Multiple Periprosthetic Joint Infections: Evidence for Decreasing Prevalence

Abstract Background Multiple periprosthetic joint infections (MPJI) are uncommon. We determine the prevalence of developing a second-site periprosthetic joint infection. Methods Our institutional arthroplasty database was reviewed. Those who developed a second-site infection had a retrospective chart review to determine the pathogen, timing of infection, comorbidities and results of treatment. Results Thirteen of 206 (6.3%) patients at-risk for MPJI experienced a second periprosthetic joint infection. Mode of the second infection was hematogenous in six, all of whom were being treated for the index PJI. Seven secondary infections did not relate to the index infection. Two patients were lost to follow-up, five continued on suppressive antibiotics and six successfully cleared infection. Conclusion The prevalence of multiple PJI has decreased compared to previous reports.