Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness
Abstract Introduction The Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers. Methods Among 672 cognitively normal participants (mean age, 79.8 years, 52.5% men), we investigated associati...
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| Veröffentlicht in: | Alzheimer's & dementia 2017-02, Vol.13 (2), p.168-177 |
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| creator | Staubo, Sara C Aakre, Jeremiah A Vemuri, Prashanthi Syrjanen, Jeremy A Mielke, Michelle M Geda, Yonas E Kremers, Walter K Machulda, Mary M Knopman, David S Petersen, Ronald C Jack, Clifford R Roberts, Rosebud O |
| description | Abstract Introduction The Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers. Methods Among 672 cognitively normal participants (mean age, 79.8 years, 52.5% men), we investigated associations of MeDi score and MeDi components with magnetic resonance imaging measures of cortical thickness for the four lobes separately and averaged (average lobar). Results Higher MeDi score was associated with larger frontal, parietal, occipital, and average lobar cortical thickness. Higher legume and fish intakes were associated with larger cortical thickness: legumes with larger superior parietal, inferior parietal, precuneus, parietal, occipital, lingual, and fish with larger precuneus, superior parietal, posterior cingulate, parietal, and inferior parietal. Higher carbohydrate and sugar intakes were associated with lower entorhinal cortical thickness. Discussion In this sample of elderly persons, higher adherence to MeDi was associated with larger cortical thickness. These cross-sectional findings require validation in prospective studies. |
| doi_str_mv | 10.1016/j.jalz.2016.06.2359 |
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Methods Among 672 cognitively normal participants (mean age, 79.8 years, 52.5% men), we investigated associations of MeDi score and MeDi components with magnetic resonance imaging measures of cortical thickness for the four lobes separately and averaged (average lobar). Results Higher MeDi score was associated with larger frontal, parietal, occipital, and average lobar cortical thickness. Higher legume and fish intakes were associated with larger cortical thickness: legumes with larger superior parietal, inferior parietal, precuneus, parietal, occipital, lingual, and fish with larger precuneus, superior parietal, posterior cingulate, parietal, and inferior parietal. Higher carbohydrate and sugar intakes were associated with lower entorhinal cortical thickness. Discussion In this sample of elderly persons, higher adherence to MeDi was associated with larger cortical thickness. These cross-sectional findings require validation in prospective studies.</description><identifier>ISSN: 1552-5260</identifier><identifier>EISSN: 1552-5279</identifier><identifier>DOI: 10.1016/j.jalz.2016.06.2359</identifier><identifier>PMID: 27461490</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Biomarkers ; Cerebral Cortex - diagnostic imaging ; Cortical thickness ; Cross-Sectional Studies ; Diet ; Diet, Mediterranean ; Female ; Fish ; Fruit ; Humans ; Legumes ; Macronutrients ; Magnetic Resonance Imaging ; Male ; Micronutrients ; Neurology ; Nutrition ; Organ Size ; Structural brain changes ; Sugar ; Vitamins</subject><ispartof>Alzheimer's & dementia, 2017-02, Vol.13 (2), p.168-177</ispartof><rights>the Alzheimer's Association</rights><rights>2016 the Alzheimer's Association</rights><rights>2017 The Alzheimer's Association</rights><rights>Copyright © 2016 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5199-6cec3ff5b35ac2fa5ece1768e2db996ac2ff99d8d3a20b6020ec0b1c05c767883</citedby><cites>FETCH-LOGICAL-c5199-6cec3ff5b35ac2fa5ece1768e2db996ac2ff99d8d3a20b6020ec0b1c05c767883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.jalz.2016.06.2359$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.jalz.2016.06.2359$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27461490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Staubo, Sara C</creatorcontrib><creatorcontrib>Aakre, Jeremiah A</creatorcontrib><creatorcontrib>Vemuri, Prashanthi</creatorcontrib><creatorcontrib>Syrjanen, Jeremy A</creatorcontrib><creatorcontrib>Mielke, Michelle M</creatorcontrib><creatorcontrib>Geda, Yonas E</creatorcontrib><creatorcontrib>Kremers, Walter K</creatorcontrib><creatorcontrib>Machulda, Mary M</creatorcontrib><creatorcontrib>Knopman, David S</creatorcontrib><creatorcontrib>Petersen, Ronald C</creatorcontrib><creatorcontrib>Jack, Clifford R</creatorcontrib><creatorcontrib>Roberts, Rosebud O</creatorcontrib><title>Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness</title><title>Alzheimer's & dementia</title><addtitle>Alzheimers Dement</addtitle><description>Abstract Introduction The Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers. Methods Among 672 cognitively normal participants (mean age, 79.8 years, 52.5% men), we investigated associations of MeDi score and MeDi components with magnetic resonance imaging measures of cortical thickness for the four lobes separately and averaged (average lobar). Results Higher MeDi score was associated with larger frontal, parietal, occipital, and average lobar cortical thickness. Higher legume and fish intakes were associated with larger cortical thickness: legumes with larger superior parietal, inferior parietal, precuneus, parietal, occipital, lingual, and fish with larger precuneus, superior parietal, posterior cingulate, parietal, and inferior parietal. Higher carbohydrate and sugar intakes were associated with lower entorhinal cortical thickness. Discussion In this sample of elderly persons, higher adherence to MeDi was associated with larger cortical thickness. These cross-sectional findings require validation in prospective studies.