Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II
In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, two polybrominated diphenyl ethers, 3,4,5-tribromo-2-(2′,4′-dibromophenoxy)-phenol ( 1 ) and 3,5-dibromo-2-(2′,4′-dibromophenoxy)-phenol ( 2 ) were isolated from an Indonesian marine spon...
Gespeichert in:
| Veröffentlicht in: | Journal of natural medicines 2017, Vol.71 (1), p.44-49 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 49 |
|---|---|
| container_issue | 1 |
| container_start_page | 44 |
| container_title | Journal of natural medicines |
| container_volume | 71 |
| creator | Arai, Masayoshi Shin, Dayoung Kamiya, Kentaro Ishida, Ryosuke Setiawan, Andi Kotoku, Naoyuki Kobayashi, Motomasa |
| description | In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, two polybrominated diphenyl ethers, 3,4,5-tribromo-2-(2′,4′-dibromophenoxy)-phenol (
1
) and 3,5-dibromo-2-(2′,4′-dibromophenoxy)-phenol (
2
) were isolated from an Indonesian marine sponge of
Dysidea
sp. Compounds
1
and
2
showed the anti-proliferative activity against PANC-1 cells under glucose-starved conditions with IC
50
values of 2.1 and 3.8 µM, respectively, whereas no growth inhibition was observed up to 30 µM in the general culture conditions. The further mechanistic analysis indicated that compound
1
might act mainly by inhibiting complex II in the mitochondrial electron transport chain. |
| doi_str_mv | 10.1007/s11418-016-1025-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1826729464</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1880806211</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-51ad9f207f2c95899c3d353a642a7204db567a0a33f1c30d6106e8f1ee57ca23</originalsourceid><addsrcrecordid>eNp1kcFu1DAQhiMEoqXwAFyQJS4cGvDYjpMcUUXLSkVceo9mncnGVWIH2ym7D8R74tW2CCFxmpHmm29s_UXxFvhH4Lz-FAEUNCUHXQIXVbl_VpxDo6HkopXPcy8VL6VS8qx4FeM950pICS-LM1Er1Uopzotf3zBYRywu3u0IHVv8dNgGP1uHiXrW22Ukd5gYpZFCvGSRJjLJPhDbBf8zjcy60W5t8iEy3KF1MbGMMoPOUGCGpikPelyOtuTZblqNj_lgwvCAyXp3-aSIbM4eM3rXB4sTM35eJtqzzeZ18WLAKdKbx3pR3F1_ubv6Wt5-v9lcfb4tjWx1KivAvh0Erwdh2qppWyN7WUnUSmAtuOq3la6Ro5QDGMl7DVxTMwBRVRsU8qL4cNIuwf9YKaZutvH4A3Tk19hBI3QtWqVVRt__g977Nbj8uEw1vOFaAGQKTpQJPsZAQ7cEO2M4dMC7Y4TdKcIuR9gdI-z2eefdo3ndztT_2XjKLAPiBMQ8yqGFv07_1_obVSyqtA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1880806211</pqid></control><display><type>article</type><title>Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Arai, Masayoshi ; Shin, Dayoung ; Kamiya, Kentaro ; Ishida, Ryosuke ; Setiawan, Andi ; Kotoku, Naoyuki ; Kobayashi, Motomasa</creator><creatorcontrib>Arai, Masayoshi ; Shin, Dayoung ; Kamiya, Kentaro ; Ishida, Ryosuke ; Setiawan, Andi ; Kotoku, Naoyuki ; Kobayashi, Motomasa</creatorcontrib><description>In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, two polybrominated diphenyl ethers, 3,4,5-tribromo-2-(2′,4′-dibromophenoxy)-phenol (
1
) and 3,5-dibromo-2-(2′,4′-dibromophenoxy)-phenol (
2
) were isolated from an Indonesian marine sponge of
Dysidea
sp. Compounds
1
and
2
showed the anti-proliferative activity against PANC-1 cells under glucose-starved conditions with IC
50
values of 2.1 and 3.8 µM, respectively, whereas no growth inhibition was observed up to 30 µM in the general culture conditions. The further mechanistic analysis indicated that compound
1
