods ; Normal Distribution ; Nuclei ; Nucleus pulposus ; Radio frequency ; Radio Waves ; Reproducibility of Results ; Resonance ; Saturation ; Sensitivity and Specificity ; Signal Processing, Computer-Assisted ; Spin Labels ; spin‐lock ; Standard deviation ; Young Adult</subject><ispartof>Magnetic resonance in medicine, 2017-07, Vol.78 (1), p.280-284</ispartof><rights>2016 International Society for Magnetic Resonance in Medicine.</rights><rights>2017 International Society for Magnetic Resonance in Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3882-536b17efe673a679b83a14b8d3cfffb6e95c9d86a79dbee71aa6e489ed3944863</citedby><cites>FETCH-LOGICAL-c3882-536b17efe673a679b83a14b8d3cfffb6e95c9d86a79dbee71aa6e489ed3944863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.26362$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.26362$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27484469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Müller‐Lutz, Anja</creatorcontrib><creatorcontrib>Cronenberg, Tom</creatorcontrib><creatorcontrib>Schleich, Christoph</creatorcontrib><creatorcontrib>Wickrath, Frithjof</creatorcontrib><creatorcontrib>Zaiss, Moritz</creatorcontrib><creatorcontrib>Boos, Johannes</creatorcontrib><creatorcontrib>Wittsack, Hans‐Jörg</creatorcontrib><title>Comparison of glycosaminoglycan chemical exchange saturation transfer using Gaussian‐shaped and off‐resonant spin‐lock radiofrequency pulses in intervertebral disks</title><title>Magnetic resonance in medicine</title><addtitle>Magn Reson Med</addtitle><description>Purpose
To investigate, if a train of spin‐lock pulses (chemical exchange saturation transfer with spin‐lock pulses = CESL) improves biochemical glycosaminoglycan imaging compared with conventional chemical exchange saturation transfer with Gaussian‐shaped pulses (CEST) in lumbar intervertebral discs.
Methods
T2, CEST, and CESL imaging was performed in lumbar intervertebral discs of 15 healthy volunteers at 3 Tesla. Mean and standard deviation of the asymmetric magnetization transfer ratio (MTRasym), the asymmetric spin‐lock ratio (SLRasym) and T2 values were calculated for nucleus pulposus (NP) and annulus fibrosus (AF). Wilcoxon test was used to analyze differences between MTRasym and SLRasym. Pearson correlation was used to determine the relationship between MTRasym, SLRasym and T2.
Results
Data showed no significant difference between MTRasym and SLRasym (NP: P = 0.35; AF: P = 0.34). MTRasym and SLRasym values differed significantly between NP and AF (MTRasym: P = 0.014, SLRasym: P = 0.005). T2 values correlated significantly with MTRasym (NP: ρ = 0.76, P < 0.001; AF: ρ = 0.60, P < 0.001) and SLRasym (NP: ρ = 0.73, P < 0.001; AF: ρ = 0.47, P < 0.001).
Conclusion
CESL does not improve the chemical exchange asymmetry effect compared with conventional CEST, but leads to comparable results. Magn Reson Med 78:280–284, 2017. © 2016 International Society for Magnetic Resonance in Medicine</description><subject>Adult</subject><subject>Asymmetry</subject><subject>Biochemistry</subject><subject>chemical exchange saturation transfer</subject><subject>Computer Simulation</subject><subject>Correlation analysis</subject><subject>Data Interpretation, Statistical</subject><subject>Exchanging</subject><subject>glycosaminoglycans</subject><subject>Glycosaminoglycans - metabolism</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Imaging</subject><subject>Intervertebral Disc - diagnostic imaging</subject><subject>Intervertebral Disc - metabolism</subject><subject>Intervertebral discs</subject><subject>intervertebral disks</subject><subject>Magma</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetization</subject><subject>Mathematical analysis</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Models, Statistical</subject><subject>Molecular Imaging - methods</subject><subject>Normal Distribution</subject><subject>Nuclei</subject><subject>Nucleus pulposus</subject><subject>Radio frequency</subject><subject>Radio Waves</subject><subject>Reproducibility of Results</subject><subject>Resonance</subject><subject>Saturation</subject><subject>Sensitivity and Specificity</subject><subject>Signal Processing, Computer-Assisted</subject><subject>Spin Labels</subject><subject>spin‐lock</subject><subject>Standard deviation</subject><subject>Young Adult</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc-KFDEQh4Mo7rh68AUk4EUPs5t_ne4cZdBV2EUQPTfV6cpMdruTNulenZuP4HP4WD6JGWf1IAiBCsVXXxX8CHnK2RlnTJyPaTwTWmpxj6x4JcRaVEbdJytWK7aW3KgT8ijna8aYMbV6SE5ErRqltFmRH5s4TpB8joFGR7fD3sYMow_x8IVA7Q5Hb2Gg-NXuIGyRZpiXBLMvE3OCkB0mumQftvQClpw9hJ_fvucdTNhTCH3RutJIWFZAmGme_AEYor2hCXofXcLPCwa7p9MyZMzUh_JmTLeYZuxS2d37fJMfkwcOCvDkrp6ST29ef9y8XV--v3i3eXW5trJpxLqSuuM1OtS1BF2brpHAVdf00jrnOo2msqZvNNSm7xBrDqBRNQZ7aZRqtDwlL47eKcVyWJ7b0WeLwwAB45Jb3oiiNqqqCvr8H_Q6LimU61puOKuF1JwV6uWRsinmnNC1U_IjpH3LWXsIsC0Btr8DLOyzO-PSjdj_Jf8kVoDzI_DFD7j_v6m9-nB1VP4CZcWteQ</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Müller‐Lutz, Anja</creator><creator>Cronenberg, Tom</creator><creator>Schleich, Christoph</creator><creator>Wickrath, Frithjof</creator><creator>Zaiss, Moritz</creator><creator>Boos, Johannes</creator><creator>Wittsack, Hans‐Jörg</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201707</creationdate><title>Comparison of glycosaminoglycan chemical