The Extracellular to Intracellular Water Ratio in Upper Legs is Negatively Associated With Skeletal Muscle Strength and Gait Speed in Older People
Skeletal muscles contain a large volume of water that is classified into intracellular (ICW) and extracellular (ECW) water fractions. Nuclear magnetic resonance-based biomarkers suggest that increased water T2 heterogeneities, as well as elevated water T2 relaxation in the quadriceps occurs in the e...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2017-03, Vol.72 (3), p.293-298 |
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| creator | Yamada, Yosuke Yoshida, Tsukasa Yokoyama, Keiichi Watanabe, Yuya Miyake, Motoko Yamagata, Emi Yamada, Minoru Kimura, Misaka |
| description | Skeletal muscles contain a large volume of water that is classified into intracellular (ICW) and extracellular (ECW) water fractions. Nuclear magnetic resonance-based biomarkers suggest that increased water T2 heterogeneities, as well as elevated water T2 relaxation in the quadriceps occurs in the elderly when compared with young adults. However, nuclear magnetic resonance is difficult to apply to a large-scale study or a clinical setting for sarcopenia and frailty screening. Segmental bioelectrical impedance spectroscopy is a unique tool used to assess the segmental ratio of ECW/ICW in the limbs. We evaluated 405 community-living people aged between 65 and 90 years. ECW and ICW in the upper legs were assessed by segmental bioelectrical impedance spectroscopy. Isometric knee extension strength, gait speed, and skeletal muscle mass were measured. Thigh ECW/ICW was negatively correlated with knee extension strength and gait speed (r = -.617 and -.431, respectively, p < .001) and increased with age (p < .001). Thigh ECW/ICW was a significant predictor of knee extension strength and gait speed independent of age, sex, body mass index, and skeletal muscle mass. Relative expansion of ECW against ICW in the thigh muscles is a factor in decreased muscle quality and a biomarker of muscle aging. |
| doi_str_mv | 10.1093/gerona/glw125 |
| format | Article |
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Nuclear magnetic resonance-based biomarkers suggest that increased water T2 heterogeneities, as well as elevated water T2 relaxation in the quadriceps occurs in the elderly when compared with young adults. However, nuclear magnetic resonance is difficult to apply to a large-scale study or a clinical setting for sarcopenia and frailty screening. Segmental bioelectrical impedance spectroscopy is a unique tool used to assess the segmental ratio of ECW/ICW in the limbs. We evaluated 405 community-living people aged between 65 and 90 years. ECW and ICW in the upper legs were assessed by segmental bioelectrical impedance spectroscopy. Isometric knee extension strength, gait speed, and skeletal muscle mass were measured. Thigh ECW/ICW was negatively correlated with knee extension strength and gait speed (r = -.617 and -.431, respectively, p < .001) and increased with age (p < .001). Thigh ECW/ICW was a significant predictor of knee extension strength and gait speed independent of age, sex, body mass index, and skeletal muscle mass. Relative expansion of ECW against ICW in the thigh muscles is a factor in decreased muscle quality and a biomarker of muscle aging.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glw125</identifier><identifier>PMID: 27422438</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Aged ; Aged, 80 and over ; Body Water ; Extracellular Fluid ; Female ; Gerontology ; Humans ; Intracellular Fluid ; Male ; Muscle Strength ; Muscle, Skeletal - physiology ; Musculoskeletal system ; Older people ; Thigh ; Velocity ; Walking ; Walking Speed ; Water</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2017-03, Vol.72 (3), p.293-298</ispartof><rights>The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>Copyright Oxford University Press, UK Mar 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-609242e6ae7eb88248095c7a99a5ccc22db5961e0a9399653ece77de182b9b5b3</citedby><cites>FETCH-LOGICAL-c360t-609242e6ae7eb88248095c7a99a5ccc22db5961e0a9399653ece77de182b9b5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27422438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamada, Yosuke</creatorcontrib><creatorcontrib>Yoshida, Tsukasa</creatorcontrib><creatorcontrib>Yokoyama, Keiichi</creatorcontrib><creatorcontrib>Watanabe, Yuya</creatorcontrib><creatorcontrib>Miyake, Motoko</creatorcontrib><creatorcontrib>Yamagata, Emi</creatorcontrib><creatorcontrib>Yamada, Minoru</creatorcontrib><creatorcontrib>Kimura, Misaka</creatorcontrib><creatorcontrib>Kyoto-Kameoka Study</creatorcontrib><creatorcontrib>Kyoto-Kameoka Study</creatorcontrib><title>The Extracellular to Intracellular Water Ratio in Upper Legs is Negatively