Nonoperative management of grade III blunt thoracic aortic injuries

Objective Blunt thoracic aortic injuries (BTAIs) have historically been treated with open surgery; thoracic endovascular aortic repair (TEVAR), however, is rapidly becoming the standard of care for all grades of injury. Previous studies have shown successful, conservative management of low-grade (I...

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Veröffentlicht in:Journal of vascular surgery 2016-12, Vol.64 (6), p.1580-1586
Hauptverfasser: Gandhi, Sagar S., MD, Blas, Joseph V., MD, Lee, Stewart, MS, Eidt, John F., MD, Carsten, Christopher G., MD
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container_end_page 1586
container_issue 6
container_start_page 1580
container_title Journal of vascular surgery
container_volume 64
creator Gandhi, Sagar S., MD
Blas, Joseph V., MD
Lee, Stewart, MS
Eidt, John F., MD
Carsten, Christopher G., MD
description Objective Blunt thoracic aortic injuries (BTAIs) have historically been treated with open surgery; thoracic endovascular aortic repair (TEVAR), however, is rapidly becoming the standard of care for all grades of injury. Previous studies have shown successful, conservative management of low-grade (I and II) BTAI, but limited literature exists regarding nonoperative management (NOM) for high-grade BTAI. The purpose of this study was to evaluate NOM for grade III BTAI compared with TEVAR. Methods There were 75 patients diagnosed with BTAI between January 2004 and June 2015. Of these, 40 were excluded for different grades of BTAI (17), death before any treatment (6), and need for urgent open repair (17). The remaining 35 patients were divided into two groups by treatment approach: NOM (n = 18) and TEVAR (n = 17). Primary end points were complications and mortality. The secondary end point was difference in pseudoaneurysm and aortic diameter measurements between groups. Results The groups of patients were similar in age, gender, Injury Severity Score, length of stay, in-hospital mortality, and hospital-associated complications. There were four TEVAR-related complications: graft involutions (2), type I endoleak (1), and distal embolization (1). All TEVAR-related complications required either an adjunctive procedure at the time of the primary procedure or an additional procedure. No patients from the NOM group required operative intervention. There were seven in-hospital mortalities: two in the TEVAR group (11.8%) and five in the NOM group (27.8%; P  = .402). One death in the NOM group was related to aortic disease. Follow-up computed tomography imaging revealed similar aortic-related outcomes between groups, with a high proportion showing resolved or improved aortic injury (NOM, 87.5%; TEVAR, 92.9%; P  = .674). Initial computed tomography imaging showed similar aortic diameters between groups. The average diameter of the aorta distal to the subclavian artery was 22.6 mm in the NOM group vs 22.8 mm in the TEVAR group ( P  = .85). The average maximum diameter of the pseudoaneurysm was 30.1 mm in the TEVAR group and 29.9 mm in the NOM group ( P  = .90). The average ratio of diameter of the pseudoaneurysm to diameter of the aorta distal to the subclavian artery was 1.32 for the TEVAR group and 1.33 for the NOM group ( P  = .85). Conclusions The natural history of grade III BTAIs is not well described. This study suggests that observation and NOM of grade III BTAI ma
doi_str_mv 10.1016/j.jvs.2016.05.070
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Previous studies have shown successful, conservative management of low-grade (I and II) BTAI, but limited literature exists regarding nonoperative management (NOM) for high-grade BTAI. The purpose of this study was to evaluate NOM for grade III BTAI compared with TEVAR. Methods There were 75 patients diagnosed with BTAI between January 2004 and June 2015. Of these, 40 were excluded for different grades of BTAI (17), death before any treatment (6), and need for urgent open repair (17). The remaining 35 patients were divided into two groups by treatment approach: NOM (n = 18) and TEVAR (n = 17). Primary end points were complications and mortality. The secondary end point was difference in pseudoaneurysm and aortic diameter measurements between groups. Results The groups of patients were similar