Differences between older and young patients with autoimmune gastritis
Aim Elderly patients with autoimmune gastritis might have different symptoms than those of young patients. The aim of the present study was to compare presented symptoms and laboratory parameters associated with autoimmune gastritis in both old and young age groups. Methods A total of 355 patients w...
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| Veröffentlicht in: | Geriatrics & gerontology international 2017-07, Vol.17 (7), p.1090-1095 |
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| container_title | Geriatrics & gerontology international |
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| creator | Kalkan, Çağdaş Soykan, Irfan |
| description | Aim
Elderly patients with autoimmune gastritis might have different symptoms than those of young patients. The aim of the present study was to compare presented symptoms and laboratory parameters associated with autoimmune gastritis in both old and young age groups.
Methods
A total of 355 patients with autoimmune gastritis were stratified into two groups: 65 years or older (n = 119, mean age 69.47 ± 5.027 years), and under 65 years (n = 236, mean age 45.79 ± 10.51 years). These two groups were then evaluated and compared by means of clinical symptoms, concurrent autoimmune diseases, serum gastrin, vitamin B12 and chromogranin A levels, and the presence of enterochromograffin‐like cell hyperplasia.
Results
Among 119 older patients, 35 had dyspeptic symptoms, and 84 patients were referred for vitamin B12 and/or iron deficiency. In the younger group (n = 236), there were more patients who had dyspeptic symptoms (36 vs 200, P |
| doi_str_mv | 10.1111/ggi.12832 |
| format | Article |
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Elderly patients with autoimmune gastritis might have different symptoms than those of young patients. The aim of the present study was to compare presented symptoms and laboratory parameters associated with autoimmune gastritis in both old and young age groups.
Methods
A total of 355 patients with autoimmune gastritis were stratified into two groups: 65 years or older (n = 119, mean age 69.47 ± 5.027 years), and under 65 years (n = 236, mean age 45.79 ± 10.51 years). These two groups were then evaluated and compared by means of clinical symptoms, concurrent autoimmune diseases, serum gastrin, vitamin B12 and chromogranin A levels, and the presence of enterochromograffin‐like cell hyperplasia.
Results
Among 119 older patients, 35 had dyspeptic symptoms, and 84 patients were referred for vitamin B12 and/or iron deficiency. In the younger group (n = 236), there were more patients who had dyspeptic symptoms (36 vs 200, P < 0.001). Serum gastrin (726.68 ± 266.183 vs 214.36 ± 104.62 pg/mL, P < 0.001) and chromogranin A (301.26 ± 172.95 vs 106.59 ± 67.66 ng/mL, P < 0.001) levels were significantly higher, and the presence of enterochromograffin‐like cell hyperplasia was more frequent (113 vs 31, P < 0.001) in older patients than younger patients. Polyautoimmunity (66.3% vs 24.5%) and multiple autoimmune syndrome (17.6% vs 5.5%) were more common in older patients (P < 0.001).
Conclusions
There are differences in the clinical characteristics and the laboratory parameters between patients with autoimmune gastritis that are older and younger than 65 years‐of‐age. Elderly patients with autoimmune gastritis were investigated more commonly for vitamin B12 and/or iron deficiency. Polyautoimmunity and multiple autoimmune syndrome were more common, and serum gastrin and chromogranin A levels were significantly higher in older patients. Geriatr Gerontol Int 2017; 17: 1090–1095.</description><identifier>ISSN: 1444-1586</identifier><identifier>EISSN: 1447-0594</identifier><identifier>DOI: 10.1111/ggi.12832</identifier><identifier>PMID: 27444719</identifier><language>eng</language><publisher>Japan: Blackwell Publishing Ltd</publisher><subject>Adult ; Age ; Age Distribution ; Aged ; Analysis of Variance ; Autoimmune diseases ; Autoimmune Diseases - diagnosis ; Autoimmune Diseases - epidemiology ; autoimmune gastritis ; Cohort Studies ; Female ; gastric emptying ; gastrin ; Gastrins - blood ; Gastritis - diagnosis ; Gastritis - epidemiology ; Gastritis - immunology ; Gastrointestinal diseases ; Geriatrics ; Humans ; Male ; Middle Aged ; multiple autoimmune syndrome ; Multivariate Analysis ; polyautoimmunity ; Prevalence ; Prognosis ; Retrospective Studies ; Risk Assessment ; Severity of Illness Index ; Statistics, Nonparametric ; Vitamin B 12 - blood</subject><ispartof>Geriatrics & gerontology international, 2017-07, Vol.17 (7), p.1090-1095</ispartof><rights>2016 Japan Geriatrics Society</rights><rights>2016 Japan Geriatrics Society.</rights><rights>2017 Japan Geriatrics Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3772-5e2e3ba07f35916ef5545d0cd34bf5cb45f6802b8a28c424f10af8de90fadfaf3</citedby><cites>FETCH-LOGICAL-c3772-5e2e3ba07f35916ef5545d0cd34bf5cb45f6802b8a28c424f10af8de90fadfaf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fggi.12832$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fggi.12832$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27444719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalkan, Çağdaş</creatorcontrib><creatorcontrib>Soykan, Irfan</creatorcontrib><title>Differences between older and young patients with autoimmune gastritis</title><title>Geriatrics & gerontology international</title><addtitle>Geriatr Gerontol Int</addtitle><description>Aim
Elderly patients with autoimmune gastritis might have different symptoms than those of young patients. The aim of the present study was to compare presented symptoms and laboratory parameters associated with autoimmune gastritis in both old and young age groups.
