What We Observe In Vivo Is Not Always What We See In Vitro: Development and Validation of 11C-JNJ-42491293, A Novel Radioligand for mGluR2

Positive allosteric modulators (PAM) of metabotropic glutamate receptor 2 (mGluR2) are a potential therapy for anxiety, schizophrenia, and addiction. Aside from pathophysiologic imaging studies, an mGluR2 PET tracer would enable confirmation of sufficient central target engagement and assist dose se...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2017-01, Vol.58 (1), p.110-116
Hauptverfasser:	Leurquin-Sterk, Gil, Celen, Sofie, Van Laere, Koen, Koole, Michel, Bormans, Guy, Langlois, Xavier, Van Hecken, Anne, Te Riele, Paula, Alcázar, Jesús, Verbruggen, Alfons, de Hoon, Jan, Andrés, Jose-Ignacio, Schmidt, Mark E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Brain - diagnostic imaging Brain - metabolism Carbon Radioisotopes - pharmacokinetics Excitatory Amino Acid Antagonists - pharmacokinetics Humans Isotope Labeling Male Metabolic Clearance Rate Molecular Imaging - methods Organ Specificity Positron-Emission Tomography - methods Radiopharmaceuticals - pharmacokinetics Rats Rats, Wistar Receptors, Metabotropic Glutamate - metabolism Reproducibility of Results Sensitivity and Specificity Tissue Distribution Young Adult
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