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Cortical thickness</subject><subject>Cross-Sectional Studies</subject><subject>Diet</subject><subject>Diet, Mediterranean</subject><subject>Female</subject><subject>Fish</subject><subject>Fruit</subject><subject>Humans</subject><subject>Legumes</subject><subject>Macronutrients</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Micronutrients</subject><subject>Neurology</subject><subject>Nutrition</subject><subject>Organ Size</subject><subject>Structural brain changes</subject><subject>Sugar</subject><subject>Vitamins</subject><issn>1552-5260</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhq2Kqi2FX4CEcuTQDf5YO_EBpGoF_dBWSNBekJDlTCbCaT6KnYC2v742u60QF7jY1qt3ZjzPDCGvGM0ZZeptm7e2u895fOdU5VxIvUeOmJR8IXmhnz29FT0kz0NoKV3SkskDcsiLpWJLTY_Ityus3YTe2wHtkNUOp5Osd-DHYZ68w2EKmR3qrLd_Sie_tavPF1mPNsweQzY2GYx-cmC7bPru4HbAEF6Q_cZ2AV_u7mNy8_HD9ep8sf50drE6XS9AMq0XChBE08hKSAu8sRIBWaFK5HWltUpao3Vd1sJyWinKKQKtGFAJhSrKUhyTN9u8d378MWOYTO8CYNfFrsY5GFZyVQhWlipaxdYa-wnBY2PuvOut3xhGTeJqWpO4msTVUGUS1xj1eldgrnqsn2IeQUbDamv45Trc_E9Oc7r-enkZjyRStSvzbpsFI6yfDr0JEIFDnJFHmEw9un988_1f8dC5Ic3kFjcY2nH2Q5yDYSZwQ82XtCBpP5gSXCmmxQNRUbRv</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Staubo, Sara C</creator><creator>Aakre, Jeremiah A</creator><creator>Vemuri, Prashanthi</creator><creator>Syrjanen, Jeremy A</creator><creator>Mielke, Michelle M</creator><creator>Geda, Yonas E</creator><creator>Kremers, Walter K</creator><creator>Machulda, Mary M</creator><creator>Knopman, David S</creator><creator>Petersen, Ronald C</creator><creator>Jack, Clifford R</creator><creator>Roberts, Rosebud O</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201702</creationdate><title>Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness</title><author>Staubo, Sara C ; Aakre, Jeremiah A ; Vemuri, Prashanthi ; Syrjanen, Jeremy A ; Mielke, Michelle M ; Geda, Yonas E ; Kremers, Walter K ; Machulda, Mary M ; Knopman, David S ; Petersen, Ronald C ; Jack, Clifford R ; Roberts, Rosebud O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5199-6cec3ff5b35ac2fa5ece1768e2db996ac2ff99d8d3a20b6020ec0b1c05c767883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers</topic><topic>Cerebral Cortex - diagnostic imaging</topic><topic>Cortical thickness</topic><topic>Cross-Sectional Studies</topic><topic>Diet</topic><topic>Diet, Mediterranean</topic><topic>Female</topic><topic>Fish</topic><topic>Fruit</topic><topic>Humans</topic><topic>Legumes</topic><topic>Macronutrients</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Micronutrients</topic><topic>Neurology</topic><topic>Nutrition</topic><topic>Organ Size</topic><topic>Structural brain changes</topic><topic>Sugar</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Staubo, Sara C</creatorcontrib><creatorcontrib>Aakre, Jeremiah A</creatorcontrib><creatorcontrib>Vemuri, Prashanthi</creatorcontrib><creatorcontrib>Syrjanen, Jeremy A</creatorcontrib><creatorcontrib>Mielke, Michelle M</creatorcontrib><creatorcontrib>Geda, Yonas E</creatorcontrib><creatorcontrib>Kremers, Walter K</creatorcontrib><creatorcontrib>Machulda, Mary M</creatorcontrib><creatorcontrib>Knopman, David S</creatorcontrib><creatorcontrib>Petersen, Ronald C</creatorcontrib><creatorcontrib>Jack, Clifford R</creatorcontrib><creatorcontrib>Roberts, Rosebud O</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alzheimer's & dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Staubo, Sara C</au><au>Aakre, Jeremiah A</au><au>Vemuri, Prashanthi</au><au>Syrjanen, Jeremy A</au><au>Mielke, Michelle M</au><au>Geda, Yonas E</au><au>Kremers, Walter K</au><au>Machulda, Mary M</au><au>Knopman, David S</au><au>Petersen, Ronald C</au><au>Jack, Clifford R</au><au>Roberts, Rosebud O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness</atitle><jtitle>Alzheimer's & dementia</jtitle><addtitle>Alzheimers Dement</addtitle><date>2017-02</date><risdate>2017</risdate><volume>13</volume><issue>2</issue><spage>168</spage><epage>177</epage><pages>168-177</pages><issn>1552-5260</issn><eissn>1552-5279</eissn><abstract>Abstract Introduction The Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers. Methods Among 672 cognitively normal participants (mean age, 79.8 years, 52.5% men), we investigated associations of MeDi score and MeDi components with magnetic resonance imaging measures of cortical thickness for the four lobes separately and averaged (average lobar). Results Higher MeDi score was associated with larger frontal, parietal, occipital, and average lobar cortical thickness. Higher legume and fish intakes were associated with larger cortical thickness: legumes with larger superior parietal, inferior parietal, precuneus, parietal, occipital, lingual, and fish with larger precuneus, superior parietal, posterior cingulate, parietal, and inferior parietal. Higher carbohydrate and sugar intakes were associated with lower entorhinal cortical thickness. Discussion In this sample of elderly persons, higher adherence to MeDi was associated with larger cortical thickness. 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| subjects | Aged Aged, 80 and over Biomarkers Cerebral Cortex - diagnostic imaging Cortical thickness Cross-Sectional Studies Diet Diet, Mediterranean Female Fish Fruit Humans Legumes Macronutrients Magnetic Resonance Imaging Male Micronutrients Neurology Nutrition Organ Size Structural brain changes Sugar Vitamins |
| title | Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness |
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