exchange saturation transfer using Gaussian‐shaped and off‐resonant spin‐lock radiofrequency pulses in intervertebral disks</title><author>Müller‐Lutz, Anja ; Cronenberg, Tom ; Schleich, Christoph ; Wickrath, Frithjof ; Zaiss, Moritz ; Boos, Johannes ; Wittsack, Hans‐Jörg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3882-536b17efe673a679b83a14b8d3cfffb6e95c9d86a79dbee71aa6e489ed3944863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Asymmetry</topic><topic>Biochemistry</topic><topic>chemical exchange saturation transfer</topic><topic>Computer Simulation</topic><topic>Correlation analysis</topic><topic>Data Interpretation, Statistical</topic><topic>Exchanging</topic><topic>glycosaminoglycans</topic><topic>Glycosaminoglycans - metabolism</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Imaging</topic><topic>Intervertebral Disc - diagnostic imaging</topic><topic>Intervertebral Disc - metabolism</topic><topic>Intervertebral discs</topic><topic>intervertebral disks</topic><topic>Magma</topic><topic>Magnetic resonance</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetization</topic><topic>Mathematical analysis</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Models, Statistical</topic><topic>Molecular Imaging - methods</topic><topic>Normal Distribution</topic><topic>Nuclei</topic><topic>Nucleus pulposus</topic><topic>Radio frequency</topic><topic>Radio Waves</topic><topic>Reproducibility of Results</topic><topic>Resonance</topic><topic>Saturation</topic><topic>Sensitivity and Specificity</topic><topic>Signal Processing, Computer-Assisted</topic><topic>Spin Labels</topic><topic>spin‐lock</topic><topic>Standard deviation</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Müller‐Lutz, Anja</creatorcontrib><creatorcontrib>Cronenberg, Tom</creatorcontrib><creatorcontrib>Schleich, Christoph</creatorcontrib><creatorcontrib>Wickrath, Frithjof</creatorcontrib><creatorcontrib>Zaiss, Moritz</creatorcontrib><creatorcontrib>Boos, Johannes</creatorcontrib><creatorcontrib>Wittsack, Hans‐Jörg</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Müller‐Lutz, Anja</au><au>Cronenberg, Tom</au><au>Schleich, Christoph</au><au>Wickrath, Frithjof</au><au>Zaiss, Moritz</au><au>Boos, Johannes</au><au>Wittsack, Hans‐Jörg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of glycosaminoglycan chemical exchange saturation transfer using Gaussian‐shaped and off‐resonant spin‐lock radiofrequency pulses in intervertebral disks</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn Reson Med</addtitle><date>2017-07</date><risdate>2017</risdate><volume>78</volume><issue>1</issue><spage>280</spage><epage>284</epage><pages>280-284</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><abstract>Purpose
To investigate, if a train of spin‐lock pulses (chemical exchange saturation transfer with spin‐lock pulses = CESL) improves biochemical glycosaminoglycan imaging compared with conventional chemical exchange saturation transfer with Gaussian‐shaped pulses (CEST) in lumbar intervertebral discs.
Methods
T2, CEST, and CESL imaging was performed in lumbar intervertebral discs of 15 healthy volunteers at 3 Tesla. Mean and standard deviation of the asymmetric magnetization transfer ratio (MTRasym), the asymmetric spin‐lock ratio (SLRasym) and T2 values were calculated for nucleus pulposus (NP) and annulus fibrosus (AF). Wilcoxon test was used to analyze differences between MTRasym and SLRasym. Pearson correlation was used to determine the relationship between MTRasym, SLRasym and T2.
Results
Data showed no significant difference between MTRasym and SLRasym (NP: P = 0.35; AF: P = 0.34). MTRasym and SLRasym values differed significantly between NP and AF (MTRasym: P = 0.014, SLRasym: P = 0.005). T2 values correlated significantly with MTRasym (NP: ρ = 0.76, P < 0.001; AF: ρ = 0.60, P < 0.001) and SLRasym (NP: ρ = 0.73, P < 0.001; AF: ρ = 0.47, P < 0.001).
Conclusion
CESL does not improve the chemical exchange asymmetry effect compared with conventional CEST, but leads to comparable results. Magn Reson Med 78:280–284, 2017. © 2016 International Society for Magnetic Resonance in Medicine</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27484469</pmid><doi>10.1002/mrm.26362</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Asymmetry Biochemistry chemical exchange saturation transfer Computer Simulation Correlation analysis Data Interpretation, Statistical Exchanging glycosaminoglycans Glycosaminoglycans - metabolism Humans Image Enhancement - methods Image Interpretation, Computer-Assisted - methods Imaging Intervertebral Disc - diagnostic imaging Intervertebral Disc - metabolism Intervertebral discs intervertebral disks Magma Magnetic resonance Magnetic Resonance Imaging - methods Magnetization Mathematical analysis Medicine Middle Aged Models, Statistical Molecular Imaging - methods Normal Distribution Nuclei Nucleus pulposus Radio frequency Radio Waves Reproducibility of Results Resonance Saturation Sensitivity and Specificity Signal Processing, Computer-Assisted Spin Labels spin‐lock Standard deviation Young Adult |
| title | Comparison of glycosaminoglycan chemical exchange saturation transfer using Gaussian‐shaped and off‐resonant spin‐lock radiofrequency pulses in intervertebral disks |
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