in age, gender, Injury Severity Score, length of stay, in-hospital mortality, and hospital-associated complications. There were four TEVAR-related complications: graft involutions (2), type I endoleak (1), and distal embolization (1). All TEVAR-related complications required either an adjunctive procedure at the time of the primary procedure or an additional procedure. No patients from the NOM group required operative intervention. There were seven in-hospital mortalities: two in the TEVAR group (11.8%) and five in the NOM group (27.8%; P  = .402). One death in the NOM group was related to aortic disease. Follow-up computed tomography imaging revealed similar aortic-related outcomes between groups, with a high proportion showing resolved or improved aortic injury (NOM, 87.5%; TEVAR, 92.9%; P  = .674). Initial computed tomography imaging showed similar aortic diameters between groups. The average diameter of the aorta distal to the subclavian artery was 22.6 mm in the NOM group vs 22.8 mm in the TEVAR group ( P  = .85). The average maximum diameter of the pseudoaneurysm was 30.1 mm in the TEVAR group and 29.9 mm in the NOM group ( P  = .90). The average ratio of diameter of the pseudoaneurysm to diameter of the aorta distal to the subclavian artery was 1.32 for the TEVAR group and 1.33 for the NOM group ( P  = .85). Conclusions The natural history of grade III BTAIs is not well described. This study suggests that observation and NOM of grade III BTAI may be a reasonable therapeutic option in selected patients. It also speaks to the need for further delineation of the natural history of this injury. Serial imaging and long-term follow-up are necessary to monitor the progression of the pseudoaneurysm.</description><identifier>ISSN: 0741-5214</identifier><identifier>EISSN: 1097-6809</identifier><identifier>DOI: 10.1016/j.jvs.2016.05.070</identifier><identifier>PMID: 27461999</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Aneurysm, False - diagnostic imaging ; Aneurysm, False - mortality ; Aneurysm, False - surgery ; Aneurysm, False - therapy ; Aorta, Thoracic - diagnostic imaging ; Aorta, Thoracic - injuries ; Aorta, Thoracic - surgery ; Aortic Aneurysm, Thoracic - diagnostic imaging ; Aortic Aneurysm, Thoracic - mortality ; Aortic Aneurysm, Thoracic - surgery ; Aortic Aneurysm, Thoracic - therapy ; Aortography - methods ; Blood Vessel Prosthesis Implantation - adverse effects ; Blood Vessel Prosthesis Implantation - mortality ; Computed Tomography Angiography ; Databases, Factual ; Disease Progression ; Endovascular Procedures - adverse effects ; Endovascular Procedures - mortality ; Female ; Hospital Mortality ; Humans ; Injury Severity Score ; Length of Stay ; Male ; Middle Aged ; Postoperative Complications - etiology ; Postoperative Complications - mortality ; Retrospective Studies ; Risk Factors ; Surgery ; Thoracic Injuries - diagnostic imaging ; Thoracic Injuries - mortality ; Thoracic Injuries - surgery ; Thoracic Injuries - therapy ; Time Factors ; Treatment Outcome ; Vascular System Injuries - diagnostic imaging ; Vascular System Injuries - mortality ; Vascular System Injuries - surgery ; Vascular System Injuries - therapy ; Wounds, Nonpenetrating - diagnostic imaging ; Wounds, Nonpenetrating - mortality ; Wounds, Nonpenetrating - surgery ; Wounds, Nonpenetrating - therapy</subject><ispartof>Journal of vascular surgery, 2016-12, Vol.64 (6), p.1580-1586</ispartof><rights>Society for Vascular Surgery</rights><rights>2016 Society for Vascular Surgery</rights><rights>Copyright © 2016 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-d603f4045cdc18bcf24c178e0a54b1d85394504eccafbd135579717229b3141b3</citedby><cites>FETCH-LOGICAL-c451t-d603f4045cdc18bcf24c178e0a54b1d85394504eccafbd135579717229b3141b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0741521416304001$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27461999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gandhi, Sagar S., MD</creatorcontrib><creatorcontrib>Blas, Joseph V., MD</creatorcontrib><creatorcontrib>Lee, Stewart, MS</creatorcontrib><creatorcontrib>Eidt, John F., MD</creatorcontrib><creatorcontrib>Carsten, Christopher G., MD</creatorcontrib><title>Nonoperative management of grade III blunt thoracic aortic injuries</title><title>Journal of vascular