Impact of malignancy on Clostridium difficile infection
Purpose The purpose of this study was to investigate the impact of malignancy and chemotherapy on the clinical and microbiological characteristics of Clostridium difficile infections (CDI). Methods CDI patients with a history of malignancy within 5 years were defined as the cancer group. The charact...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2016-11, Vol.35 (11), p.1771-1776 |
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| container_title | European journal of clinical microbiology & infectious diseases |
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| creator | Chung, M. S. Kim, J. Kang, J. O. Pai, H. |
| description | Purpose
The purpose of this study was to investigate the impact of malignancy and chemotherapy on the clinical and microbiological characteristics of
Clostridium difficile
infections (CDI).
Methods
CDI patients with a history of malignancy within 5 years were defined as the cancer group. The characteristics of the patients were compared according to the presence of malignancy.
Results
Of 580 patients with CDI, 159 (27.4 %) belonged to the cancer group and 421 (72.6 %) to the non-cancer group. More of the patients in the cancer group than those in the non-cancer group had been hospitalized within the prior 2 months (
P
|
| doi_str_mv | 10.1007/s10096-016-2725-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1826730395</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1826730395</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-9cb9161d821e14c4d24f5923e22fee313973f98064f419a02f717823c0e289b53</originalsourceid><addsrcrecordid>eNp9kD1PwzAQhi0EoqXwA1hQRhaD7-za8YgqPipVYoHZSh27cpXExU4G_j2pUhhZ7oZ73le6h5BbYA_AmHrM49SSMpAUFS6pPCNzEHxJBVf8nMyZ5oJqhXxGrnLeszFTKnVJZqiEBESYE7VuD5Xti-iLtmrCrqs6-13Erlg1Mfcp1GFoizp4H2xoXBE672wfYndNLnzVZHdz2gvy-fL8sXqjm_fX9eppQy0XoqfabjVIqEsEB8KKGoVfauQO0TvHgWvFvS6ZFF6Arhh6BapEbpnDUm-XfEHup95Dil-Dy71pQ7auaarOxSEbKFEqzrg-ojChNsWck_PmkEJbpW8DzBx9mcmXGX2Zoy8jx8zdqX7Ytq7-S_wKGgGcgDyeup1LZh-H1I0v_9P6A80ec5s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1826730395</pqid></control><display><type>article</type><title>Impact of malignancy on Clostridium difficile infection</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Chung, M. S. ; Kim, J. ; Kang, J. O. ; Pai, H.</creator><creatorcontrib>Chung, M. S. ; Kim, J. ; Kang, J. O. ; Pai, H.</creatorcontrib><description>Purpose
The purpose of this study was to investigate the impact of malignancy and chemotherapy on the clinical and microbiological characteristics of
Clostridium difficile
infections (CDI).
Methods
CDI patients with a history of malignancy within 5 years were defined as the cancer group. The characteristics of the patients were compared according to the presence of malignancy.
Results
Of 580 patients with CDI, 159 (27.4 %) belonged to the cancer group and 421 (72.6 %) to the non-cancer group. More of the patients in the cancer group than those in the non-cancer group had been hospitalized within the prior 2 months (
P
< 0.001). Leukocytosis was more common in the non-cancer group (
P
= 0.034), while infection by PCR ribotype 017 strains was more common in the cancer group, with marginal significance (
P
= 0.07). Recurrence was more frequent in the cancer group (20.4 % vs. 9.5 %,
P
=0.005) and cancer was an independent risk factor for recurrence of CDI (OR = 2.66, 95 % CI 1.34-5.29,
P
=0.005). Age also contributed to the recurrence of CDI (OR = 1.03, 95 % CI 1.00-1.06,
P
=0.026).
Conclusions
Malignancy and age are independent risk factors for recurrence of CDI. Cancer patients require careful observation for recurrence after treatment of CDI.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-016-2725-6</identifier><identifier>PMID: 27461221</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Antineoplastic Agents - therapeutic use ; Biomedical and Life Sciences ; Biomedicine ; Clostridium difficile - isolation & purification ; Clostridium Infections - complications ; Clostridium Infections - epidemiology ; Clostridium Infections - microbiology ; Drug Therapy - methods ; Female ; Humans ; Internal Medicine ; Male ; Medical Microbiology ; Middle Aged ; Neoplasms - complications ; Neoplasms - drug therapy ; Original Article ; Recurrence ; Retrospective Studies</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2016-11, Vol.35 (11), p.1771-1776</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-9cb9161d821e14c4d24f5923e22fee313973f98064f419a02f717823c0e289b53</citedby><cites>FETCH-LOGICAL-c344t-9cb9161d821e14c4d24f5923e22fee313973f98064f419a02f717823c0e289b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-016-2725-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-016-2725-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27461221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, M. S.</creatorcontrib><creatorcontrib>Kim, J.</creatorcontrib><creatorcontrib>Kang, J. O.</creatorcontrib><creatorcontrib>Pai, H.</creatorcontrib><title>Impact of malignancy on Clostridium difficile infection</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Purpose
The purpose of this study was to investigate the impact of malignancy and chemotherapy on the clinical and microbiological characteristics of
Clostridium difficile
infections (CDI).
Methods
CDI patients with a history of malignancy within 5 years were defined as the cancer group. The characteristics of the patients were compared according to the presence of malignancy.