Associated With Skeletal Muscle Strength and Gait Speed in Older People</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Skeletal muscles contain a large volume of water that is classified into intracellular (ICW) and extracellular (ECW) water fractions. Nuclear magnetic resonance-based biomarkers suggest that increased water T2 heterogeneities, as well as elevated water T2 relaxation in the quadriceps occurs in the elderly when compared with young adults. However, nuclear magnetic resonance is difficult to apply to a large-scale study or a clinical setting for sarcopenia and frailty screening. Segmental bioelectrical impedance spectroscopy is a unique tool used to assess the segmental ratio of ECW/ICW in the limbs. We evaluated 405 community-living people aged between 65 and 90 years. ECW and ICW in the upper legs were assessed by segmental bioelectrical impedance spectroscopy. Isometric knee extension strength, gait speed, and skeletal muscle mass were measured. Thigh ECW/ICW was negatively correlated with knee extension strength and gait speed (r = -.617 and -.431, respectively, p < .001) and increased with age (p < .001). Thigh ECW/ICW was a significant predictor of knee extension strength and gait speed independent of age, sex, body mass index, and skeletal muscle mass. Relative expansion of ECW against ICW in the thigh muscles is a factor in decreased muscle quality and a biomarker of muscle aging.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Body Water</subject><subject>Extracellular Fluid</subject><subject>Female</subject><subject>Gerontology</subject><subject>Humans</subject><subject>Intracellular Fluid</subject><subject>Male</subject><subject>Muscle Strength</subject><subject>Muscle, Skeletal - physiology</subject><subject>Musculoskeletal system</subject><subject>Older people</subject><subject>Thigh</subject><subject>Velocity</subject><subject>Walking</subject><subject>Walking Speed</subject><subject>Water</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtPxCAQx4nR-D56NSRevFQpLFCOxvhK1kdcjd4aSsdaZUsF6uNr-Ills2qMc5lh5pd_mPkjtJWTvZwott-Ad53eb-xbTvkCWs0lLzLO-P1iqolUGSdErKC1EJ7ILDhdRitUjigdsWIVfd48Aj56j14bsHaw2uPo8Fn3t3GnI3h8rWPrcNvh275PzzE0AbcBX0CTBq9gP_BBCM60Ca7xXRsf8eQZLERt8fkQjAU8iR66Jg10V-MT3UY86SHBSfPS1knzClxvYQMtPWgbYPM7r6Pb46Obw9NsfHlydngwzgwTJGaCKDqiIDRIqIqCjgqiuJFaKc2NMZTWFVciB6IVU0pwBgakrCEvaKUqXrF1tDvX7b17GSDEctqG2dK6AzeEMoFCsnRVkdCdf-iTG3yXfpcoSfJCUKoSlc0p410IHh7K3rdT7T_KnJQzs8q5WeXcrMRvf6sO1RTqX_rHHfYFaDySzQ</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Yamada, Yosuke</creator><creator>Yoshida, Tsukasa</creator><creator>Yokoyama, Keiichi</creator><creator>Watanabe, Yuya</creator><creator>Miyake, Motoko</creator><creator>Yamagata, Emi</creator><creator>Yamada, Minoru</creator><creator>Kimura, Misaka</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20170301</creationdate><title>The Extracellular to Intracellular Water Ratio in Upper Legs is Negatively Associated With Skeletal Muscle Strength and Gait Speed in Older People</title><author>Yamada, Yosuke ; Yoshida, Tsukasa ; Yokoyama, Keiichi ; Watanabe, Yuya ; Miyake, Motoko ; Yamagata, Emi ; Yamada, Minoru ; Kimura, Misaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-609242e6ae7eb88248095c7a99a5ccc22db5961e0a9399653ece77de182b9b5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Body Water</topic><topic>Extracellular Fluid</topic><topic>Female</topic><topic>Gerontology</topic><topic>Humans</topic><topic>Intracellular Fluid</topic><topic>Male</topic><topic>Muscle Strength</topic><topic>Muscle, Skeletal - physiology</topic><topic>Musculoskeletal system</topic><topic>Older people</topic><topic>Thigh</topic><topic>Velocity</topic><topic>Walking</topic><topic>Walking Speed</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamada, Yosuke</creatorcontrib><creatorcontrib>Yoshida, Tsukasa</creatorcontrib><creatorcontrib>Yokoyama, Keiichi</creatorcontrib><creatorcontrib>Watanabe, Yuya</creatorcontrib><creatorcontrib>Miyake, Motoko</creatorcontrib><creatorcontrib>Yamagata, Emi</creatorcontrib><creatorcontrib>Yamada, Minoru</creatorcontrib><creatorcontrib>Kimura, Misaka</creatorcontrib><creatorcontrib>Kyoto-Kameoka Study</creatorcontrib><creatorcontrib>Kyoto-Kameoka Study</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The journals of gerontology. 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| subjects | Aged Aged, 80 and over Body Water Extracellular Fluid Female Gerontology Humans Intracellular Fluid Male Muscle Strength Muscle, Skeletal - physiology Musculoskeletal system Older people Thigh Velocity Walking Walking Speed Water |
| title | The Extracellular to Intracellular Water Ratio in Upper Legs is Negatively Associated With Skeletal Muscle Strength and Gait Speed in Older People |
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