Computational study for the effects of coil configuration on blood flow characteristics in coil-embolized cerebral aneurysm
Coil embolization of cerebral aneurysms with inhomogeneous coil distribution leads to an incomplete occlusion of the aneurysm. However, the effects of this factor on the blood flow characteristics are still not fully understood. This study investigates the effects of coil configuration on the blood...
Gespeichert in:
| Veröffentlicht in: | Medical & biological engineering & computing 2017-05, Vol.55 (5), p.697-710 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 710 |
|---|---|
| container_issue | 5 |
| container_start_page | 697 |
| container_title | Medical & biological engineering & computing |
| container_volume | 55 |
| creator | Otani, Tomohiro Ii, Satoshi Shigematsu, Tomoyoshi Fujinaka, Toshiyuki Hirata, Masayuki Ozaki, Tomohiko Wada, Shigeo |
| description | Coil embolization of cerebral aneurysms with inhomogeneous coil distribution leads to an incomplete occlusion of the aneurysm. However, the effects of this factor on the blood flow characteristics are still not fully understood. This study investigates the effects of coil configuration on the blood flow characteristics in a coil-embolized aneurysm using computational fluid dynamics (CFD) simulation. The blood flow analysis in the aneurysm with coil embolization was performed using a coil deployment (CD) model, in which the coil configuration was constructed using a physics-based simulation of the CD. In the CFD results, total flow momentum and kinetic energy in the aneurysm gradually decayed with increasing coil packing density (PD), regardless of the coil configuration attributed to deployment conditions. However, the total shear rate in the aneurysm was relatively high and the strength of the local shear flow varied based on the differences in coil configuration, even at adequate PDs used in clinical practice (20–25 %). Because the sufficient shear rate reduction is a well-known factor in the blood clot formation occluding the aneurysm inside, the present study gives useful insight into the effects of coil configuration on the treatment efficiency of coil embolization. |
| doi_str_mv | 10.1007/s11517-016-1541-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1826732357</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1899817705</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-5eae16b7937dbcef235c6b2f6b9265d3abd72c25735607401d111fca1654d0843</originalsourceid><addsrcrecordid>eNp1kUuLFTEQhYMoznX0B7iRgBs3ral0Ht1LufiCATe6DnlUZjJ0d65JN3L1z5s7dxQRhJAU1HdOFTmEPAf2GhjTbyqABN0xUB1IAZ16QHagW8GEEA_JjoFgrQvDBXlS6y1jHCQXj8kF1w3g47AjP_d5PmyrXVNe7ETruoUjjbnQ9QYpxoh-rTRH6nOa2rXEdL2VO5q246acA41T_k79jS3Wr1hSXZOvNC13mg5nl6f0AwP1WNCVNsQuuJVjnZ-SR9FOFZ_dv5fk6_t3X_Yfu6vPHz7t3151XvTD2km0CMrpsdfBeYy8l145HpUbuZKhty5o7rnUvVRMCwYBAKK3oKQIbBD9JXl19j2U_G3Dupo5VY_T1BbJWzUwcKX7Zqsb-vIf9DZvpf3MiRrHAbRmslFwpnzJtRaM5lDSbMvRADOnZMw5GdOSMadkjGqaF_fOm5sx_FH8jqIB_AzU1lqusfw1-r-uvwCuI5pH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1899817705</pqid></control><display><type>article</type><title>Computational study for the effects of coil configuration on blood flow characteristics in coil-embolized cerebral aneurysm</title><source>MEDLINE</source><source>Business Source Complete</source><source>Springer Nature - Complete Springer Journals</source><creator>Otani, Tomohiro ; Ii, Satoshi ; Shigematsu, Tomoyoshi ; Fujinaka, Toshiyuki ; Hirata, Masayuki ; Ozaki, Tomohiko ; Wada, Shigeo</creator><creatorcontrib>Otani, Tomohiro ; Ii, Satoshi ; Shigematsu, Tomoyoshi ; Fujinaka, Toshiyuki ; Hirata, Masayuki ; Ozaki, Tomohiko ; Wada, Shigeo</creatorcontrib><description>Coil embolization of cerebral aneurysms with inhomogeneous coil distribution leads to an incomplete occlusion of the aneurysm. However, the effects of this factor on the blood flow characteristics are still not fully understood. This study investigates the effects of coil configuration on the blood flow characteristics in a coil-embolized aneurysm using computational fluid dynamics (CFD) simulation. The blood flow analysis in the aneurysm with coil embolization was performed using a coil deployment (CD) model, in which the coil