Continuing efforts to standardize measured serum growth hormone values in Japan
Determination of serum growth hormone (GH) levels is mandatory for diagnosis of GH deficiency and excess. In the present study, we, the Study Committee for GH and Its Related Factors, The Foundation for Growth Science, Japan measured GH values in serum samples using all the commercially available ki...
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| Veröffentlicht in: | ENDOCRINE JOURNAL 2016, Vol.63(10), pp.933-936 |
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| container_title | ENDOCRINE JOURNAL |
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| creator | Katsumata, Noriyuki Shimatsu, Akira Tachibana, Katsuhiko Hizuka, Naomi Horikawa, Reiko Yokoya, Susumu Tatsumi, Ke-ita Mochizuki, Takahiro Anzo, Makoto Tanaka, Toshiaki |
| description | Determination of serum growth hormone (GH) levels is mandatory for diagnosis of GH deficiency and excess. In the present study, we, the Study Committee for GH and Its Related Factors, The Foundation for Growth Science, Japan measured GH values in serum samples using all the commercially available kits in Japan. Significant discrepancies in the GH values were observed among the kits in spite of using the unified recombinant human GH-based standards. To deal with the discrepancies, we established a formula using a linear structural relationship model and were able to standardize the GH values. We propose to use the formula to diagnose GH deficiency and excess in Japan. |
| doi_str_mv | 10.1507/endocrj.EJ16-0198 |
| format | Article |
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In the present study, we, the Study Committee for GH and Its Related Factors, The Foundation for Growth Science, Japan measured GH values in serum samples using all the commercially available kits in Japan. Significant discrepancies in the GH values were observed among the kits in spite of using the unified recombinant human GH-based standards. To deal with the discrepancies, we established a formula using a linear structural relationship model and were able to standardize the GH values. We propose to use the formula to diagnose GH deficiency and excess in Japan.</description><subject>Adult</subject><subject>Assay kit</subject><subject>Diagnostic Techniques, Endocrine - standards</subject><subject>Growth Disorders - blood</subject><subject>Growth Disorders - diagnosis</subject><subject>Growth hormone (GH)</subject><subject>Human Growth Hormone - analysis</subject><subject>Human Growth Hormone - blood</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Japan</subject><subject>Reagent Kits, Diagnostic - standards</subject><subject>Reference Standards</subject><subject>Reference Values</subject><subject>Somatropin</subject><subject>WHO IS</subject><issn>0918-8959</issn><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1u3CAUhVHUqpkmfYBsKpbdOOXPYJbVKE0aRcqmWSOMLzMe2TABu1X69MWdqTcXJL57zuEgdEPJLa2J-gqhiy4dbu8eqawI1c0F2lAumkrUgrxDG6JpUzW61pfoY84HQjivBf-ALpkSNeOKb9DzNoapD3Mfdhi8j2nKeIo4TzZ0NnX9H8Aj2Dwn6HCGNI94l-LvaY_3MY0xAP5lhxky7gN-tEcbrtF7b4cMn87nFXr5fvdz-1A9Pd__2H57qpziYqqkt62XtPYN87QTIBRAw6gt1xq059wr3YjWCelab6VsgaiWcc2obKgqwBX6ctI9pvhaAkxm7LODYbAB4pwNbZhUTAtaF5SeUJdizgm8OaZ-tOnNUGKWHs25R7P0aJYey87ns_zcjtCtG_-LK8D9CSivvbNDDEMfwBzinEL5t3Gv8p-qYWTRJJIXM0K0IZrzZcgipYlarB5OSodS-g5WK5um3g2whpN8yVvmmnJF3N6mwvG_PNOhsQ</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Katsumata, Noriyuki</creator><creator>Shimatsu, Akira</creator><creator>Tachibana, Katsuhiko</creator><creator>Hizuka, Naomi</creator><creator>Horikawa, Reiko</creator><creator>Yokoya, Susumu</creator><creator>Tatsumi, Ke-ita</creator><creator>Mochizuki, Takahiro</creator><creator>Anzo, Makoto</creator><creator>Tanaka, Toshiaki</creator><general>The Japan Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2016</creationdate><title>Continuing efforts to standardize measured serum growth hormone values in Japan</title><author>Katsumata, Noriyuki ; 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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Assay kit Diagnostic Techniques, Endocrine - standards Growth Disorders - blood Growth Disorders - diagnosis Growth hormone (GH) Human Growth Hormone - analysis Human Growth Hormone - blood Humans Immunoassay Japan Reagent Kits, Diagnostic - standards Reference Standards Reference Values Somatropin WHO IS |
| title | Continuing efforts to standardize measured serum growth hormone values in Japan |
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