Results
Of 580 patients with CDI, 159 (27.4 %) belonged to the cancer group and 421 (72.6 %) to the non-cancer group. More of the patients in the cancer group than those in the non-cancer group had been hospitalized within the prior 2 months (
P
< 0.001). Leukocytosis was more common in the non-cancer group (
P
= 0.034), while infection by PCR ribotype 017 strains was more common in the cancer group, with marginal significance (
P
= 0.07). Recurrence was more frequent in the cancer group (20.4 % vs. 9.5 %,
P
=0.005) and cancer was an independent risk factor for recurrence of CDI (OR = 2.66, 95 % CI 1.34-5.29,
P
=0.005). Age also contributed to the recurrence of CDI (OR = 1.03, 95 % CI 1.00-1.06,
P
=0.026).
Conclusions
Malignancy and age are independent risk factors for recurrence of CDI. Cancer patients require careful observation for recurrence after treatment of CDI.</description><subject>Aged</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Clostridium difficile - isolation & purification</subject><subject>Clostridium Infections - complications</subject><subject>Clostridium Infections - epidemiology</subject><subject>Clostridium Infections - microbiology</subject><subject>Drug Therapy - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Middle Aged</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - drug therapy</subject><subject>Original Article</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwA1hQRhaD7-za8YgqPipVYoHZSh27cpXExU4G_j2pUhhZ7oZ73le6h5BbYA_AmHrM49SSMpAUFS6pPCNzEHxJBVf8nMyZ5oJqhXxGrnLeszFTKnVJZqiEBESYE7VuD5Xti-iLtmrCrqs6-13Erlg1Mfcp1GFoizp4H2xoXBE672wfYndNLnzVZHdz2gvy-fL8sXqjm_fX9eppQy0XoqfabjVIqEsEB8KKGoVfauQO0TvHgWvFvS6ZFF6Arhh6BapEbpnDUm-XfEHup95Dil-Dy71pQ7auaarOxSEbKFEqzrg-ojChNsWck_PmkEJbpW8DzBx9mcmXGX2Zoy8jx8zdqX7Ytq7-S_wKGgGcgDyeup1LZh-H1I0v_9P6A80ec5s</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Chung, M. S.</creator><creator>Kim, J.</creator><creator>Kang, J. O.</creator><creator>Pai, H.</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>Impact of malignancy on Clostridium difficile infection</title><author>Chung, M. S. ; Kim, J. ; Kang, J. O. ; Pai, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-9cb9161d821e14c4d24f5923e22fee313973f98064f419a02f717823c0e289b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Clostridium difficile - isolation & purification</topic><topic>Clostridium Infections - complications</topic><topic>Clostridium Infections - epidemiology</topic><topic>Clostridium Infections - microbiology</topic><topic>Drug Therapy - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Middle Aged</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - drug therapy</topic><topic>Original Article</topic><topic>Recurrence</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, M. S.</creatorcontrib><creatorcontrib>Kim, J.</creatorcontrib><creatorcontrib>Kang, J. O.</creatorcontrib><creatorcontrib>Pai, H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical microbiology & infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, M. S.</au><au>Kim, J.</au><au>Kang, J. O.</au><au>Pai, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of malignancy on Clostridium difficile infection</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>35</volume><issue>11</issue><spage>1771</spage><epage>1776</epage><pages>1771-1776</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>Purpose
The purpose of this study was to investigate the impact of malignancy and chemotherapy on the clinical and microbiological characteristics of
Clostridium difficile
infections (CDI).
Methods
CDI patients with a history of malignancy within 5 years were defined as the cancer group. The characteristics of the patients were compared according to the presence of malignancy.
Results
Of 580 patients with CDI, 159 (27.4 %) belonged to the cancer group and 421 (72.6 %) to the non-cancer group. More of the patients in the cancer group than those in the non-cancer group had been hospitalized within the prior 2 months (
P
< 0.001). Leukocytosis was more common in the non-cancer group (
P
= 0.034), while infection by PCR ribotype 017 strains was more common in the cancer group, with marginal significance (
P
= 0.07). Recurrence was more frequent in the cancer group (20.4 % vs. 9.5 %,
P
=0.005) and cancer was an independent risk factor for recurrence of CDI (OR = 2.66, 95 % CI 1.34-5.29,
P
=0.005). Age also contributed to the recurrence of CDI (OR = 1.03, 95 % CI 1.00-1.06,
P
=0.026).
Conclusions
Malignancy and age are independent risk factors for recurrence of CDI. Cancer patients require careful observation for recurrence after treatment of CDI.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27461221</pmid><doi>10.1007/s10096-016-2725-6</doi><tpages>6</tpages></addata></record> |
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| ispartof | European journal of clinical microbiology & infectious diseases, 2016-11, Vol.35 (11), p.1771-1776 |
| issn | 0934-9723 1435-4373 |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Aged Antineoplastic Agents - therapeutic use Biomedical and Life Sciences Biomedicine Clostridium difficile - isolation & purification Clostridium Infections - complications Clostridium Infections - epidemiology Clostridium Infections - microbiology Drug Therapy - methods Female Humans Internal Medicine Male Medical Microbiology Middle Aged Neoplasms - complications Neoplasms - drug therapy Original Article Recurrence Retrospective Studies |
| title | Impact of malignancy on Clostridium difficile infection |
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