surgery</title><addtitle>J Vasc Surg</addtitle><description>Objective Blunt thoracic aortic injuries (BTAIs) have historically been treated with open surgery; thoracic endovascular aortic repair (TEVAR), however, is rapidly becoming the standard of care for all grades of injury. Previous studies have shown successful, conservative management of low-grade (I and II) BTAI, but limited literature exists regarding nonoperative management (NOM) for high-grade BTAI. The purpose of this study was to evaluate NOM for grade III BTAI compared with TEVAR. Methods There were 75 patients diagnosed with BTAI between January 2004 and June 2015. Of these, 40 were excluded for different grades of BTAI (17), death before any treatment (6), and need for urgent open repair (17). The remaining 35 patients were divided into two groups by treatment approach: NOM (n = 18) and TEVAR (n = 17). Primary end points were complications and mortality. The secondary end point was difference in pseudoaneurysm and aortic diameter measurements between groups. Results The groups of patients were similar in age, gender, Injury Severity Score, length of stay, in-hospital mortality, and hospital-associated complications. There were four TEVAR-related complications: graft involutions (2), type I endoleak (1), and distal embolization (1). All TEVAR-related complications required either an adjunctive procedure at the time of the primary procedure or an additional procedure. No patients from the NOM group required operative intervention. There were seven in-hospital mortalities: two in the TEVAR group (11.8%) and five in the NOM group (27.8%; P  = .402). One death in the NOM group was related to aortic disease. Follow-up computed tomography imaging revealed similar aortic-related outcomes between groups, with a high proportion showing resolved or improved aortic injury (NOM, 87.5%; TEVAR, 92.9%; P  = .674). Initial computed tomography imaging showed similar aortic diameters between groups. The average diameter of the aorta distal to the subclavian artery was 22.6 mm in the NOM group vs 22.8 mm in the TEVAR group ( P  = .85). The average maximum diameter of the pseudoaneurysm was 30.1 mm in the TEVAR group and 29.9 mm in the NOM group ( P  = .90). The average ratio of diameter of the pseudoaneurysm to diameter of the aorta distal to the subclavian artery was 1.32 for the TEVAR group and 1.33 for the NOM group ( P  = .85). Conclusions The natural history of grade III BTAIs is not well described. This study suggests that observation and NOM of grade III BTAI may be a reasonable therapeutic option in selected patients. It also speaks to the need for further delineation of the natural history of this injury. Serial imaging and long-term follow-up are necessary to monitor the progression of the pseudoaneurysm.</description><subject>Adult</subject><subject>Aged</subject><subject>Aneurysm, False - diagnostic imaging</subject><subject>Aneurysm, False - mortality</subject><subject>Aneurysm, False - surgery</subject><subject>Aneurysm, False - therapy</subject><subject>Aorta, Thoracic - diagnostic imaging</subject><subject>Aorta, Thoracic - injuries</subject><subject>Aorta, Thoracic - surgery</subject><subject>Aortic Aneurysm, Thoracic - diagnostic imaging</subject><subject>Aortic Aneurysm, Thoracic - mortality</subject><subject>Aortic Aneurysm, Thoracic - surgery</subject><subject>Aortic Aneurysm, Thoracic - therapy</subject><subject>Aortography - methods</subject><subject>Blood Vessel Prosthesis Implantation - adverse effects</subject><subject>Blood Vessel Prosthesis Implantation - mortality</subject><subject>Computed Tomography Angiography</subject><subject>Databases, Factual</subject><subject>Disease Progression</subject><subject>Endovascular Procedures - adverse effects</subject><subject>Endovascular Procedures - mortality</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Injury Severity Score</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - mortality</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Thoracic Injuries - diagnostic imaging</subject><subject>Thoracic Injuries - mortality</subject><subject>Thoracic Injuries - surgery</subject><subject>Thoracic Injuries - therapy</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Vascular System Injuries - diagnostic imaging</subject><subject>Vascular