Single cell analysis revealed a coexistence of NOTCH1 and TP53 mutations within the same cancer cells in chronic lymphocytic leukaemia patients

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Veröffentlicht in:	British journal of haematology 2017-09, Vol.178 (6), p.979-982
Hauptverfasser:	Kantorova, Barbara, Malcikova, Jitka, Brazdilova, Kamila, Borsky, Marek, Plevova, Karla, Smardova, Jana, Radova, Lenka, Tom, Nikola, Trbusek, Martin, Diviskova, Eva, Francova, Hana Skuhrova, Navrkalova, Veronika, Doubek, Michael, Brychtova, Yvona, Mayer, Jiri, Pospisilova, Sarka
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Cancer Chronic lymphocytic leukemia CLL clonal evolution Clonal Evolution - genetics DNA Mutational Analysis - methods Genotype Hematology Humans Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - genetics NOTCH1 mutation Notch1 protein p53 Protein Receptor, Notch1 - genetics single cell analysis Single-Cell Analysis - methods TP53 mutations Tumor Suppressor Protein p53 - genetics
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