Inhibition of endoplasmic reticulum stress and oxidative stress by vitamin D in endothelial cells

Endoplasmic reticulum (ER) stress and oxidative stress promote endothelial dysfunction and atherosclerosis. Since vitamin D has been shown in several studies to lower the risk of cardiovascular disease, we examined the effects of vitamin D on ER stress and oxidative stress in endothelial cells. ER s...

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Veröffentlicht in:	Free radical biology & medicine 2016-10, Vol.99, p.1-10
Hauptverfasser:	Haas, Michael J., Jafri, Mohammad, Wehmeier, Kent R., Onstead-Haas, Luisa M., Mooradian, Arshag D.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,25-dihydroxyvitamin D3 24,25-Dihydroxyvitamin D 3 - pharmacology Antioxidants - pharmacology Biomarkers - metabolism Calcitriol - analogs & derivatives Calcitriol - pharmacology Cardiovascular disease Cell Survival - drug effects Endoplasmic reticulum stress Endoplasmic Reticulum Stress - drug effects Endothelial cells Eukaryotic Initiation Factor-2 - genetics Eukaryotic Initiation Factor-2 - metabolism Gene Expression Glucose - antagonists & inhibitors Glucose - pharmacology Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans JNK Mitogen-Activated Protein Kinases - genetics JNK Mitogen-Activated Protein Kinases - metabolism Oxidative Stress - drug effects Phosphorylation Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism Tunicamycin - antagonists & inhibitors Tunicamycin - pharmacology Vitamin D - analogs & derivatives Vitamin D - pharmacology X-Box Binding Protein 1 - genetics X-Box Binding Protein 1 - metabolism
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