System Injuries - mortality</subject><subject>Vascular System Injuries - surgery</subject><subject>Vascular System Injuries - therapy</subject><subject>Wounds, Nonpenetrating - diagnostic imaging</subject><subject>Wounds, Nonpenetrating - mortality</subject><subject>Wounds, Nonpenetrating - surgery</subject><subject>Wounds, Nonpenetrating - therapy</subject><issn>0741-5214</issn><issn>1097-6809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kTGP1DAQhS0E4paDH0CDUtIkzDh2HAsJCa0OWOkEBVBbjjM5HJJ4sZOV7t_j1R4UFFQzGr33pPkeYy8RKgRs3ozVeEoVz2sFsgIFj9gOQauyaUE_ZjtQAkvJUVyxZymNAIiyVU_ZFVeiQa31ju0_hyUcKdrVn6iY7WLvaKZlLcJQ3EXbU3E4HIpu2vJp_RGidd4VNsQ1D7-MW_SUnrMng50SvXiY1-z7h5tv-0_l7ZePh_3729IJiWvZN1APAoR0vcO2cwMXDlVLYKXosG9lrYUEQc7ZoeuxllJphYpz3dUosKuv2etL7jGGXxul1cw-OZomu1DYksGWN4or1JCleJG6GFKKNJhj9LON9wbBnNmZ0WR25szOgDSZXfa8eojfupn6v44_sLLg7UVA-cmTp2iS87Q46n0kt5o--P_Gv_vH7Sa_eGenn3RPaQxbXDI9gyZxA-brubxzd9jUIHJ19W_a7pMP</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Gandhi, Sagar S., MD</creator><creator>Blas, Joseph V., MD</creator><creator>Lee, Stewart, MS</creator><creator>Eidt, John F., MD</creator><creator>Carsten, Christopher G., MD</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161201</creationdate><title>Nonoperative management of grade III blunt thoracic aortic injuries</title><author>Gandhi, Sagar S., MD ; Blas, Joseph V., MD ; Lee, Stewart, MS ; Eidt, John F., MD ; Carsten, Christopher G., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-d603f4045cdc18bcf24c178e0a54b1d85394504eccafbd135579717229b3141b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aneurysm, False - diagnostic imaging</topic><topic>Aneurysm, False - mortality</topic><topic>Aneurysm, False - surgery</topic><topic>Aneurysm, False - therapy</topic><topic>Aorta, Thoracic - diagnostic imaging</topic><topic>Aorta, Thoracic - injuries</topic><topic>Aorta, Thoracic - surgery</topic><topic>Aortic Aneurysm, Thoracic - diagnostic imaging</topic><topic>Aortic Aneurysm, Thoracic - mortality</topic><topic>Aortic Aneurysm, Thoracic - surgery</topic><topic>Aortic Aneurysm, Thoracic - therapy</topic><topic>Aortography - methods</topic><topic>Blood Vessel Prosthesis Implantation - adverse effects</topic><topic>Blood Vessel Prosthesis Implantation - mortality</topic><topic>Computed Tomography Angiography</topic><topic>Databases, Factual</topic><topic>Disease Progression</topic><topic>Endovascular Procedures - adverse effects</topic><topic>Endovascular Procedures - mortality</topic><topic>Female</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Injury Severity Score</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - mortality</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Thoracic Injuries - diagnostic imaging</topic><topic>Thoracic Injuries - mortality</topic><topic>Thoracic Injuries - surgery</topic><topic>Thoracic Injuries - therapy</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Vascular System Injuries - diagnostic imaging</topic><topic>Vascular System Injuries - mortality</topic><topic>Vascular System Injuries - surgery</topic><topic>Vascular System Injuries - therapy</topic><topic>Wounds, Nonpenetrating - diagnostic imaging</topic><topic>Wounds, Nonpenetrating - mortality</topic><topic>Wounds, Nonpenetrating - surgery</topic><topic>Wounds, Nonpenetrating - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gandhi, Sagar S., MD</creatorcontrib><creatorcontrib>Blas, Joseph V., MD</creatorcontrib><creatorcontrib>Lee, Stewart, MS</creatorcontrib><creatorcontrib>Eidt, John F., MD</creatorcontrib><creatorcontrib>Carsten, Christopher G., MD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of vascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gandhi, Sagar S., MD</au><au>Blas, Joseph V., MD</au><au>Lee, Stewart, MS</au><au>Eidt, John F., MD</au><au>Carsten, Christopher G., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nonoperative management of grade III blunt thoracic aortic injuries</atitle><jtitle>Journal of vascular surgery</jtitle><addtitle>J Vasc Surg</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>64</volume><issue>6</issue><spage>1580</spage><epage>1586</epage><pages>1580-1586</pages><issn>0741-5214</issn><eissn>1097-6809</eissn><abstract>Objective Blunt thoracic aortic injuries (BTAIs) have historically been treated