Methods
A total of 355 patients with autoimmune gastritis were stratified into two groups: 65 years or older (n = 119, mean age 69.47 ± 5.027 years), and under 65 years (n = 236, mean age 45.79 ± 10.51 years). These two groups were then evaluated and compared by means of clinical symptoms, concurrent autoimmune diseases, serum gastrin, vitamin B12 and chromogranin A levels, and the presence of enterochromograffin‐like cell hyperplasia.
Results
Among 119 older patients, 35 had dyspeptic symptoms, and 84 patients were referred for vitamin B12 and/or iron deficiency. In the younger group (n = 236), there were more patients who had dyspeptic symptoms (36 vs 200, P < 0.001). Serum gastrin (726.68 ± 266.183 vs 214.36 ± 104.62 pg/mL, P < 0.001) and chromogranin A (301.26 ± 172.95 vs 106.59 ± 67.66 ng/mL, P < 0.001) levels were significantly higher, and the presence of enterochromograffin‐like cell hyperplasia was more frequent (113 vs 31, P < 0.001) in older patients than younger patients. Polyautoimmunity (66.3% vs 24.5%) and multiple autoimmune syndrome (17.6% vs 5.5%) were more common in older patients (P < 0.001).
Conclusions
There are differences in the clinical characteristics and the laboratory parameters between patients with autoimmune gastritis that are older and younger than 65 years‐of‐age. Elderly patients with autoimmune gastritis were investigated more commonly for vitamin B12 and/or iron deficiency. Polyautoimmunity and multiple autoimmune syndrome were more common, and serum gastrin and chromogranin A levels were significantly higher in older patients. Geriatr Gerontol Int 2017; 17: 1090–1095.</description><subject>Adult</subject><subject>Age</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Autoimmune diseases</subject><subject>Autoimmune Diseases - diagnosis</subject><subject>Autoimmune Diseases - epidemiology</subject><subject>autoimmune gastritis</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>gastric emptying</subject><subject>gastrin</subject><subject>Gastrins - blood</subject><subject>Gastritis - diagnosis</subject><subject>Gastritis - epidemiology</subject><subject>Gastritis - immunology</subject><subject>Gastrointestinal diseases</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multiple autoimmune syndrome</subject><subject>Multivariate Analysis</subject><subject>polyautoimmunity</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Severity of Illness Index</subject><subject>Statistics, Nonparametric</subject><subject>Vitamin B 12 - blood</subject><issn>1444-1586</issn><issn>1447-0594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LwzAYgIMoTqcH_4AEvOihWz7b9CjTzcHAi55D2r6ZGf2YScvYv7eu04NgLm_gfXh4eRC6oWRC-zddr92EMsXZCbqgQiQRkak4PfxFRKWKR-gyhA0hNEkpPUcjlvSbhKYXaP7krAUPdQ4BZ9DuAGrclAV4bOoC75uuXuOtaR3UbcA7135g07WNq6quBrw2ofWudeEKnVlTBrg-zjF6nz-_zV6i1etiOXtcRTlPEhZJYMAzQxLLZUpjsFIKWZC84CKzMs-EtLEiLFOGqVwwYSkxVhWQEmsKaywfo_vBu_XNZweh1ZULOZSlqaHpgqaKxQmnlMQ9evcH3TSdr_vrNE0ZU5JxInvqYaBy34Tgweqtd5Xxe02J_o6r-7j6ELdnb4_GLqug-CV_avbAdAB2roT9_ya9WCwH5RcDboNR</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Kalkan, Çağdaş</creator><creator>Soykan, Irfan</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201707</creationdate><title>Differences between older and young patients with autoimmune gastritis</title><author>Kalkan, Çağdaş ; Soykan, Irfan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3772-5e2e3ba07f35916ef5545d0cd34bf5cb45f6802b8a28c424f10af8de90fadfaf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Autoimmune diseases</topic><topic>Autoimmune Diseases - diagnosis</topic><topic>Autoimmune Diseases - epidemiology</topic><topic>autoimmune gastritis</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>gastric emptying</topic><topic>gastrin</topic><topic>Gastrins - blood</topic><topic>Gastritis - diagnosis</topic><topic>Gastritis - epidemiology</topic><topic>Gastritis - immunology</topic><topic>Gastrointestinal diseases</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multiple autoimmune syndrome</topic><topic>Multivariate Analysis</topic><topic>polyautoimmunity</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Severity of Illness Index</topic><topic>Statistics, Nonparametric</topic><topic>Vitamin B 12 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalkan, Çağdaş</creatorcontrib><creatorcontrib>Soykan, Irfan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Geriatrics & gerontology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalkan, Çağdaş</au><au>Soykan, Irfan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences between older and young patients with autoimmune gastritis</atitle><jtitle>Geriatrics & gerontology international</jtitle><addtitle>Geriatr Gerontol Int</addtitle><date>2017-07</date><risdate>2017</risdate><volume>17</volume><issue>7</issue><spage>1090</spage><epage>1095</epage><pages>1090-1095</pages><issn>1444-1586</issn><eissn>1447-0594</eissn><abstract>Aim
Elderly patients with autoimmune gastritis might have different symptoms than those of young patients. The aim of the present study was to compare presented symptoms and laboratory parameters associated with autoimmune gastritis in both old and young age groups.
Methods
A total of 355 patients with autoimmune gastritis were stratified into two groups: 65 years or older (n = 119, mean age 69.47 ± 5.027 years), and under 65 years (n = 236, mean age 45.79 ± 10.51 years). These two groups were then evaluated and compared by means of clinical symptoms, concurrent autoimmune diseases, serum gastrin, vitamin B12 and chromogranin A levels, and the presence of enterochromograffin‐like cell hyperplasia.
Results
Among 119 older patients, 35 had dyspeptic symptoms, and 84 patients were referred for vitamin B12 and/or iron deficiency. In the younger group (n = 236), there were more patients who had dyspeptic symptoms (36 vs 200, P < 0.001). Serum gastrin (726.68 ± 266.183 vs 214.36 ± 104.62 pg/mL, P < 0.001) and chromogranin A (301.26 ± 172.95 vs 106.59 ± 67.66 ng/mL, P < 0.001) levels were significantly higher, and the presence of enterochromograffin‐like cell hyperplasia was more frequent (113 vs 31, P < 0.001) in older patients than younger patients. Polyautoimmunity (66.3% vs 24.5%) and multiple autoimmune syndrome (17.6% vs 5.5%) were more common in older patients (P < 0.001).
Conclusions
There are differences in the clinical characteristics and the laboratory parameters between patients with autoimmune gastritis that are older and younger than 65 years‐of‐age. Elderly patients with autoimmune gastritis were investigated more commonly for vitamin B12 and/or iron deficiency. Polyautoimmunity and multiple autoimmune syndrome were more common, and serum gastrin and chromogranin A levels were significantly higher in older patients. Geriatr Gerontol Int 2017; 17: 1090–1095.</abstract><cop>Japan</cop><pub>Blackwell Publishing Ltd</pub><pmid>27444719</pmid><doi>10.1111/ggi.12832</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Age Age Distribution Aged Analysis of Variance Autoimmune diseases Autoimmune Diseases - diagnosis Autoimmune Diseases - epidemiology autoimmune gastritis Cohort Studies Female gastric emptying gastrin Gastrins - blood Gastritis - diagnosis Gastritis - epidemiology Gastritis - immunology Gastrointestinal diseases Geriatrics Humans Male Middle Aged multiple autoimmune syndrome Multivariate Analysis polyautoimmunity Prevalence Prognosis Retrospective Studies Risk Assessment Severity of Illness Index Statistics, Nonparametric Vitamin B 12 - blood |
| title | Differences between older and young patients with autoimmune gastritis |
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