configuration was constructed using a physics-based simulation of the CD. In the CFD results, total flow momentum and kinetic energy in the aneurysm gradually decayed with increasing coil packing density (PD), regardless of the coil configuration attributed to deployment conditions. However, the total shear rate in the aneurysm was relatively high and the strength of the local shear flow varied based on the differences in coil configuration, even at adequate PDs used in clinical practice (20–25 %). Because the sufficient shear rate reduction is a well-known factor in the blood clot formation occluding the aneurysm inside, the present study gives useful insight into the effects of coil configuration on the treatment efficiency of coil embolization.</description><identifier>ISSN: 0140-0118</identifier><identifier>EISSN: 1741-0444</identifier><identifier>DOI: 10.1007/s11517-016-1541-6</identifier><identifier>PMID: 27444298</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aneurysm ; Aneurysms ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Blood coagulation ; Blood flow ; Cerebral blood flow ; Cerebrovascular Circulation - physiology ; Computational fluid dynamics ; Computer Applications ; Computer Simulation ; Configuration management ; Embolization ; Embolization, Therapeutic - methods ; Flow characteristics ; Hemodynamics - physiology ; Human Physiology ; Humans ; Hydrodynamics ; Imaging ; Intracranial Aneurysm - physiopathology ; Ischemia ; Kinetic energy ; Models, Cardiovascular ; Occlusion ; Original Article ; Packing density ; Radiology ; Shear flow ; Shear rate ; Stents</subject><ispartof>Medical & biological engineering & computing, 2017-05, Vol.55 (5), p.697-710</ispartof><rights>International Federation for Medical and Biological Engineering 2016</rights><rights>Medical & Biological Engineering & Computing is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-5eae16b7937dbcef235c6b2f6b9265d3abd72c25735607401d111fca1654d0843</citedby><cites>FETCH-LOGICAL-c438t-5eae16b7937dbcef235c6b2f6b9265d3abd72c25735607401d111fca1654d0843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11517-016-1541-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11517-016-1541-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27444298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Otani, Tomohiro</creatorcontrib><creatorcontrib>Ii, Satoshi</creatorcontrib><creatorcontrib>Shigematsu, Tomoyoshi</creatorcontrib><creatorcontrib>Fujinaka, Toshiyuki</creatorcontrib><creatorcontrib>Hirata, Masayuki</creatorcontrib><creatorcontrib>Ozaki, Tomohiko</creatorcontrib><creatorcontrib>Wada, Shigeo</creatorcontrib><title>Computational study for the effects of coil configuration on blood flow characteristics in coil-embolized cerebral aneurysm</title><title>Medical & biological engineering & computing</title><addtitle>Med Biol Eng Comput</addtitle><addtitle>Med Biol Eng Comput</addtitle><description>Coil embolization of cerebral aneurysms with inhomogeneous coil distribution leads to an incomplete occlusion of the aneurysm. However, the effects of this factor on the blood flow characteristics are still not fully understood. This study investigates the effects of coil configuration on the blood flow characteristics in a coil-embolized aneurysm using computational fluid dynamics (CFD) simulation. The blood flow analysis in the aneurysm with coil embolization was performed using a coil deployment (CD) model, in which the coil configuration was constructed using a physics-based simulation of the CD. In the CFD results, total flow momentum and kinetic energy in the aneurysm gradually decayed with increasing coil packing density (PD), regardless of the coil configuration attributed to deployment conditions. However, the total shear rate in the aneurysm was relatively high and the strength of the local shear flow varied based on the differences in coil configuration, even at adequate PDs used in clinical practice (20–25 %). Because the sufficient shear rate reduction is a well-known factor in the blood clot formation occluding the aneurysm inside, the present study gives useful insight into the effects of coil configuration on the treatment efficiency of coil embolization.