with open surgery; thoracic endovascular aortic repair (TEVAR), however, is rapidly becoming the standard of care for all grades of injury. Previous studies have shown successful, conservative management of low-grade (I and II) BTAI, but limited literature exists regarding nonoperative management (NOM) for high-grade BTAI. The purpose of this study was to evaluate NOM for grade III BTAI compared with TEVAR. Methods There were 75 patients diagnosed with BTAI between January 2004 and June 2015. Of these, 40 were excluded for different grades of BTAI (17), death before any treatment (6), and need for urgent open repair (17). The remaining 35 patients were divided into two groups by treatment approach: NOM (n = 18) and TEVAR (n = 17). Primary end points were complications and mortality. The secondary end point was difference in pseudoaneurysm and aortic diameter measurements between groups. Results The groups of patients were similar in age, gender, Injury Severity Score, length of stay, in-hospital mortality, and hospital-associated complications. There were four TEVAR-related complications: graft involutions (2), type I endoleak (1), and distal embolization (1). All TEVAR-related complications required either an adjunctive procedure at the time of the primary procedure or an additional procedure. No patients from the NOM group required operative intervention. There were seven in-hospital mortalities: two in the TEVAR group (11.8%) and five in the NOM group (27.8%; P  = .402). One death in the NOM group was related to aortic disease. Follow-up computed tomography imaging revealed similar aortic-related outcomes between groups, with a high proportion showing resolved or improved aortic injury (NOM, 87.5%; TEVAR, 92.9%; P  = .674). Initial computed tomography imaging showed similar aortic diameters between groups. The average diameter of the aorta distal to the subclavian artery was 22.6 mm in the NOM group vs 22.8 mm in the TEVAR group ( P  = .85). The average maximum diameter of the pseudoaneurysm was 30.1 mm in the TEVAR group and 29.9 mm in the NOM group ( P  = .90). The average ratio of diameter of the pseudoaneurysm to diameter of the aorta distal to the subclavian artery was 1.32 for the TEVAR group and 1.33 for the NOM group ( P  = .85). Conclusions The natural history of grade III BTAIs is not well described. This study suggests that observation and NOM of grade III BTAI may be a reasonable therapeutic option in selected patients. It also speaks to the need for further delineation of the natural history of this injury. Serial imaging and long-term follow-up are necessary to monitor the progression of the pseudoaneurysm.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27461999</pmid><doi>10.1016/j.jvs.2016.05.070</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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subjects Adult
Aged
Aneurysm, False - diagnostic imaging
Aneurysm, False - mortality
Aneurysm, False - surgery
Aneurysm, False - therapy
Aorta, Thoracic - diagnostic imaging
Aorta, Thoracic - injuries
Aorta, Thoracic - surgery
Aortic Aneurysm, Thoracic - diagnostic imaging
Aortic Aneurysm, Thoracic - mortality
Aortic Aneurysm, Thoracic - surgery
Aortic Aneurysm, Thoracic - therapy
Aortography - methods
Blood Vessel Prosthesis Implantation - adverse effects
Blood Vessel Prosthesis Implantation - mortality
Computed Tomography Angiography
Databases, Factual
Disease Progression
Endovascular Procedures - adverse effects
Endovascular Procedures - mortality
Female
Hospital Mortality
Humans
Injury Severity Score
Length of Stay
Male
Middle Aged
Postoperative Complications - etiology
Postoperative Complications - mortality
Retrospective Studies
Risk Factors
Surgery
Thoracic Injuries - diagnostic imaging
Thoracic Injuries - mortality
Thoracic Injuries - surgery
Thoracic Injuries - therapy
Time Factors
Treatment Outcome
Vascular System Injuries - diagnostic imaging
Vascular System Injuries - mortality
Vascular System Injuries - surgery
Vascular System Injuries - therapy
Wounds, Nonpenetrating - diagnostic imaging
Wounds, Nonpenetrating - mortality
Wounds, Nonpenetrating - surgery
Wounds, Nonpenetrating - therapy
title Nonoperative management of grade III blunt thoracic aortic injuries
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