Insights into the cytotoxic activity of the phosphane copper(I) complex [Cu(thp)4][PF6]

The phosphane Cu(I) complex [Cu(thp)4][PF6], 1 (thp=tris(hydroxymethyl)phosphane) shows notable in vitro antitumour activity against a wide range of solid tumours. Uptake experiments performed in 1-treated colon cancer cells by atomic absorption spectrometry, reveal that the antiproliferative activi...

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Veröffentlicht in:	Journal of inorganic biochemistry 2016-12, Vol.165, p.80-91
Hauptverfasser:	Tisato, Francesco, Marzano, Cristina, Peruzzo, Valentina, Tegoni, Matteo, Giorgetti, Marco, Damjanovic, Marko, Trapananti, Angela, Bagno, Alessandro, Santini, Carlo, Pellei, Maura, Porchia, Marina, Gandin, Valentina
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumour activity Caco-2 Cells Chelating Agents - chemistry Chelating Agents - pharmacology Complex lability Copper - chemistry Copper - pharmacology Cytotoxins - chemistry Cytotoxins - pharmacology HeLa Cells Hep G2 Cells Humans MCF-7 Cells Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Phosphane copper(I) complexes Phosphorus Compounds - chemistry Phosphorus Compounds - pharmacology
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