</description><subject>Aneurysm</subject><subject>Aneurysms</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Blood coagulation</subject><subject>Blood flow</subject><subject>Cerebral blood flow</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Computational fluid dynamics</subject><subject>Computer Applications</subject><subject>Computer Simulation</subject><subject>Configuration management</subject><subject>Embolization</subject><subject>Embolization, Therapeutic - methods</subject><subject>Flow characteristics</subject><subject>Hemodynamics - physiology</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Hydrodynamics</subject><subject>Imaging</subject><subject>Intracranial Aneurysm - physiopathology</subject><subject>Ischemia</subject><subject>Kinetic energy</subject><subject>Models, Cardiovascular</subject><subject>Occlusion</subject><subject>Original Article</subject><subject>Packing density</subject><subject>Radiology</subject><subject>Shear flow</subject><subject>Shear rate</subject><subject>Stents</subject><issn>0140-0118</issn><issn>1741-0444</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUuLFTEQhYMoznX0B7iRgBs3ral0Ht1LufiCATe6DnlUZjJ0d65JN3L1z5s7dxQRhJAU1HdOFTmEPAf2GhjTbyqABN0xUB1IAZ16QHagW8GEEA_JjoFgrQvDBXlS6y1jHCQXj8kF1w3g47AjP_d5PmyrXVNe7ETruoUjjbnQ9QYpxoh-rTRH6nOa2rXEdL2VO5q246acA41T_k79jS3Wr1hSXZOvNC13mg5nl6f0AwP1WNCVNsQuuJVjnZ-SR9FOFZ_dv5fk6_t3X_Yfu6vPHz7t3151XvTD2km0CMrpsdfBeYy8l145HpUbuZKhty5o7rnUvVRMCwYBAKK3oKQIbBD9JXl19j2U_G3Dupo5VY_T1BbJWzUwcKX7Zqsb-vIf9DZvpf3MiRrHAbRmslFwpnzJtRaM5lDSbMvRADOnZMw5GdOSMadkjGqaF_fOm5sx_FH8jqIB_AzU1lqusfw1-r-uvwCuI5pH</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Otani, Tomohiro</creator><creator>Ii, Satoshi</creator><creator>Shigematsu, Tomoyoshi</creator><creator>Fujinaka, Toshiyuki</creator><creator>Hirata, Masayuki</creator><creator>Ozaki, Tomohiko</creator><creator>Wada, Shigeo</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7SC</scope><scope>7TB</scope><scope>7TS</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AL</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>JQ2</scope><scope>K60</scope><scope>K6~</scope><scope>K7-</scope><scope>K9.</scope><scope>KB0</scope><scope>L.-</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0C</scope><scope>M0N</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170501</creationdate><title>Computational study for the effects of coil configuration on blood flow characteristics in coil-embolized cerebral aneurysm</title><author>Otani, Tomohiro ; Ii, Satoshi ; Shigematsu, Tomoyoshi ; Fujinaka, Toshiyuki ; Hirata, Masayuki ; Ozaki, Tomohiko ; Wada, Shigeo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-5eae16b7937dbcef235c6b2f6b9265d3abd72c25735607401d111fca1654d0843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aneurysm</topic><topic>Aneurysms</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biomedicine</topic><topic>Blood coagulation</topic><topic>Blood flow</topic><topic>Cerebral blood flow</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Computational fluid dynamics</topic><topic>Computer Applications</topic><topic>Computer Simulation</topic><topic>Configuration management</topic><topic>Embolization</topic><topic>Embolization, Therapeutic - methods</topic><topic>Flow characteristics</topic><topic>Hemodynamics - physiology</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Hydrodynamics</topic><topic>Imaging</topic><topic>Intracranial Aneurysm - physiopathology</topic><topic>Ischemia</topic><topic>Kinetic energy</topic><topic>Models, Cardiovascular</topic><topic>Occlusion</topic><topic>Original Article</topic><topic>Packing density</topic><topic>Radiology</topic><topic>Shear flow</topic><topic>Shear rate</topic><topic>Stents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Otani, Tomohiro</creatorcontrib><creatorcontrib>Ii, Satoshi</creatorcontrib><creatorcontrib>Shigematsu, Tomoyoshi</creatorcontrib><creatorcontrib>Fujinaka, Toshiyuki</creatorcontrib><creatorcontrib>Hirata, Masayuki</creatorcontrib><creatorcontrib>Ozaki, Tomohiko</creatorcontrib><creatorcontrib>Wada, Shigeo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Computer and Information Systems Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Physical