might act mainly by inhibiting complex II in the mitochondrial electron transport chain.</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-016-1025-x</identifier><identifier>PMID: 27449332</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Cancer therapies ; Complementary & Alternative Medicine ; Electron Transport Chain Complex Proteins ; Glucose ; Growth Inhibitors - metabolism ; Halogenated Diphenyl Ethers - pharmacology ; Marine biology ; Medicinal Chemistry ; Mitochondria ; Neoplasms - therapy ; Original Paper ; Pharmacology/Toxicology ; Pharmacy ; Phenols ; Phytochemicals ; Plant Sciences ; Porifera - chemistry</subject><ispartof>Journal of natural medicines, 2017, Vol.71 (1), p.44-49</ispartof><rights>The Japanese Society of Pharmacognosy and Springer Japan 2016</rights><rights>Copyright Springer Science & Business Media 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-51ad9f207f2c95899c3d353a642a7204db567a0a33f1c30d6106e8f1ee57ca23</citedby><cites>FETCH-LOGICAL-c396t-51ad9f207f2c95899c3d353a642a7204db567a0a33f1c30d6106e8f1ee57ca23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11418-016-1025-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11418-016-1025-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27449332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arai, Masayoshi</creatorcontrib><creatorcontrib>Shin, Dayoung</creatorcontrib><creatorcontrib>Kamiya, Kentaro</creatorcontrib><creatorcontrib>Ishida, Ryosuke</creatorcontrib><creatorcontrib>Setiawan, Andi</creatorcontrib><creatorcontrib>Kotoku, Naoyuki</creatorcontrib><creatorcontrib>Kobayashi, Motomasa</creatorcontrib><title>Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, two polybrominated diphenyl ethers, 3,4,5-tribromo-2-(2′,4′-dibromophenoxy)-phenol (
1
) and 3,5-dibromo-2-(2′,4′-dibromophenoxy)-phenol (
2
) were isolated from an Indonesian marine sponge of
Dysidea
sp. Compounds
1
and
2
showed the anti-proliferative activity against PANC-1 cells under glucose-starved conditions with IC
50
values of 2.1 and 3.8 µM, respectively, whereas no growth inhibition was observed up to 30 µM in the general culture conditions. The further mechanistic analysis indicated that compound
1
might act mainly by inhibiting complex II in the mitochondrial electron transport chain.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer therapies</subject><subject>Complementary & Alternative Medicine</subject><subject>Electron Transport Chain Complex Proteins</subject><subject>Glucose</subject><subject>Growth Inhibitors - metabolism</subject><subject>Halogenated Diphenyl Ethers - pharmacology</subject><subject>Marine biology</subject><subject>Medicinal Chemistry</subject><subject>Mitochondria</subject><subject>Neoplasms - therapy</subject><subject>Original Paper</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Phenols</subject><subject>Phytochemicals</subject><subject>Plant Sciences</subject><subject>Porifera - chemistry</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFu1DAQhiMEoqXwAFyQJS4cGvDYjpMcUUXLSkVceo9mncnGVWIH2ym7D8R74tW2CCFxmpHmm29s_UXxFvhH4Lz-FAEUNCUHXQIXVbl_VpxDo6HkopXPcy8VL6VS8qx4FeM950pICS-LM1Er1Uopzotf3zBYRywu3u0IHVv8dNgGP1uHiXrW22Ukd5gYpZFCvGSRJjLJPhDbBf8zjcy60W5t8iEy3KF1MbGMMoPOUGCGpikPelyOtuTZblqNj_lgwvCAyXp3-aSIbM4eM3rXB4sTM35eJtqzzeZ18WLAKdKbx3pR3F1_ubv6Wt5-v9lcfb4tjWx1KivAvh0Erwdh2qppWyN7WUnUSmAtuOq3la6Ro5QDGMl7DVxTMwBRVRsU8qL4cNIuwf9YKaZutvH4A3Tk19hBI3QtWqVVRt__g977Nbj8uEw1vOFaAGQKTpQJPsZAQ7cEO2M4dMC7Y4TdKcIuR9gdI-z2eefdo3ndztT_2XjKLAPiBMQ8yqGFv07_1_obVSyqtA</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Arai, Masayoshi</creator><creator>Shin, Dayoung</creator><creator>Kamiya, Kentaro</creator><creator>Ishida, Ryosuke</creator><creator>Setiawan, Andi</creator><creator>Kotoku, Naoyuki</creator><creator>Kobayashi, Motomasa</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>2017</creationdate><title>Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II</title><author>Arai, Masayoshi ; Shin, Dayoung ; Kamiya, Kentaro ; Ishida, Ryosuke ; Setiawan, Andi ; Kotoku, Naoyuki ; Kobayashi, Motomasa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-51ad9f207f2c95899c3d353a642a7204db567a0a33f1c30d6106e8f1ee57ca23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer therapies</topic><topic>Complementary & Alternative Medicine</topic><topic>Electron Transport Chain Complex Proteins</topic><topic>Glucose</topic><topic>Growth Inhibitors - metabolism</topic><topic>Halogenated Diphenyl Ethers - pharmacology</topic><topic>Marine biology</topic><topic>Medicinal Chemistry</topic><topic>Mitochondria</topic><topic>Neoplasms - therapy</topic><topic>Original Paper</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Phenols</topic><topic>Phytochemicals</topic><topic>Plant Sciences</topic><topic>Porifera - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arai, Masayoshi</creatorcontrib><creatorcontrib>Shin, Dayoung</creatorcontrib><creatorcontrib>Kamiya, Kentaro</creatorcontrib><creatorcontrib>Ishida, Ryosuke</creatorcontrib><creatorcontrib>Setiawan, Andi</creatorcontrib><creatorcontrib>Kotoku, Naoyuki</creatorcontrib><creatorcontrib>Kobayashi, Motomasa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arai, Masayoshi</au><au>Shin, Dayoung</au><au>Kamiya, Kentaro</au><au>Ishida, Ryosuke</au><au>Setiawan, Andi</au><au>Kotoku, Naoyuki</au><au>Kobayashi, Motomasa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2017</date><risdate>2017</risdate><volume>71</volume><issue>1</issue><spage>44</spage><epage>49</epage><pages>44-49</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, two polybrominated diphenyl ethers, 3,4,5-tribromo-2-(2′,4′-dibromophenoxy)-phenol (
1
) and 3,5-dibromo-2-(2′,4′-dibromophenoxy)-phenol (
2
) were isolated from an Indonesian marine sponge of
Dysidea
sp. Compounds
1
and
2
showed the anti-proliferative activity against PANC-1 cells under glucose-starved conditions with IC
50
values of 2.1 and 3.8 µM, respectively, whereas no growth inhibition was observed up to 30 µM in the general culture conditions. The further mechanistic analysis indicated that compound
1
might act mainly by inhibiting complex II in the mitochondrial electron transport chain.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>27449332</pmid><doi>10.1007/s11418-016-1025-x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1340-3443 |
| ispartof | Journal of natural medicines, 2017, Vol.71 (1), p.44-49 |
| issn | 1340-3443 1861-0293 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1826729464 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Biomedical and Life Sciences Biomedicine Cancer therapies Complementary & Alternative Medicine Electron Transport Chain Complex Proteins Glucose Growth Inhibitors - metabolism Halogenated Diphenyl Ethers - pharmacology Marine biology Medicinal Chemistry Mitochondria Neoplasms - therapy Original Paper Pharmacology/Toxicology Pharmacy Phenols Phytochemicals Plant Sciences Porifera - chemistry |
| title | Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T17%3A51%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Marine%20spongean%20polybrominated%20diphenyl%20ethers,%20selective%20growth%20inhibitors%20against%20the%20cancer%20cells%20adapted%20to%20glucose%20starvation,%20inhibits%20mitochondrial%20complex%20II&rft.jtitle=Journal%20of%20natural%20medicines&rft.au=Arai,%20Masayoshi&rft.date=2017&rft.volume=71&rft.issue=1&rft.spage=44&rft.epage=49&rft.pages=44-49&rft.issn=1340-3443&rft.eissn=1861-0293&rft_id=info:doi/10.1007/s11418-016-1025-x&rft_dat=%3Cproquest_cross%3E1880806211%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1880806211&rft_id=info:pmid/27449332&rfr_iscdi=true |