Education Index</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Computing Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>Computer Science Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>ABI/INFORM Global</collection><collection>Computing Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Medical & biological engineering & computing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Otani, Tomohiro</au><au>Ii, Satoshi</au><au>Shigematsu, Tomoyoshi</au><au>Fujinaka, Toshiyuki</au><au>Hirata, Masayuki</au><au>Ozaki, Tomohiko</au><au>Wada, Shigeo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Computational study for the effects of coil configuration on blood flow characteristics in coil-embolized cerebral aneurysm</atitle><jtitle>Medical & biological engineering & computing</jtitle><stitle>Med Biol Eng Comput</stitle><addtitle>Med Biol Eng Comput</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>55</volume><issue>5</issue><spage>697</spage><epage>710</epage><pages>697-710</pages><issn>0140-0118</issn><eissn>1741-0444</eissn><abstract>Coil embolization of cerebral aneurysms with inhomogeneous coil distribution leads to an incomplete occlusion of the aneurysm. However, the effects of this factor on the blood flow characteristics are still not fully understood. This study investigates the effects of coil configuration on the blood flow characteristics in a coil-embolized aneurysm using computational fluid dynamics (CFD) simulation. The blood flow analysis in the aneurysm with coil embolization was performed using a coil deployment (CD) model, in which the coil configuration was constructed using a physics-based simulation of the CD. In the CFD results, total flow momentum and kinetic energy in the aneurysm gradually decayed with increasing coil packing density (PD), regardless of the coil configuration attributed to deployment conditions. However, the total shear rate in the aneurysm was relatively high and the strength of the local shear flow varied based on the differences in coil configuration, even at adequate PDs used in clinical practice (20–25 %). Because the sufficient shear rate reduction is a well-known factor in the blood clot formation occluding the aneurysm inside, the present study gives useful insight into the effects of coil configuration on the treatment efficiency of coil embolization.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27444298</pmid><doi>10.1007/s11517-016-1541-6</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0140-0118 |
| ispartof | Medical & biological engineering & computing, 2017-05, Vol.55 (5), p.697-710 |
| issn | 0140-0118 1741-0444 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1826732357 |
| source | MEDLINE; Business Source Complete; Springer Nature - Complete Springer Journals |
| subjects | Aneurysm Aneurysms Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Blood coagulation Blood flow Cerebral blood flow Cerebrovascular Circulation - physiology Computational fluid dynamics Computer Applications Computer Simulation Configuration management Embolization Embolization, Therapeutic - methods Flow characteristics Hemodynamics - physiology Human Physiology Humans Hydrodynamics Imaging Intracranial Aneurysm - physiopathology Ischemia Kinetic energy Models, Cardiovascular Occlusion Original Article Packing density Radiology Shear flow Shear rate Stents |
| title | Computational study for the effects of coil configuration on blood flow characteristics in coil-embolized cerebral aneurysm |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T17%3A52%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Computational%20study%20for%20the%20effects%20of%20coil%20configuration%20on%20blood%20flow%20characteristics%20in%20coil-embolized%20cerebral%20aneurysm&rft.jtitle=Medical%20&%20biological%20engineering%20&%20computing&rft.au=Otani,%20Tomohiro&rft.date=2017-05-01&rft.volume=55&rft.issue=5&rft.spage=697&rft.epage=710&rft.pages=697-710&rft.issn=0140-0118&rft.eissn=1741-0444&rft_id=info:doi/10.1007/s11517-016-1541-6&rft_dat=%3Cproquest_cross%3E1899817705%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1899817705&rft_id=info:pmid/27444298&rfr_iscdi=true |